Gene: Rdh10

Basic information

Tag Content
Uniprot ID Q8VCH7; Q8CJ68;
Entrez ID 98711
Genbank protein ID AAH19796.2; AAN64749.1;
Genbank nucleotide ID NM_133832.3
Ensembl protein ID ENSMUSP00000027053
Ensembl nucleotide ID ENSMUSG00000025921
Gene name Retinol dehydrogenase 10
Gene symbol Rdh10
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21930923
Functional description Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development.
Sequence
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR 60
ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGKG EEEILPPCNL QVFTYTCDVG 120
KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF 180
LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL 240
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMRAI LTDQPMVCTP RLMYIVTFMK 300
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I 341

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRDH10282852Q8HZT6Bos taurusPredictionMore>>
1:1 orthologRDH10486998E2R0Q8Canis lupus familiarisPredictionMore>>
1:1 orthologRDH10102180778A0A452EW84Capra hircusPredictionMore>>
1:1 orthologRDH10157506Q8IZV5Homo sapiensPredictionMore>>
1:1 orthologRdh1098711Q8VCH7CPOMus musculusPublicationMore>>
1:1 orthologRDH10472795H2QWA8Pan troglodytesPredictionMore>>
1:1 orthologRDH10A0A286ZUS8Sus scrofaPredictionMore>>
1:1 orthologRDH10100340133G1SV43Oryctolagus cuniculusPredictionMore>>
1:1 orthologRdh10353252Q80ZF7Rattus norvegicusPredictionMore>>
1:1 orthologrdh10aF1RES0Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004745 retinol dehydrogenase activityISO
GO:0004745 retinol dehydrogenase activityIMP
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorIBA
GO:0052650 NADP-retinol dehydrogenase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001656 metanephros developmentIMP
GO:0001701 in utero embryonic developmentIMP
GO:0002138 retinoic acid biosynthetic processIMP
GO:0007601 visual perceptionISO
GO:0008406 gonad developmentIMP
GO:0009887 animal organ morphogenesisIMP
GO:0014032 neural crest cell developmentIMP
GO:0031076 embryonic camera-type eye developmentIMP
GO:0035115 embryonic forelimb morphogenesisIMP
GO:0042572 retinol metabolic processIEA
GO:0042572 retinol metabolic processISO
GO:0042574 retinal metabolic processISO
GO:0043583 ear developmentIMP
GO:0043584 nose developmentIMP
GO:0048568 embryonic organ developmentIMP
GO:0048703 embryonic viscerocranium morphogenesisIMP
GO:0055114 oxidation-reduction processIEA
GO:0060431 primary lung bud formationIMP
GO:0060449 bud elongation involved in lung branchingIMP
GO:1900054 positive regulation of retinoic acid biosynthetic processISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005737 cytoplasmISO
GO:0005789 endoplasmic reticulum membraneIEA
GO:0005811 lipid dropletIBA
GO:0016020 membraneIDA
GO:0016021 integral component of membraneISO
GO:0043231 intracellular membrane-bounded organelleISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-2187338 Visual phototransductionIEA
R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)IEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-418594 G alpha (i) signalling eventsIEA
R-MMU-5362517 Signaling by Retinoic AcidIEA
R-MMU-5365859 RA biosynthesis pathwayIEA
R-MMU-9006931 Signaling by Nuclear ReceptorsIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0256 Endoplasmic reticulum
KW-0472 Membrane
KW-0492 Microsome
KW-0521 NADP
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR036291 NAD(P)-bd_dom_sf
IPR032970 RDH10
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

PROSITE

PROSITE ID PROSITE Term
PS00061 ADH_SHORT

Pfam

Pfam ID Pfam Term
PF00106 adh_short

Protein-miRNA interaction