Gene: Bag4

Basic information

Tag Content
Uniprot ID Q8CI61; Q3TRL9; Q91VT5; Q9CWG2;
Entrez ID 67384
Genbank protein ID AAL99586.1; AAH37239.1; BAB27167.1; AAH09102.1; BAE23161.1; AAH58518.1; BAE37009.1;
Genbank nucleotide ID NM_026121.3
Ensembl protein ID ENSMUSP00000044725
Ensembl nucleotide ID ENSMUSG00000037316
Gene name BAG family molecular chaperone regulator 4
Gene symbol Bag4
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity).
Sequence
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HVPPPLYPPL RPEPPQPPVS WRGRGGAPAE 60
TTWPGEGAGG DGYYPSGGAW AEASRAGGGH QEQPPYPGYN SNYWNSVRPR APYPGSYSVR 120
PELQGQSLNS YANGAYGPPY PPGPGASTAS YSGAYYVPGY TQSNYSTEVP NTYRSPGNSP 180
TPMSRWMYSQ QDCPTEAPPL RGQVPGYPAS QNPGMTLPHY PYGDGNRAVP QSGGTGRPQD 240
DAWASSAYGM GARYPWPSAA PSAPSAGSLY MTESASPWPG NSSPQPPPSP PPQQPKDPSY 300
SYNPSGQGLS RHSFPCSVHQ YESPGAVNND NSDLLDSQVQ YSAEPQLYGN ASSEHPSNQV 360
PSNNLPEECF SSDEGTPPSI KKIIHVLEKV QFLEQEVEEF VGKKTDKAYW LLEEMLTKEL 420
LELDSVETGG QDSVRQARKE AVCKIQAILE KLEKKGL 457

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBAG4516353F1MSS9Bos taurusPredictionMore>>
1:1 orthologBAG4607954E2R7V4Canis lupus familiarisPredictionMore>>
1:1 orthologBAG4102179734A0A452FDQ9Capra hircusPredictionMore>>
1:1 orthologBAG4100057730F6RTR6Equus caballusPredictionMore>>
1:1 orthologBAG49530O95429Homo sapiensPublicationMore>>
1:1 orthologBag467384Q8CI61Mus musculusPredictionMore>>
1:1 orthologBAG4H2QW14Pan troglodytesPredictionMore>>
1:1 orthologBAG4A0A287AP23Sus scrofaPredictionMore>>
1:1 orthologBAG4100353212G1T9D0Oryctolagus cuniculusPredictionMore>>
1:1 orthologBag4F1M3K6Rattus norvegicusPredictionMore>>
1:1 orthologbag4100001980B8JJ17Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
BAG4rs7836805Genotyping17366557

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0031625 ubiquitin protein ligase bindingISO
GO:0044877 protein-containing complex bindingISO
GO:0051087 chaperone bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0006915 apoptotic processRCA
GO:0010763 positive regulation of fibroblast migrationIMP
GO:0030838 positive regulation of actin filament polymerizationIMP
GO:0033138 positive regulation of peptidyl-serine phosphorylationIMP
GO:0042981 regulation of apoptotic processRCA
GO:0045785 positive regulation of cell adhesionIMP
GO:0051496 positive regulation of stress fiber assemblyIMP
GO:0051897 positive regulation of protein kinase B signalingIMP
GO:0071356 cellular response to tumor necrosis factorISO
GO:0071364 cellular response to epidermal growth factor stimulusIDA
GO:0072659 protein localization to plasma membraneIDA
GO:0090367 negative regulation of mRNA modificationISO
GO:0097178 ruffle assemblyIMP
GO:1903215 negative regulation of protein targeting to mitochondrionISO
GO:2001145 negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activityIDA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005737 cytoplasmISO
GO:0005829 cytosolISO
GO:0005886 plasma membraneISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-2262752 Cellular responses to stressIEA
R-MMU-3371453 Regulation of HSF1-mediated heat shock responseIEA
R-MMU-3371556 Cellular response to heat stressIEA
R-MMU-73887 Death Receptor SignallingIEA
R-MMU-75893 TNF signalingIEA
R-MMU-8953897 Cellular responses to external stimuliIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0143 Chaperone
KW-0963 Cytoplasm
KW-0488 Methylation
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain

PROSITE

PROSITE ID PROSITE Term
PS51035 BAG

Pfam

Pfam ID Pfam Term
PF02179 BAG

Protein-protein interaction

Protein-miRNA interaction