Gene: gdf11

Basic information

Tag Content
Uniprot ID Q8JFP9
Entrez ID 406247
Genbank protein ID AAN03678.2; AAI34029.1;
Genbank nucleotide ID NM_212975.1
Ensembl protein ID ENSDARP00000066032
Ensembl nucleotide ID ENSDARG00000044924
Gene name Gdf11-like
Gene symbol gdf11
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKRYNFLLCL TVLISLGLSG SDEPNLFLAP LSEMSSDIGV SLFDVDDVES SECSACVWRE 60
QSKVLRLETI KSQILSKLRL KQAPNISREV VNQLLPKAPP LQQLLDHHDF QGDASSLEDF 120
IDADEYHATT ESVITMASEP EPLVQVDGKP TCCFFKFSPK LMFTKVLKAQ LWVYLQPLKQ 180
TSTVYLQILR LKPITEQGSR HIRIRSLKIE LDSQAGHWQS IDFKHVLQNW FKQPHTNWGI 240
DINAYDESGN DLAVTSLGPG EEGLQPFLEV KILETTKRSR RNLGLDCDEH STESRCCRYP 300
LTVDFEAFGW DWIIAPKRYK ANYCSGQCEY MFMQKYPHTH LVQHANPRGS AGPCCTPTKM 360
SPINMLYFND KQQIIHGKIP GMVVDRCGCS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGDF11J9NYK9Canis lupus familiarisPredictionMore>>
1:1 orthologGDF11102178704A0A452DM24Capra hircusPredictionMore>>
1:1 orthologGDF1110220O95390Homo sapiensPredictionMore>>
1:1 orthologGdf1114561Q9Z1W4CPOMus musculusPublicationMore>>
1:1 orthologGDF11451970H2Q663Pan troglodytesPredictionMore>>
1:1 orthologGDF11F1SPJ6Sus scrofaPredictionMore>>
1:1 orthologGdf1129454Q9Z217Rattus norvegicusPredictionMore>>
1:1 orthologgdf11406247Q8JFP9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0009952 anterior/posterior pattern specification
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide