| Tag | Content |
|---|---|
| Uniprot ID | Q9Z1W4; Q9QX55; Q9R221; |
| Entrez ID | 14561 |
| Genbank protein ID | AAF21633.1; AAC72853.1; AAD05267.1; |
| Genbank nucleotide ID | NM_010272.2 |
| Ensembl protein ID | ENSMUSP00000026408 |
| Ensembl nucleotide ID | ENSMUSG00000025352 |
| Gene name | Growth/differentiation factor 11 |
| Gene symbol | Gdf11 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19298661; 24019467; 10391213; |
| Functional description | Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development (PubMed:10391213). May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:16845371, PubMed:12414726). |
| Sequence | MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAG VGGERSSRPA PSAPPEPDGC 60 PVCVWRQHSR ELRLESIKSQ ILSKLRLKEA PNISREVVKQ LLPKAPPLQQ ILDLHDFQGD 120 ALQPEDFLEE DEYHATTETV ISMAQETDPA VQTDGSPLCC HFHFSPKVMF TKVLKAQLWV 180 YLRPVPRPAT VYLQILRLKP LTGEGTAGGG GGGRRHIRIR SLKIELHSRS GHWQSIDFKQ 240 VLHSWFRQPQ SNWGIEINAF DPSGTDLAVT SLGPGAEGLH PFMELRVLEN TKRSRRNLGL 300 DCDEHSSESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GQCEYMFMQK YPHTHLVQQA 360 NPRGSAGPCC TPTKMSPINM LYFNDKQQII YGKIPGMVVD RCGCS 405 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GDF11 | J9NYK9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | GDF11 | 102178704 | A0A452DM24 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GDF11 | 10220 | O95390 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gdf11 | 14561 | Q9Z1W4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GDF11 | 451970 | H2Q663 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GDF11 | F1SPJ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Gdf11 | 29454 | Q9Z217 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gdf11 | 406247 | Q8JFP9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005125 | cytokine activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0008083 | growth factor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IGI |
| GO:0001656 | metanephros development | IDA |
| GO:0001657 | ureteric bud development | IMP |
| GO:0008285 | negative regulation of cell population proliferation | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA |
| GO:0021512 | spinal cord anterior/posterior patterning | IMP |
| GO:0031016 | pancreas development | IMP |
| GO:0045596 | negative regulation of cell differentiation | IDA |
| GO:0045665 | negative regulation of neuron differentiation | ISO |
| GO:0048469 | cell maturation | IMP |
| GO:0048593 | camera-type eye morphogenesis | IMP |
| GO:0060021 | roof of mouth development | IGI |
| GO:0060395 | SMAD protein signal transduction | ISS |
| GO:0060395 | SMAD protein signal transduction | ISO |
| GO:0060395 | SMAD protein signal transduction | IDA |
| GO:0060395 | SMAD protein signal transduction | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IDA |
| GO:0005615 | extracellular space | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|