Gene: Osr2

Basic information

Tag Content
Uniprot ID Q91ZD1; Q8BPV6; Q91V54;
Entrez ID 107587
Genbank protein ID AAK74068.1; BAC34859.1; AAH13504.1; AAL07364.1;
Genbank nucleotide ID XM_006520013.3; NM_054049.2;
Ensembl protein ID ENSMUSP00000154286; ENSMUSP00000022952;
Ensembl nucleotide ID ENSMUSG00000022330
Gene name Protein odd-skipped-related 2
Gene symbol Osr2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E12.5, E13.5, E14.5
Data sources Manually collected
Reference 15175245; 21420399;
Functional description
Sequence
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH MNHWTLGYPS 60
VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG AIAHVLPALH KDRPRFDFAN 120
LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLNPDRKPS RGRLPSKTKK EFICKFCGRH 180
FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS 240
RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 300
RHSLTHTPRQ NF 312

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologOSR2508692Q3T135Bos taurusPredictionMore>>
1:1 orthologOSR2481980E2QTV1Canis lupus familiarisPredictionMore>>
1:1 orthologOSR2102177997A0A452F9L8Capra hircusPredictionMore>>
1:1 orthologOSR2E5RH04Homo sapiensPredictionMore>>
1:1 orthologOsr2107587Q91ZD1CPOE12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologOSR2464306H2QWH9Pan troglodytesPredictionMore>>
1:1 orthologOSR2100155180F1S0N7Sus scrofaPredictionMore>>
1:1 orthologOsr2315039Q6AY34Rattus norvegicusPredictionMore>>
1:1 orthologosr2F1R0J1Danio rerioPredictionMore>>

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIBA
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIDA
GO:0043565 sequence-specific DNA bindingIDA
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIIGI
GO:0000122 negative regulation of transcription by RNA polymerase IIIBA
GO:0001655 urogenital system developmentIBA
GO:0001656 metanephros developmentIEP
GO:0001823 mesonephros developmentIEP
GO:0002062 chondrocyte differentiationIGI
GO:0008284 positive regulation of cell population proliferationIMP
GO:0009792 embryo development ending in birth or egg hatchingIEP
GO:0010628 positive regulation of gene expressionIMP
GO:0030154 cell differentiationIGI
GO:0030501 positive regulation of bone mineralizationIGI
GO:0033687 osteoblast proliferationIMP
GO:0035115 embryonic forelimb morphogenesisIEP
GO:0035115 embryonic forelimb morphogenesisIGI
GO:0035116 embryonic hindlimb morphogenesisIEP
GO:0035116 embryonic hindlimb morphogenesisIGI
GO:0036023 embryonic skeletal limb joint morphogenesisIGI
GO:0042474 middle ear morphogenesisIMP
GO:0042476 odontogenesisIMP
GO:0042733 embryonic digit morphogenesisIGI
GO:0045893 positive regulation of transcription, DNA-templatedIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0045944 positive regulation of transcription by RNA polymerase IIIBA
GO:0048704 embryonic skeletal system morphogenesisIMP
GO:0050679 positive regulation of epithelial cell proliferationIMP
GO:0060021 roof of mouth developmentIMP
GO:0060272 embryonic skeletal joint morphogenesisIMP
GO:0060322 head developmentIMP
GO:0060349 bone morphogenesisIMP
GO:0061029 eyelid development in camera-type eyeIMP
GO:0072498 embryonic skeletal joint developmentIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0025 Alternative splicing
KW-0479 Metal-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0677 Repeat
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2

Protein-miRNA interaction