Gene: Pygo1

Basic information

Tag Content
Uniprot ID Q9D0P5
Entrez ID 72135
Genbank protein ID BAB27468.1
Genbank nucleotide ID NM_028116.2
Ensembl protein ID ENSMUSP00000044368
Ensembl nucleotide ID ENSMUSG00000034910
Gene name Pygopus homolog 1
Gene symbol Pygo1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 17425782
Functional description Involved in signal transduction through the Wnt pathway.
Sequence
MSAEQDKEPI ALKRVRGGDS GLDGLGGPNI QLGSPDKKKR KANTQGSSFP PLSEYAPPPN 60
PNSDHLVAAN PFDDSYNTIS YKPLPSSNPY LGPGYPGFGG YSTFRMPPHV PPRMSSPYCG 120
PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP HDNSNFGNPP YNNVLTQDIN MPGQHFRQGS 180
AENFSQIPPQ NVGQVSNPDL ASNFAPGNNS NFTSPLETNH SFIPPPNAFG QAKAPLPKQD 240
FTQGATKTPN QNSSTHPPHL NMEDPVNQSN VELKNVNRNN VVQENSRSGS AEATNNHANG 300
TQNKPRQPRG AADLCTPDKS RKFSLLPSRH GHSSSDPVYP CGICTNEVND DQDAILCEAS 360
CQKWFHRICT GMTETAYGLL TAEASAVWGC DTCMADKDVQ LMRTREAFGP PAVGGDA 417

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPYGO1527394F1MHP8Bos taurusPredictionMore>>
1:1 orthologPYGO1A0A452G0X5Capra hircusPredictionMore>>
1:1 orthologPYGO126108Q9Y3Y4Homo sapiensPredictionMore>>
1:1 orthologPygo172135Q9D0P5CPOMus musculusPublicationMore>>
1:1 orthologPYGO1467804A0A2I3T6C4Pan troglodytesPredictionMore>>
1:1 orthologPYGO1100156479F1RZF2Sus scrofaPredictionMore>>
1:1 orthologPYGO1100342223G1T1W7Oryctolagus cuniculusPredictionMore>>
1:1 orthologPygo1691857F1M5T3Rattus norvegicusPredictionMore>>
1:1 orthologpygo1B7ZUU3Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0035064 methylated histone bindingISO
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001822 kidney developmentIGI
GO:0001822 kidney developmentIBA
GO:0002244 hematopoietic progenitor cell differentiationIMP
GO:0007286 spermatid developmentIGI
GO:0007289 spermatid nucleus differentiationIBA
GO:0007289 spermatid nucleus differentiationIGI
GO:0034504 protein localization to nucleusIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0048856 anatomical structure developmentIGI
GO:0060070 canonical Wnt signaling pathwayIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-195721 Signaling by WNTIEA
R-MMU-201681 TCF dependent signaling in response to WNTIEA
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complexIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0479 Metal-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0879 Wnt signaling pathway
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

PROSITE

PROSITE ID PROSITE Term
PS01359 ZF_PHD_1
PS50016 ZF_PHD_2

Pfam

Pfam ID Pfam Term
PF00628 PHD

Protein-protein interaction

Protein-miRNA interaction