| Tag | Content |
|---|---|
| Uniprot ID | Q9JJJ7; A2AC30; A2AC32; A2AC33; Q9CWT0; Q9JJJ8; Q9JJJ9; Q9JJK0; |
| Entrez ID | 53627 |
| Genbank protein ID | BAA89469.1; AAH32284.1; BAA89468.1; BAA89470.1; BAB26914.1; BAA89467.1; |
| Genbank nucleotide ID | NM_023638.4; NM_016913.4; NM_145908.4; NM_001308474.1; NM_145907.4; |
| Ensembl protein ID | ENSMUSP00000080937; ENSMUSP00000086825; ENSMUSP00000076790; ENSMUSP00000086824; |
| Ensembl nucleotide ID | ENSMUSG00000031169 |
| Gene name | Protein-serine O-palmitoleoyltransferase porcupine |
| Gene symbol | Porcn |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25451153; 21768372; |
| Functional description | Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. |
| Sequence | MATFSRQEFF QQLLQGCLLP TVQQGLDQIW LLLTICFACR LLWRLGLPSY LKHASTVAGG 60 FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW 120 HKMRGAQMIV AMKAVSLGFD LDRGEVGAVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV 180 QGRPLSRRWL KKVARSLALA LLCLVLSTCV GPYLFPYFIP LDGDRLLRNK KRKARGTMVR 240 WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSRPL NVELPRSMVE 300 VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV 360 EHVLRKRLAQ ILSACILSKR CLPDCSHRHR LGLGVRALNL LFGALAIFHL SYLGSLFDVD 420 VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G 461 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PORCN | 540373 | A7MB52 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PORCN | 480903 | A0A5F4BU92 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PORCN | 102177509 | A0A452EU12 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PORCN | 64840 | Q9H237 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Porcn | 53627 | Q9JJJ7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PORCN | A0A2J8IQT0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PORCN | 100627921 | A0A287B2I9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Porcn | 317368 | D3ZVQ3 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0008374 | O-acyltransferase activity | TAS |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:1990698 | palmitoleoyltransferase activity | TAS |
| GO:1990698 | palmitoleoyltransferase activity | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006497 | protein lipidation | IDA |
| GO:0009100 | glycoprotein metabolic process | IDA |
| GO:0016055 | Wnt signaling pathway | IMP |
| GO:0016055 | Wnt signaling pathway | IDA |
| GO:0045234 | protein palmitoleylation | IMP |
| GO:0045234 | protein palmitoleylation | IDA |
| GO:0060070 | canonical Wnt signaling pathway | IMP |
| GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | IDA |
| GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005789 | endoplasmic reticulum membrane | TAS |
| GO:0030176 | integral component of endoplasmic reticulum membrane | IDA |
| GO:0032281 | AMPA glutamate receptor complex | IDA |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| Reactome ID | Reactome Term | Evidence |
|---|
| InterPro ID | InterPro Term |
|---|---|
| IPR004299 | MBOAT_fam |
| Pfam ID | Pfam Term |
|---|---|
| PF03062 | MBOAT |