| Tag | Content |
|---|---|
| Uniprot ID | Q9R1R0; O88706; Q6P1H2; Q9R1R1; |
| Entrez ID | 16874 |
| Genbank protein ID | AAH65077.1; BAA83420.1; CAA04011.1; BAA83421.1; |
| Genbank nucleotide ID | NM_001083127.1; NM_008500.2; XM_006497744.3; XM_017315869.1; NM_001083126.1; |
| Ensembl protein ID | ENSMUSP00000135693; ENSMUSP00000108585; ENSMUSP00000108590; ENSMUSP00000108587; |
| Ensembl nucleotide ID | ENSMUSG00000026890 |
| Gene name | LIM/homeobox protein Lhx6 |
| Gene symbol | Lhx6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 19591819 |
| Functional description | Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. |
| Sequence | MAQPGSGCKA TTRCLEGTAP PAMAQSDAEA LAGALDKDEG RASPCTPSTP SVCSPPSAAS 60 SVPSAGKNIC SSCGLEILDR YLLKVNNLIW HVRCLECSVC RTSLRQQNSC YIKNKEIYCK 120 MDYFSRFGTK CARCGRQIYA SDWVRRARGN AYHLACFACF SCKRQLSTGE EFGLVEEKVL 180 CRIHYDTMIE NLKRAAENGN GLTLEGAVPS EQDSQPKPAK RARTSFTAEQ LQVMQAQFAQ 240 DNNPDAQTLQ KLADMTGLSR RVIQVWFQNC RARHKKHTPQ HPVPPSGAPP TRLPSALSDD 300 IHYSPFSSPE RARMVTLHGY IESQVQCGQV HCRLPYTAPP VHLKADLDGP LSSRGEKVIL 360 FQY 363 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LHX6 | 541261 | E1B8I6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LHX6 | E2RA99 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | LHX6 | A0A452EBF4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LHX6 | 26468 | Q9UPM6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lhx6 | 16874 | Q9R1R0 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LHX6 | 735560 | A0A2I3RGU2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Lhx6 | D3ZDG6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | lhx6 | 445565 | Q6BDC4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0003700 | DNA-binding transcription factor activity | NAS |
| GO:0005515 | protein binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0021799 | cerebral cortex radially oriented cell migration | IMP |
| GO:0021800 | cerebral cortex tangential migration | IMP |
| GO:0021853 | cerebral cortex GABAergic interneuron migration | IMP |
| GO:0021877 | forebrain neuron fate commitment | IGI |
| GO:0021884 | forebrain neuron development | IGI |
| GO:0021884 | forebrain neuron development | IBA |
| GO:0021895 | cerebral cortex neuron differentiation | IGI |
| GO:0030182 | neuron differentiation | IBA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0048469 | cell maturation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-0238 | DNA-binding |
| KW-0371 | Homeobox |
| KW-0440 | LIM domain |
| KW-0479 | Metal-binding |
| KW-0524 | Neurogenesis |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0862 | Zinc |