ERGR - Ethanol-Related Gene Resource

14 Human datasets list:

Dataset name or PMID Species Method Tissue Phenotype or Treatment Publication

11093800 Human Microarray SH-SY5Y neuroblastoma cells Ethanol response Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
11141048 Human Microarray Frontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
12065639 Human Microarray Frontal and motor cortices Alcohol dependence (AD)/Alcohol abuse/Alcoholism Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
12774316 Human Microarray Temporal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
15236863 Human Microarray Prefrontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
15816859 Human Microarray Prefrontal cortex and nucleus accumbens Alcohol dependence (AD)/Alcohol abuse/Alcoholism Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
16292326 Human Microarray Frontal cortex Alcohol dependence (AD)/Alcohol abuse/Alcoholism Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
18477577 Human Addiction array gene list Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
16894614 Human Association Alcohol dependence (AD)/Alcohol abuse/Alcoholism Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Literature search Human Literature search
15211641 Human Linkage Alcoholism phenotype along with age, gender, and P300 or constraint Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
16534506 Human Linkage ADSX (number of DSM-IV AD symptoms) Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
17067344 Human Linkage WDSFS (withdrawal symptoms factor score), ONSET (age at onset of AD), ISENS (initial sensitivity), TOLMX (tolerance/maximum drinking) Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
HuGE Navigator Human Literature data mining Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].

Dataset name or PMID	Species	Method	Tissue	Phenotype or Treatment	Publication
11093800	Human	Microarray	SH-SY5Y neuroblastoma cells	Ethanol response	Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
11141048	Human	Microarray	Frontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
12065639	Human	Microarray	Frontal and motor cortices	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
12774316	Human	Microarray	Temporal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
15236863	Human	Microarray	Prefrontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
15816859	Human	Microarray	Prefrontal cortex and nucleus accumbens	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
16292326	Human	Microarray	Frontal cortex	Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
18477577	Human	Addiction array gene list			Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
16894614	Human	Association		Alcohol dependence (AD)/Alcohol abuse/Alcoholism	Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Literature search	Human	Literature search
15211641	Human	Linkage		Alcoholism phenotype along with age, gender, and P300 or constraint	Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
16534506	Human	Linkage		ADSX (number of DSM-IV AD symptoms)	Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
17067344	Human	Linkage		WDSFS (withdrawal symptoms factor score), ONSET (age at onset of AD), ISENS (initial sensitivity), TOLMX (tolerance/maximum drinking)	Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
HuGE Navigator	Human	Literature data mining		Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism	Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].