Gene Page: BTN3A2
Summary ?
| GeneID | 11118 |
| Symbol | BTN3A2 |
| Synonyms | BT3.2|BTF4|BTN3.2|CD277 |
| Description | butyrophilin subfamily 3 member A2 |
| Reference | MIM:613594|HGNC:HGNC:1139|Ensembl:ENSG00000186470|HPRD:12547|Vega:OTTHUMG00000014450 |
| Gene type | protein-coding |
| Map location | 6p22.1 |
| Pascal p-value | 1E-12 |
| Fetal beta | -1.059 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs28551159 | 6 | 26376368 | BTN3A2 | ENSG00000186470.9 | 1.982E-6 | 0.04 | 10981 | gtex_brain_ba24 |
| rs67509210 | 6 | 26354100 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -11287 | gtex_brain_putamen_basal |
| rs9366653 | 6 | 26354247 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -11140 | gtex_brain_putamen_basal |
| rs9379851 | 6 | 26354780 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -10607 | gtex_brain_putamen_basal |
| rs35934643 | 6 | 26355094 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -10293 | gtex_brain_putamen_basal |
| rs377189555 | 6 | 26356038 | BTN3A2 | ENSG00000186470.9 | 1.146E-7 | 0 | -9349 | gtex_brain_putamen_basal |
| rs199842239 | 6 | 26356043 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -9344 | gtex_brain_putamen_basal |
| rs201843142 | 6 | 26356045 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -9342 | gtex_brain_putamen_basal |
| rs35304979 | 6 | 26356347 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -9040 | gtex_brain_putamen_basal |
| rs71557332 | 6 | 26356853 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -8534 | gtex_brain_putamen_basal |
| rs9393703 | 6 | 26356951 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -8436 | gtex_brain_putamen_basal |
| rs9358930 | 6 | 26357011 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -8376 | gtex_brain_putamen_basal |
| rs9379852 | 6 | 26357278 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -8109 | gtex_brain_putamen_basal |
| rs9379853 | 6 | 26357635 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -7752 | gtex_brain_putamen_basal |
| rs9393704 | 6 | 26358775 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -6612 | gtex_brain_putamen_basal |
| rs72836482 | 6 | 26359241 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -6146 | gtex_brain_putamen_basal |
| rs9348709 | 6 | 26360311 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -5076 | gtex_brain_putamen_basal |
| rs200156153 | 6 | 26360424 | BTN3A2 | ENSG00000186470.9 | 3.356E-8 | 0 | -4963 | gtex_brain_putamen_basal |
| rs142730696 | 6 | 26360443 | BTN3A2 | ENSG00000186470.9 | 1.024E-7 | 0 | -4944 | gtex_brain_putamen_basal |
| rs9393705 | 6 | 26361011 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -4376 | gtex_brain_putamen_basal |
| rs9393706 | 6 | 26361500 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -3887 | gtex_brain_putamen_basal |
| rs34550936 | 6 | 26361985 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -3402 | gtex_brain_putamen_basal |
| rs34622023 | 6 | 26362119 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -3268 | gtex_brain_putamen_basal |
| rs9393707 | 6 | 26362486 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -2901 | gtex_brain_putamen_basal |
| rs9393708 | 6 | 26362643 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -2744 | gtex_brain_putamen_basal |
| rs9358932 | 6 | 26362705 | BTN3A2 | ENSG00000186470.9 | 1.001E-7 | 0 | -2682 | gtex_brain_putamen_basal |
| rs9379854 | 6 | 26362854 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -2533 | gtex_brain_putamen_basal |
| rs9358934 | 6 | 26363755 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -1632 | gtex_brain_putamen_basal |
| rs9357006 | 6 | 26364628 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -759 | gtex_brain_putamen_basal |
| rs9379855 | 6 | 26364930 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | -457 | gtex_brain_putamen_basal |
| rs28362606 | 6 | 26365586 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 199 | gtex_brain_putamen_basal |
| rs58825580 | 6 | 26365679 | BTN3A2 | ENSG00000186470.9 | 8.663E-7 | 0 | 292 | gtex_brain_putamen_basal |
| rs68112369 | 6 | 26365759 | BTN3A2 | ENSG00000186470.9 | 1.737E-7 | 0 | 372 | gtex_brain_putamen_basal |
| rs66827971 | 6 | 26365766 | BTN3A2 | ENSG00000186470.9 | 1.737E-7 | 0 | 379 | gtex_brain_putamen_basal |
| rs71557334 | 6 | 26365913 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 526 | gtex_brain_putamen_basal |
| rs9348712 | 6 | 26366511 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 1124 | gtex_brain_putamen_basal |
| rs9379856 | 6 | 26366836 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 1449 | gtex_brain_putamen_basal |
| rs9379857 | 6 | 26367654 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 2267 | gtex_brain_putamen_basal |
| rs9379858 | 6 | 26367689 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 2302 | gtex_brain_putamen_basal |
| rs9393710 | 6 | 26367833 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 2446 | gtex_brain_putamen_basal |
| rs71557335 | 6 | 26368279 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 2892 | gtex_brain_putamen_basal |
| rs13191660 | 6 | 26369252 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 3865 | gtex_brain_putamen_basal |
| rs9379859 | 6 | 26369549 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 4162 | gtex_brain_putamen_basal |
| rs9358935 | 6 | 26369587 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 4200 | gtex_brain_putamen_basal |
| rs34436535 | 6 | 26370365 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 4978 | gtex_brain_putamen_basal |
| rs35307327 | 6 | 26370474 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 5087 | gtex_brain_putamen_basal |
| rs34878490 | 6 | 26370572 | BTN3A2 | ENSG00000186470.9 | 9.127E-8 | 0 | 5185 | gtex_brain_putamen_basal |
| rs9358936 | 6 | 26370657 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 5270 | gtex_brain_putamen_basal |
| rs9393711 | 6 | 26370659 | BTN3A2 | ENSG00000186470.9 | 9.809E-8 | 0 | 5272 | gtex_brain_putamen_basal |
| rs9393712 | 6 | 26371000 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 5613 | gtex_brain_putamen_basal |
| rs12173854 | 6 | 26371679 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 6292 | gtex_brain_putamen_basal |
| rs9379863 | 6 | 26372427 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7040 | gtex_brain_putamen_basal |
| rs35815698 | 6 | 26372460 | BTN3A2 | ENSG00000186470.9 | 1.032E-7 | 0 | 7073 | gtex_brain_putamen_basal |
| rs9379864 | 6 | 26372584 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7197 | gtex_brain_putamen_basal |
| rs12176317 | 6 | 26372786 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7399 | gtex_brain_putamen_basal |
| rs12174602 | 6 | 26372827 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7440 | gtex_brain_putamen_basal |
| rs12174623 | 6 | 26373086 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7699 | gtex_brain_putamen_basal |
| rs12174639 | 6 | 26373121 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7734 | gtex_brain_putamen_basal |
| rs12174631 | 6 | 26373150 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 7763 | gtex_brain_putamen_basal |
| rs13216828 | 6 | 26373507 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 8120 | gtex_brain_putamen_basal |
| rs9393713 | 6 | 26373678 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 8291 | gtex_brain_putamen_basal |
| rs9393714 | 6 | 26373740 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 8353 | gtex_brain_putamen_basal |
| rs9358937 | 6 | 26374274 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 8887 | gtex_brain_putamen_basal |
| rs2073527 | 6 | 26374978 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 9591 | gtex_brain_putamen_basal |
| rs2073529 | 6 | 26375159 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 9772 | gtex_brain_putamen_basal |
| rs2073530 | 6 | 26375243 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 9856 | gtex_brain_putamen_basal |
| rs2073531 | 6 | 26375256 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 9869 | gtex_brain_putamen_basal |
| rs9393715 | 6 | 26375645 | BTN3A2 | ENSG00000186470.9 | 1.001E-7 | 0 | 10258 | gtex_brain_putamen_basal |
| rs9348716 | 6 | 26375658 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 10271 | gtex_brain_putamen_basal |
| rs9379871 | 6 | 26375854 | BTN3A2 | ENSG00000186470.9 | 1.012E-7 | 0 | 10467 | gtex_brain_putamen_basal |
| rs3757138 | 6 | 26376103 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 10716 | gtex_brain_putamen_basal |
| rs3047288 | 6 | 26376314 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 10927 | gtex_brain_putamen_basal |
| rs28551159 | 6 | 26376368 | BTN3A2 | ENSG00000186470.9 | 6.201E-8 | 0 | 10981 | gtex_brain_putamen_basal |
| rs9366654 | 6 | 26377028 | BTN3A2 | ENSG00000186470.9 | 1.001E-7 | 0 | 11641 | gtex_brain_putamen_basal |
| rs9366655 | 6 | 26377385 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 11998 | gtex_brain_putamen_basal |
| rs1977 | 6 | 26377546 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 12159 | gtex_brain_putamen_basal |
| rs1978 | 6 | 26377573 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 12186 | gtex_brain_putamen_basal |
| rs1979 | 6 | 26377591 | BTN3A2 | ENSG00000186470.9 | 4.493E-7 | 0 | 12204 | gtex_brain_putamen_basal |
| rs68072215 | 6 | 26377927 | BTN3A2 | ENSG00000186470.9 | 1E-7 | 0 | 12540 | gtex_brain_putamen_basal |
| rs66823108 | 6 | 26377939 | BTN3A2 | ENSG00000186470.9 | 1.014E-7 | 0 | 12552 | gtex_brain_putamen_basal |
| rs72841536 | 6 | 26378288 | BTN3A2 | ENSG00000186470.9 | 1.521E-7 | 0 | 12901 | gtex_brain_putamen_basal |
| rs2072806 | 6 | 26385093 | BTN3A2 | ENSG00000186470.9 | 4.697E-7 | 0 | 19706 | gtex_brain_putamen_basal |
| rs9358938 | 6 | 26387546 | BTN3A2 | ENSG00000186470.9 | 4.697E-7 | 0 | 22159 | gtex_brain_putamen_basal |
| rs2072803 | 6 | 26392515 | BTN3A2 | ENSG00000186470.9 | 4.697E-7 | 0 | 27128 | gtex_brain_putamen_basal |
| rs9379873 | 6 | 26402717 | BTN3A2 | ENSG00000186470.9 | 4.011E-7 | 0 | 37330 | gtex_brain_putamen_basal |
| rs9393718 | 6 | 26407482 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 42095 | gtex_brain_putamen_basal |
| rs34273322 | 6 | 26415409 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 50022 | gtex_brain_putamen_basal |
| rs9358939 | 6 | 26416787 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 51400 | gtex_brain_putamen_basal |
| rs2393667 | 6 | 26421345 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 55958 | gtex_brain_putamen_basal |
| rs3734537 | 6 | 26422627 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 57240 | gtex_brain_putamen_basal |
| rs2076030 | 6 | 26426856 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 61469 | gtex_brain_putamen_basal |
| rs2235251 | 6 | 26431982 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 66595 | gtex_brain_putamen_basal |
| rs9366656 | 6 | 26434630 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 69243 | gtex_brain_putamen_basal |
| rs9379875 | 6 | 26444732 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 79345 | gtex_brain_putamen_basal |
| rs35942482 | 6 | 26444938 | BTN3A2 | ENSG00000186470.9 | 4.983E-7 | 0 | 79551 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CTTNBP2NL | 0.95 | 0.94 |
| RBM9 | 0.95 | 0.96 |
| CSRNP2 | 0.94 | 0.95 |
| PAK7 | 0.94 | 0.96 |
| KLF7 | 0.94 | 0.95 |
| TNPO3 | 0.94 | 0.95 |
| FAM117B | 0.93 | 0.95 |
| RFX7 | 0.93 | 0.94 |
| KIDINS220 | 0.93 | 0.94 |
| BCORL1 | 0.93 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AIFM3 | -0.73 | -0.83 |
| C5orf53 | -0.72 | -0.80 |
| HEPN1 | -0.72 | -0.81 |
| SERPINB6 | -0.71 | -0.77 |
| TSC22D4 | -0.71 | -0.83 |
| AF347015.31 | -0.71 | -0.91 |
| HLA-F | -0.70 | -0.78 |
| S100B | -0.70 | -0.87 |
| ALDOC | -0.70 | -0.74 |
| AF347015.27 | -0.69 | -0.89 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003674 | molecular_function | ND | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008150 | biological_process | ND | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| THUM SYSTOLIC HEART FAILURE UP | 423 | 283 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| BASAKI YBX1 TARGETS DN | 384 | 230 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL CURED VS FATAL DN | 45 | 30 | All SZGR 2.0 genes in this pathway |
| FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP | 151 | 100 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| EHRLICH ICF SYNDROM DN | 15 | 13 | All SZGR 2.0 genes in this pathway |
| GHO ATF5 TARGETS DN | 16 | 10 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION DN | 281 | 179 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| HUANG DASATINIB RESISTANCE UP | 81 | 53 | All SZGR 2.0 genes in this pathway |
| NUTT GBM VS AO GLIOMA UP | 46 | 34 | All SZGR 2.0 genes in this pathway |
| RUIZ TNC TARGETS UP | 153 | 107 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G1 DN | 40 | 26 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 30MIN DN | 150 | 99 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |