Gene Page: CHRNA5
Summary ?
| GeneID | 1138 |
| Symbol | CHRNA5 |
| Synonyms | LNCR2 |
| Description | cholinergic receptor nicotinic alpha 5 subunit |
| Reference | MIM:118505|HGNC:HGNC:1959|Ensembl:ENSG00000169684|HPRD:00334|Vega:OTTHUMG00000143858 |
| Gene type | protein-coding |
| Map location | 15q24 |
| Pascal p-value | 1.286E-7 |
| Sherlock p-value | 0.411 |
| Fetal beta | 1.197 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGC128 | Genome-wide Association Study | A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 4 |
Section I. Genetics and epigenetics annotation
CV:PGC128
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs190065944 | chr15 | 78859610 | AG | 7.221E-8 | intronic | CHRNA5 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs5022780 | 15 | 78808235 | CHRNA5 | ENSG00000169684.9 | 4.165E-11 | 0 | -49627 | gtex_brain_ba24 |
| rs62008174 | 15 | 78808947 | CHRNA5 | ENSG00000169684.9 | 7.013E-12 | 0 | -48915 | gtex_brain_ba24 |
| rs12910978 | 15 | 78810017 | CHRNA5 | ENSG00000169684.9 | 7.017E-12 | 0 | -47845 | gtex_brain_ba24 |
| rs12912673 | 15 | 78810216 | CHRNA5 | ENSG00000169684.9 | 7.019E-12 | 0 | -47646 | gtex_brain_ba24 |
| rs12913173 | 15 | 78810546 | CHRNA5 | ENSG00000169684.9 | 9.348E-12 | 0 | -47316 | gtex_brain_ba24 |
| rs12912022 | 15 | 78810585 | CHRNA5 | ENSG00000169684.9 | 6.013E-12 | 0 | -47277 | gtex_brain_ba24 |
| rs12591557 | 15 | 78811732 | CHRNA5 | ENSG00000169684.9 | 7.011E-12 | 0 | -46130 | gtex_brain_ba24 |
| rs62008193 | 15 | 78813334 | CHRNA5 | ENSG00000169684.9 | 4.596E-10 | 0 | -44528 | gtex_brain_ba24 |
| rs62008194 | 15 | 78813805 | CHRNA5 | ENSG00000169684.9 | 7.025E-12 | 0 | -44057 | gtex_brain_ba24 |
| rs12914694 | 15 | 78814444 | CHRNA5 | ENSG00000169684.9 | 7.044E-12 | 0 | -43418 | gtex_brain_ba24 |
| rs12900783 | 15 | 78815523 | CHRNA5 | ENSG00000169684.9 | 7.045E-12 | 0 | -42339 | gtex_brain_ba24 |
| rs12594391 | 15 | 78816240 | CHRNA5 | ENSG00000169684.9 | 6.853E-12 | 0 | -41622 | gtex_brain_ba24 |
| rs12910969 | 15 | 78816980 | CHRNA5 | ENSG00000169684.9 | 6.858E-12 | 0 | -40882 | gtex_brain_ba24 |
| rs12910726 | 15 | 78817034 | CHRNA5 | ENSG00000169684.9 | 6.829E-12 | 0 | -40828 | gtex_brain_ba24 |
| rs1504545 | 15 | 78818471 | CHRNA5 | ENSG00000169684.9 | 7.346E-12 | 0 | -39391 | gtex_brain_ba24 |
| rs952215 | 15 | 78819153 | CHRNA5 | ENSG00000169684.9 | 7.813E-12 | 0 | -38709 | gtex_brain_ba24 |
| rs952216 | 15 | 78819202 | CHRNA5 | ENSG00000169684.9 | 7.853E-12 | 0 | -38660 | gtex_brain_ba24 |
| rs12902493 | 15 | 78819275 | CHRNA5 | ENSG00000169684.9 | 7.917E-12 | 0 | -38587 | gtex_brain_ba24 |
| rs12903129 | 15 | 78819606 | CHRNA5 | ENSG00000169684.9 | 8.191E-12 | 0 | -38256 | gtex_brain_ba24 |
| rs11636131 | 15 | 78821606 | CHRNA5 | ENSG00000169684.9 | 1.084E-11 | 0 | -36256 | gtex_brain_ba24 |
| rs11632604 | 15 | 78821914 | CHRNA5 | ENSG00000169684.9 | 1.13E-11 | 0 | -35948 | gtex_brain_ba24 |
| rs12910289 | 15 | 78822065 | CHRNA5 | ENSG00000169684.9 | 1.198E-11 | 0 | -35797 | gtex_brain_ba24 |
| rs35773115 | 15 | 78822189 | CHRNA5 | ENSG00000169684.9 | 4.176E-10 | 0 | -35673 | gtex_brain_ba24 |
| rs2869055 | 15 | 78822388 | CHRNA5 | ENSG00000169684.9 | 1.17E-11 | 0 | -35474 | gtex_brain_ba24 |
| rs12910100 | 15 | 78822667 | CHRNA5 | ENSG00000169684.9 | 1.208E-11 | 0 | -35195 | gtex_brain_ba24 |
| rs12915428 | 15 | 78823368 | CHRNA5 | ENSG00000169684.9 | 1.254E-11 | 0 | -34494 | gtex_brain_ba24 |
| rs12900612 | 15 | 78823993 | CHRNA5 | ENSG00000169684.9 | 1.29E-11 | 0 | -33869 | gtex_brain_ba24 |
| rs1847530 | 15 | 78824031 | CHRNA5 | ENSG00000169684.9 | 1.3E-11 | 0 | -33831 | gtex_brain_ba24 |
| rs1504546 | 15 | 78824235 | CHRNA5 | ENSG00000169684.9 | 1.314E-11 | 0 | -33627 | gtex_brain_ba24 |
| rs145042403 | 15 | 78824287 | CHRNA5 | ENSG00000169684.9 | 1.316E-11 | 0 | -33575 | gtex_brain_ba24 |
| rs11630349 | 15 | 78824608 | CHRNA5 | ENSG00000169684.9 | 1.327E-11 | 0 | -33254 | gtex_brain_ba24 |
| rs12906284 | 15 | 78825105 | CHRNA5 | ENSG00000169684.9 | 1.341E-11 | 0 | -32757 | gtex_brain_ba24 |
| rs12907425 | 15 | 78825149 | CHRNA5 | ENSG00000169684.9 | 1.341E-11 | 0 | -32713 | gtex_brain_ba24 |
| rs12906846 | 15 | 78825295 | CHRNA5 | ENSG00000169684.9 | 1.346E-11 | 0 | -32567 | gtex_brain_ba24 |
| rs12907169 | 15 | 78825498 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -32364 | gtex_brain_ba24 |
| rs12906951 | 15 | 78825562 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -32300 | gtex_brain_ba24 |
| rs56007453 | 15 | 78826239 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -31623 | gtex_brain_ba24 |
| rs17407257 | 15 | 78826249 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -31613 | gtex_brain_ba24 |
| rs12916999 | 15 | 78826912 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -30950 | gtex_brain_ba24 |
| rs12915366 | 15 | 78831753 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -26109 | gtex_brain_ba24 |
| rs12915652 | 15 | 78831928 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -25934 | gtex_brain_ba24 |
| rs12916483 | 15 | 78832397 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -25465 | gtex_brain_ba24 |
| rs3813572 | 15 | 78832588 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -25274 | gtex_brain_ba24 |
| rs3813571 | 15 | 78832792 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -25070 | gtex_brain_ba24 |
| rs55690619 | 15 | 78833612 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -24250 | gtex_brain_ba24 |
| rs4886571 | 15 | 78833758 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -24104 | gtex_brain_ba24 |
| rs4243083 | 15 | 78833830 | CHRNA5 | ENSG00000169684.9 | 3.507E-12 | 0 | -24032 | gtex_brain_ba24 |
| rs2292117 | 15 | 78834689 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -23173 | gtex_brain_ba24 |
| rs11858230 | 15 | 78835552 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -22310 | gtex_brain_ba24 |
| rs28438420 | 15 | 78836288 | CHRNA5 | ENSG00000169684.9 | 1.517E-13 | 0 | -21574 | gtex_brain_ba24 |
| rs8025429 | 15 | 78836362 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -21500 | gtex_brain_ba24 |
| rs67437837 | 15 | 78836631 | CHRNA5 | ENSG00000169684.9 | 3.079E-12 | 0 | -21231 | gtex_brain_ba24 |
| rs76712448 | 15 | 78836719 | CHRNA5 | ENSG00000169684.9 | 8.68E-11 | 0 | -21143 | gtex_brain_ba24 |
| rs75754317 | 15 | 78836721 | CHRNA5 | ENSG00000169684.9 | 8.656E-11 | 0 | -21141 | gtex_brain_ba24 |
| rs78406067 | 15 | 78836723 | CHRNA5 | ENSG00000169684.9 | 8.656E-11 | 0 | -21139 | gtex_brain_ba24 |
| rs77434238 | 15 | 78836726 | CHRNA5 | ENSG00000169684.9 | 8.656E-11 | 0 | -21136 | gtex_brain_ba24 |
| rs28392948 | 15 | 78836866 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -20996 | gtex_brain_ba24 |
| rs4886572 | 15 | 78837452 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -20410 | gtex_brain_ba24 |
| rs4887062 | 15 | 78837801 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -20061 | gtex_brain_ba24 |
| rs2869544 | 15 | 78839400 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -18462 | gtex_brain_ba24 |
| rs4887063 | 15 | 78839715 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -18147 | gtex_brain_ba24 |
| rs8053 | 15 | 78841220 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -16642 | gtex_brain_ba24 |
| rs1979907 | 15 | 78842239 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -15623 | gtex_brain_ba24 |
| rs1979906 | 15 | 78842289 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -15573 | gtex_brain_ba24 |
| rs1979905 | 15 | 78842374 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -15488 | gtex_brain_ba24 |
| rs397760194 | 15 | 78842835 | CHRNA5 | ENSG00000169684.9 | 4.697E-14 | 0 | -15027 | gtex_brain_ba24 |
| rs4887064 | 15 | 78842847 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -15015 | gtex_brain_ba24 |
| rs12907966 | 15 | 78843051 | CHRNA5 | ENSG00000169684.9 | 1.354E-11 | 0 | -14811 | gtex_brain_ba24 |
| rs1504548 | 15 | 78843246 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -14616 | gtex_brain_ba24 |
| rs1979908 | 15 | 78843564 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -14298 | gtex_brain_ba24 |
| rs880395 | 15 | 78844356 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -13506 | gtex_brain_ba24 |
| rs905740 | 15 | 78844386 | CHRNA5 | ENSG00000169684.9 | 2.991E-12 | 0 | -13476 | gtex_brain_ba24 |
| rs7164030 | 15 | 78844661 | CHRNA5 | ENSG00000169684.9 | 3.018E-12 | 0 | -13201 | gtex_brain_ba24 |
| rs4275821 | 15 | 78849541 | CHRNA5 | ENSG00000169684.9 | 1.84E-8 | 0 | -8321 | gtex_brain_ba24 |
| rs7173512 | 15 | 78849914 | CHRNA5 | ENSG00000169684.9 | 1.825E-8 | 0 | -7948 | gtex_brain_ba24 |
| rs3829787 | 15 | 78856266 | CHRNA5 | ENSG00000169684.9 | 5.144E-8 | 0 | -1596 | gtex_brain_ba24 |
| rs67624739 | 15 | 78857812 | CHRNA5 | ENSG00000169684.9 | 3.08E-10 | 0 | -50 | gtex_brain_ba24 |
| rs871058 | 15 | 78858491 | CHRNA5 | ENSG00000169684.9 | 1.333E-6 | 0 | 629 | gtex_brain_ba24 |
| rs57945453 | 15 | 78862845 | CHRNA5 | ENSG00000169684.9 | 1.218E-8 | 0 | 4983 | gtex_brain_ba24 |
| rs588765 | 15 | 78865425 | CHRNA5 | ENSG00000169684.9 | 1.642E-12 | 0 | 7563 | gtex_brain_ba24 |
| rs61012457 | 15 | 78865694 | CHRNA5 | ENSG00000169684.9 | 1.436E-8 | 0 | 7832 | gtex_brain_ba24 |
| rs6495306 | 15 | 78865893 | CHRNA5 | ENSG00000169684.9 | 1.728E-12 | 0 | 8031 | gtex_brain_ba24 |
| rs2456019 | 15 | 78868489 | CHRNA5 | ENSG00000169684.9 | 6.498E-9 | 0 | 10627 | gtex_brain_ba24 |
| rs601079 | 15 | 78869579 | CHRNA5 | ENSG00000169684.9 | 2.571E-12 | 0 | 11717 | gtex_brain_ba24 |
| rs495956 | 15 | 78869930 | CHRNA5 | ENSG00000169684.9 | 5.878E-9 | 0 | 12068 | gtex_brain_ba24 |
| rs495090 | 15 | 78870003 | CHRNA5 | ENSG00000169684.9 | 5.894E-9 | 0 | 12141 | gtex_brain_ba24 |
| rs471889 | 15 | 78870235 | CHRNA5 | ENSG00000169684.9 | 5.971E-9 | 0 | 12373 | gtex_brain_ba24 |
| rs680244 | 15 | 78871288 | CHRNA5 | ENSG00000169684.9 | 3.093E-12 | 0 | 13426 | gtex_brain_ba24 |
| rs10709956 | 15 | 78872834 | CHRNA5 | ENSG00000169684.9 | 9.079E-12 | 0 | 14972 | gtex_brain_ba24 |
| rs621849 | 15 | 78872861 | CHRNA5 | ENSG00000169684.9 | 3.093E-12 | 0 | 14999 | gtex_brain_ba24 |
| rs692780 | 15 | 78876505 | CHRNA5 | ENSG00000169684.9 | 6.325E-9 | 0 | 18643 | gtex_brain_ba24 |
| rs11637635 | 15 | 78877150 | CHRNA5 | ENSG00000169684.9 | 6.325E-9 | 0 | 19288 | gtex_brain_ba24 |
| rs481134 | 15 | 78877563 | CHRNA5 | ENSG00000169684.9 | 3.19E-12 | 0 | 19701 | gtex_brain_ba24 |
| rs5813927 | 15 | 78878100 | CHRNA5 | ENSG00000169684.9 | 3.335E-12 | 0 | 20238 | gtex_brain_ba24 |
| rs555018 | 15 | 78879242 | CHRNA5 | ENSG00000169684.9 | 1.897E-11 | 0 | 21380 | gtex_brain_ba24 |
| rs647041 | 15 | 78880481 | CHRNA5 | ENSG00000169684.9 | 2.502E-10 | 0 | 22619 | gtex_brain_ba24 |
| rs17408276 | 15 | 78881618 | CHRNA5 | ENSG00000169684.9 | 9.942E-7 | 0 | 23756 | gtex_brain_ba24 |
| rs584135 | 15 | 78883628 | CHRNA5 | ENSG00000169684.9 | 4.948E-7 | 0 | 25766 | gtex_brain_ba24 |
| rs514743 | 15 | 78884227 | CHRNA5 | ENSG00000169684.9 | 3.256E-7 | 0 | 26365 | gtex_brain_ba24 |
| rs615470 | 15 | 78885988 | CHRNA5 | ENSG00000169684.9 | 3.256E-7 | 0 | 28126 | gtex_brain_ba24 |
| rs660652 | 15 | 78887832 | CHRNA5 | ENSG00000169684.9 | 7.54E-7 | 0 | 29970 | gtex_brain_ba24 |
| rs472054 | 15 | 78887994 | CHRNA5 | ENSG00000169684.9 | 7.54E-7 | 0 | 30132 | gtex_brain_ba24 |
| rs398057851 | 15 | 78889782 | CHRNA5 | ENSG00000169684.9 | 4.153E-10 | 0 | 31920 | gtex_brain_ba24 |
| rs6495307 | 15 | 78890321 | CHRNA5 | ENSG00000169684.9 | 4.153E-10 | 0 | 32459 | gtex_brain_ba24 |
| rs12911602 | 15 | 78891449 | CHRNA5 | ENSG00000169684.9 | 4.153E-10 | 0 | 33587 | gtex_brain_ba24 |
| rs62010327 | 15 | 78892784 | CHRNA5 | ENSG00000169684.9 | 7.438E-7 | 0 | 34922 | gtex_brain_ba24 |
| rs12901300 | 15 | 78892952 | CHRNA5 | ENSG00000169684.9 | 4.153E-10 | 0 | 35090 | gtex_brain_ba24 |
| rs3743077 | 15 | 78894896 | CHRNA5 | ENSG00000169684.9 | 2.594E-9 | 0 | 37034 | gtex_brain_ba24 |
| rs75104798 | 15 | 78897865 | CHRNA5 | ENSG00000169684.9 | 2.074E-7 | 0 | 40003 | gtex_brain_ba24 |
| rs7182583 | 15 | 78899210 | CHRNA5 | ENSG00000169684.9 | 3.259E-7 | 0 | 41348 | gtex_brain_ba24 |
| rs111725959 | 15 | 78899346 | CHRNA5 | ENSG00000169684.9 | 1.254E-6 | 0 | 41484 | gtex_brain_ba24 |
| rs139978901 | 15 | 78902026 | CHRNA5 | ENSG00000169684.9 | 9.66E-8 | 0 | 44164 | gtex_brain_ba24 |
| rs183822442 | 15 | 78902775 | CHRNA5 | ENSG00000169684.9 | 6.664E-9 | 0 | 44913 | gtex_brain_ba24 |
| rs190259891 | 15 | 78902906 | CHRNA5 | ENSG00000169684.9 | 3.071E-9 | 0 | 45044 | gtex_brain_ba24 |
| rs77403874 | 15 | 78903165 | CHRNA5 | ENSG00000169684.9 | 4.153E-10 | 0 | 45303 | gtex_brain_ba24 |
| rs147094383 | 15 | 78903997 | CHRNA5 | ENSG00000169684.9 | 5.057E-7 | 0 | 46135 | gtex_brain_ba24 |
| rs200722258 | 15 | 78906118 | CHRNA5 | ENSG00000169684.9 | 1.854E-7 | 0 | 48256 | gtex_brain_ba24 |
| rs9646187 | 15 | 78906128 | CHRNA5 | ENSG00000169684.9 | 1.665E-7 | 0 | 48266 | gtex_brain_ba24 |
| rs2869546 | 15 | 78907345 | CHRNA5 | ENSG00000169684.9 | 4.211E-8 | 0 | 49483 | gtex_brain_ba24 |
| rs3743074 | 15 | 78909480 | CHRNA5 | ENSG00000169684.9 | 3.509E-7 | 0 | 51618 | gtex_brain_ba24 |
| rs3743073 | 15 | 78909539 | CHRNA5 | ENSG00000169684.9 | 3.509E-7 | 0 | 51677 | gtex_brain_ba24 |
| rs2067808 | 15 | 78911780 | CHRNA5 | ENSG00000169684.9 | 1.256E-6 | 0 | 53918 | gtex_brain_ba24 |
| rs1878399 | 15 | 78912003 | CHRNA5 | ENSG00000169684.9 | 1.355E-9 | 0 | 54141 | gtex_brain_ba24 |
| rs201576627 | 15 | 78912201 | CHRNA5 | ENSG00000169684.9 | 4.466E-10 | 0 | 54339 | gtex_brain_ba24 |
| rs4366683 | 15 | 78912203 | CHRNA5 | ENSG00000169684.9 | 4.508E-10 | 0 | 54341 | gtex_brain_ba24 |
| rs386419558 | 15 | 78912203 | CHRNA5 | ENSG00000169684.9 | 8.672E-10 | 0 | 54341 | gtex_brain_ba24 |
| rs4352017 | 15 | 78912204 | CHRNA5 | ENSG00000169684.9 | 1.353E-9 | 0 | 54342 | gtex_brain_ba24 |
| rs8025188 | 15 | 78912278 | CHRNA5 | ENSG00000169684.9 | 4.078E-10 | 0 | 54416 | gtex_brain_ba24 |
| rs8023462 | 15 | 78914734 | CHRNA5 | ENSG00000169684.9 | 2.855E-7 | 0 | 56872 | gtex_brain_ba24 |
| rs4887070 | 15 | 78916187 | CHRNA5 | ENSG00000169684.9 | 6.323E-7 | 0 | 58325 | gtex_brain_ba24 |
| rs2904130 | 15 | 78916622 | CHRNA5 | ENSG00000169684.9 | 6.782E-7 | 0 | 58760 | gtex_brain_ba24 |
| rs7178270 | 15 | 78921077 | CHRNA5 | ENSG00000169684.9 | 7.615E-9 | 0 | 63215 | gtex_brain_ba24 |
| rs11636753 | 15 | 78928946 | CHRNA5 | ENSG00000169684.9 | 9.655E-7 | 0 | 71084 | gtex_brain_ba24 |
| rs57728226 | 15 | 78929350 | CHRNA5 | ENSG00000169684.9 | 2.36E-7 | 0 | 71488 | gtex_brain_ba24 |
| rs36045869 | 15 | 78929498 | CHRNA5 | ENSG00000169684.9 | 2.3E-7 | 0 | 71636 | gtex_brain_ba24 |
| rs11637890 | 15 | 78935419 | CHRNA5 | ENSG00000169684.9 | 1.016E-7 | 0 | 77557 | gtex_brain_ba24 |
| rs11633223 | 15 | 78935476 | CHRNA5 | ENSG00000169684.9 | 5.598E-8 | 0 | 77614 | gtex_brain_ba24 |
| rs4436747 | 15 | 78714008 | CHRNA5 | ENSG00000169684.9 | 1.027E-6 | 0 | -143854 | gtex_brain_putamen_basal |
| rs11632223 | 15 | 78716350 | CHRNA5 | ENSG00000169684.9 | 1.134E-6 | 0 | -141512 | gtex_brain_putamen_basal |
| rs4381564 | 15 | 78717753 | CHRNA5 | ENSG00000169684.9 | 2.319E-6 | 0 | -140109 | gtex_brain_putamen_basal |
| rs2869046 | 15 | 78720966 | CHRNA5 | ENSG00000169684.9 | 6.45E-8 | 0 | -136896 | gtex_brain_putamen_basal |
| rs11072762 | 15 | 78721445 | CHRNA5 | ENSG00000169684.9 | 1.421E-7 | 0 | -136417 | gtex_brain_putamen_basal |
| rs12916769 | 15 | 78723347 | CHRNA5 | ENSG00000169684.9 | 1.676E-6 | 0 | -134515 | gtex_brain_putamen_basal |
| rs12903150 | 15 | 78724645 | CHRNA5 | ENSG00000169684.9 | 1.676E-6 | 0 | -133217 | gtex_brain_putamen_basal |
| rs12908534 | 15 | 78725521 | CHRNA5 | ENSG00000169684.9 | 1.674E-6 | 0 | -132341 | gtex_brain_putamen_basal |
| rs12899425 | 15 | 78726836 | CHRNA5 | ENSG00000169684.9 | 1.685E-6 | 0 | -131026 | gtex_brain_putamen_basal |
| rs12899131 | 15 | 78726885 | CHRNA5 | ENSG00000169684.9 | 3.932E-7 | 0 | -130977 | gtex_brain_putamen_basal |
| rs2568500 | 15 | 78726928 | CHRNA5 | ENSG00000169684.9 | 3.225E-7 | 0 | -130934 | gtex_brain_putamen_basal |
| rs2036532 | 15 | 78727386 | CHRNA5 | ENSG00000169684.9 | 3.889E-7 | 0 | -130476 | gtex_brain_putamen_basal |
| rs954144 | 15 | 78730591 | CHRNA5 | ENSG00000169684.9 | 3.682E-7 | 0 | -127271 | gtex_brain_putamen_basal |
| rs11072765 | 15 | 78734292 | CHRNA5 | ENSG00000169684.9 | 2.054E-7 | 0 | -123570 | gtex_brain_putamen_basal |
| rs1847529 | 15 | 78735070 | CHRNA5 | ENSG00000169684.9 | 3.474E-7 | 0 | -122792 | gtex_brain_putamen_basal |
| rs8041628 | 15 | 78735355 | CHRNA5 | ENSG00000169684.9 | 3.475E-7 | 0 | -122507 | gtex_brain_putamen_basal |
| rs11630115 | 15 | 78736184 | CHRNA5 | ENSG00000169684.9 | 1.677E-6 | 0 | -121678 | gtex_brain_putamen_basal |
| rs11630228 | 15 | 78736325 | CHRNA5 | ENSG00000169684.9 | 1.677E-6 | 0 | -121537 | gtex_brain_putamen_basal |
| rs10519198 | 15 | 78742754 | CHRNA5 | ENSG00000169684.9 | 3.474E-7 | 0 | -115108 | gtex_brain_putamen_basal |
| rs12909921 | 15 | 78743260 | CHRNA5 | ENSG00000169684.9 | 3.474E-7 | 0 | -114602 | gtex_brain_putamen_basal |
| rs12910090 | 15 | 78743300 | CHRNA5 | ENSG00000169684.9 | 3.474E-7 | 0 | -114562 | gtex_brain_putamen_basal |
| rs12916396 | 15 | 78744524 | CHRNA5 | ENSG00000169684.9 | 1.677E-6 | 0 | -113338 | gtex_brain_putamen_basal |
| rs12916558 | 15 | 78744600 | CHRNA5 | ENSG00000169684.9 | 1.677E-6 | 0 | -113262 | gtex_brain_putamen_basal |
| rs11639224 | 15 | 78753371 | CHRNA5 | ENSG00000169684.9 | 3.474E-7 | 0 | -104491 | gtex_brain_putamen_basal |
| rs11636431 | 15 | 78788500 | CHRNA5 | ENSG00000169684.9 | 1.551E-6 | 0 | -69362 | gtex_brain_putamen_basal |
| rs5022780 | 15 | 78808235 | CHRNA5 | ENSG00000169684.9 | 6.906E-10 | 0 | -49627 | gtex_brain_putamen_basal |
| rs62008174 | 15 | 78808947 | CHRNA5 | ENSG00000169684.9 | 7.188E-11 | 0 | -48915 | gtex_brain_putamen_basal |
| rs12910978 | 15 | 78810017 | CHRNA5 | ENSG00000169684.9 | 6.968E-11 | 0 | -47845 | gtex_brain_putamen_basal |
| rs12912673 | 15 | 78810216 | CHRNA5 | ENSG00000169684.9 | 6.936E-11 | 0 | -47646 | gtex_brain_putamen_basal |
| rs12913173 | 15 | 78810546 | CHRNA5 | ENSG00000169684.9 | 4.359E-11 | 0 | -47316 | gtex_brain_putamen_basal |
| rs12912022 | 15 | 78810585 | CHRNA5 | ENSG00000169684.9 | 2.849E-11 | 0 | -47277 | gtex_brain_putamen_basal |
| rs12591557 | 15 | 78811732 | CHRNA5 | ENSG00000169684.9 | 6.637E-11 | 0 | -46130 | gtex_brain_putamen_basal |
| rs62008193 | 15 | 78813334 | CHRNA5 | ENSG00000169684.9 | 1.007E-9 | 0 | -44528 | gtex_brain_putamen_basal |
| rs62008194 | 15 | 78813805 | CHRNA5 | ENSG00000169684.9 | 6.305E-11 | 0 | -44057 | gtex_brain_putamen_basal |
| rs12914694 | 15 | 78814444 | CHRNA5 | ENSG00000169684.9 | 1.141E-10 | 0 | -43418 | gtex_brain_putamen_basal |
| rs12900783 | 15 | 78815523 | CHRNA5 | ENSG00000169684.9 | 3.423E-11 | 0 | -42339 | gtex_brain_putamen_basal |
| rs12594391 | 15 | 78816240 | CHRNA5 | ENSG00000169684.9 | 3.408E-11 | 0 | -41622 | gtex_brain_putamen_basal |
| rs12910969 | 15 | 78816980 | CHRNA5 | ENSG00000169684.9 | 3.383E-11 | 0 | -40882 | gtex_brain_putamen_basal |
| rs12910726 | 15 | 78817034 | CHRNA5 | ENSG00000169684.9 | 3.329E-11 | 0 | -40828 | gtex_brain_putamen_basal |
| rs1504545 | 15 | 78818471 | CHRNA5 | ENSG00000169684.9 | 3.348E-11 | 0 | -39391 | gtex_brain_putamen_basal |
| rs952215 | 15 | 78819153 | CHRNA5 | ENSG00000169684.9 | 3.342E-11 | 0 | -38709 | gtex_brain_putamen_basal |
| rs952216 | 15 | 78819202 | CHRNA5 | ENSG00000169684.9 | 3.341E-11 | 0 | -38660 | gtex_brain_putamen_basal |
| rs12902493 | 15 | 78819275 | CHRNA5 | ENSG00000169684.9 | 3.34E-11 | 0 | -38587 | gtex_brain_putamen_basal |
| rs12903129 | 15 | 78819606 | CHRNA5 | ENSG00000169684.9 | 3.328E-11 | 0 | -38256 | gtex_brain_putamen_basal |
| rs11636131 | 15 | 78821606 | CHRNA5 | ENSG00000169684.9 | 3.303E-11 | 0 | -36256 | gtex_brain_putamen_basal |
| rs11632604 | 15 | 78821914 | CHRNA5 | ENSG00000169684.9 | 3.305E-11 | 0 | -35948 | gtex_brain_putamen_basal |
| rs12910289 | 15 | 78822065 | CHRNA5 | ENSG00000169684.9 | 3.544E-11 | 0 | -35797 | gtex_brain_putamen_basal |
| rs35773115 | 15 | 78822189 | CHRNA5 | ENSG00000169684.9 | 5.402E-9 | 0 | -35673 | gtex_brain_putamen_basal |
| rs2869055 | 15 | 78822388 | CHRNA5 | ENSG00000169684.9 | 2.639E-8 | 0 | -35474 | gtex_brain_putamen_basal |
| rs12910100 | 15 | 78822667 | CHRNA5 | ENSG00000169684.9 | 3.306E-11 | 0 | -35195 | gtex_brain_putamen_basal |
| rs12915428 | 15 | 78823368 | CHRNA5 | ENSG00000169684.9 | 3.308E-11 | 0 | -34494 | gtex_brain_putamen_basal |
| rs12900612 | 15 | 78823993 | CHRNA5 | ENSG00000169684.9 | 3.193E-11 | 0 | -33869 | gtex_brain_putamen_basal |
| rs1847530 | 15 | 78824031 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -33831 | gtex_brain_putamen_basal |
| rs1504546 | 15 | 78824235 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -33627 | gtex_brain_putamen_basal |
| rs145042403 | 15 | 78824287 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -33575 | gtex_brain_putamen_basal |
| rs11630349 | 15 | 78824608 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -33254 | gtex_brain_putamen_basal |
| rs12906284 | 15 | 78825105 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -32757 | gtex_brain_putamen_basal |
| rs12907425 | 15 | 78825149 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -32713 | gtex_brain_putamen_basal |
| rs12906846 | 15 | 78825295 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -32567 | gtex_brain_putamen_basal |
| rs12907169 | 15 | 78825498 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -32364 | gtex_brain_putamen_basal |
| rs12906951 | 15 | 78825562 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -32300 | gtex_brain_putamen_basal |
| rs56007453 | 15 | 78826239 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -31623 | gtex_brain_putamen_basal |
| rs17407257 | 15 | 78826249 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -31613 | gtex_brain_putamen_basal |
| rs12916999 | 15 | 78826912 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -30950 | gtex_brain_putamen_basal |
| rs12915366 | 15 | 78831753 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -26109 | gtex_brain_putamen_basal |
| rs12915652 | 15 | 78831928 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -25934 | gtex_brain_putamen_basal |
| rs12916483 | 15 | 78832397 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -25465 | gtex_brain_putamen_basal |
| rs3813572 | 15 | 78832588 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -25274 | gtex_brain_putamen_basal |
| rs3813571 | 15 | 78832792 | CHRNA5 | ENSG00000169684.9 | 3.309E-11 | 0 | -25070 | gtex_brain_putamen_basal |
| rs55690619 | 15 | 78833612 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -24250 | gtex_brain_putamen_basal |
| rs4886571 | 15 | 78833758 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -24104 | gtex_brain_putamen_basal |
| rs4243083 | 15 | 78833830 | CHRNA5 | ENSG00000169684.9 | 1.943E-12 | 0 | -24032 | gtex_brain_putamen_basal |
| rs2292117 | 15 | 78834689 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -23173 | gtex_brain_putamen_basal |
| rs11858230 | 15 | 78835552 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -22310 | gtex_brain_putamen_basal |
| rs28438420 | 15 | 78836288 | CHRNA5 | ENSG00000169684.9 | 4.357E-9 | 0 | -21574 | gtex_brain_putamen_basal |
| rs8025429 | 15 | 78836362 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -21500 | gtex_brain_putamen_basal |
| rs67437837 | 15 | 78836631 | CHRNA5 | ENSG00000169684.9 | 1.979E-12 | 0 | -21231 | gtex_brain_putamen_basal |
| rs76712448 | 15 | 78836719 | CHRNA5 | ENSG00000169684.9 | 2.707E-12 | 0 | -21143 | gtex_brain_putamen_basal |
| rs75754317 | 15 | 78836721 | CHRNA5 | ENSG00000169684.9 | 2.533E-12 | 0 | -21141 | gtex_brain_putamen_basal |
| rs78406067 | 15 | 78836723 | CHRNA5 | ENSG00000169684.9 | 2.533E-12 | 0 | -21139 | gtex_brain_putamen_basal |
| rs77434238 | 15 | 78836726 | CHRNA5 | ENSG00000169684.9 | 2.312E-12 | 0 | -21136 | gtex_brain_putamen_basal |
| rs28392948 | 15 | 78836866 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -20996 | gtex_brain_putamen_basal |
| rs4886572 | 15 | 78837452 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -20410 | gtex_brain_putamen_basal |
| rs4887062 | 15 | 78837801 | CHRNA5 | ENSG00000169684.9 | 1.927E-12 | 0 | -20061 | gtex_brain_putamen_basal |
| rs2869544 | 15 | 78839400 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -18462 | gtex_brain_putamen_basal |
| rs4887063 | 15 | 78839715 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -18147 | gtex_brain_putamen_basal |
| rs8053 | 15 | 78841220 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -16642 | gtex_brain_putamen_basal |
| rs1979907 | 15 | 78842239 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -15623 | gtex_brain_putamen_basal |
| rs1979906 | 15 | 78842289 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -15573 | gtex_brain_putamen_basal |
| rs1979905 | 15 | 78842374 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -15488 | gtex_brain_putamen_basal |
| rs397760194 | 15 | 78842835 | CHRNA5 | ENSG00000169684.9 | 2.471E-11 | 0 | -15027 | gtex_brain_putamen_basal |
| rs4887064 | 15 | 78842847 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -15015 | gtex_brain_putamen_basal |
| rs12907966 | 15 | 78843051 | CHRNA5 | ENSG00000169684.9 | 1.089E-11 | 0 | -14811 | gtex_brain_putamen_basal |
| rs1504548 | 15 | 78843246 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -14616 | gtex_brain_putamen_basal |
| rs1979908 | 15 | 78843564 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -14298 | gtex_brain_putamen_basal |
| rs880395 | 15 | 78844356 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -13506 | gtex_brain_putamen_basal |
| rs905740 | 15 | 78844386 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -13476 | gtex_brain_putamen_basal |
| rs7164030 | 15 | 78844661 | CHRNA5 | ENSG00000169684.9 | 4.823E-12 | 0 | -13201 | gtex_brain_putamen_basal |
| rs4275821 | 15 | 78849541 | CHRNA5 | ENSG00000169684.9 | 4.235E-7 | 0 | -8321 | gtex_brain_putamen_basal |
| rs7173512 | 15 | 78849914 | CHRNA5 | ENSG00000169684.9 | 4.265E-7 | 0 | -7948 | gtex_brain_putamen_basal |
| rs3829787 | 15 | 78856266 | CHRNA5 | ENSG00000169684.9 | 7.122E-7 | 0 | -1596 | gtex_brain_putamen_basal |
| rs67624739 | 15 | 78857812 | CHRNA5 | ENSG00000169684.9 | 7.255E-9 | 0 | -50 | gtex_brain_putamen_basal |
| rs871058 | 15 | 78858491 | CHRNA5 | ENSG00000169684.9 | 1.616E-7 | 0 | 629 | gtex_brain_putamen_basal |
| rs57945453 | 15 | 78862845 | CHRNA5 | ENSG00000169684.9 | 5.913E-7 | 0 | 4983 | gtex_brain_putamen_basal |
| rs588765 | 15 | 78865425 | CHRNA5 | ENSG00000169684.9 | 9.003E-11 | 0 | 7563 | gtex_brain_putamen_basal |
| rs61012457 | 15 | 78865694 | CHRNA5 | ENSG00000169684.9 | 5.959E-7 | 0 | 7832 | gtex_brain_putamen_basal |
| rs6495306 | 15 | 78865893 | CHRNA5 | ENSG00000169684.9 | 8.992E-11 | 0 | 8031 | gtex_brain_putamen_basal |
| rs2456019 | 15 | 78868489 | CHRNA5 | ENSG00000169684.9 | 3.08E-7 | 0 | 10627 | gtex_brain_putamen_basal |
| rs601079 | 15 | 78869579 | CHRNA5 | ENSG00000169684.9 | 1.332E-9 | 0 | 11717 | gtex_brain_putamen_basal |
| rs495956 | 15 | 78869930 | CHRNA5 | ENSG00000169684.9 | 2.041E-6 | 0 | 12068 | gtex_brain_putamen_basal |
| rs495090 | 15 | 78870003 | CHRNA5 | ENSG00000169684.9 | 2.033E-6 | 0 | 12141 | gtex_brain_putamen_basal |
| rs471889 | 15 | 78870235 | CHRNA5 | ENSG00000169684.9 | 2.038E-6 | 0 | 12373 | gtex_brain_putamen_basal |
| rs680244 | 15 | 78871288 | CHRNA5 | ENSG00000169684.9 | 2.034E-9 | 0 | 13426 | gtex_brain_putamen_basal |
| rs10709956 | 15 | 78872834 | CHRNA5 | ENSG00000169684.9 | 2.692E-8 | 0 | 14972 | gtex_brain_putamen_basal |
| rs621849 | 15 | 78872861 | CHRNA5 | ENSG00000169684.9 | 1.332E-9 | 0 | 14999 | gtex_brain_putamen_basal |
| rs692780 | 15 | 78876505 | CHRNA5 | ENSG00000169684.9 | 2.987E-7 | 0 | 18643 | gtex_brain_putamen_basal |
| rs11637635 | 15 | 78877150 | CHRNA5 | ENSG00000169684.9 | 2.966E-7 | 0 | 19288 | gtex_brain_putamen_basal |
| rs481134 | 15 | 78877563 | CHRNA5 | ENSG00000169684.9 | 9.431E-11 | 0 | 19701 | gtex_brain_putamen_basal |
| rs5813927 | 15 | 78878100 | CHRNA5 | ENSG00000169684.9 | 9.922E-11 | 0 | 20238 | gtex_brain_putamen_basal |
| rs555018 | 15 | 78879242 | CHRNA5 | ENSG00000169684.9 | 2.062E-10 | 0 | 21380 | gtex_brain_putamen_basal |
| rs647041 | 15 | 78880481 | CHRNA5 | ENSG00000169684.9 | 5.374E-10 | 0 | 22619 | gtex_brain_putamen_basal |
| rs17408276 | 15 | 78881618 | CHRNA5 | ENSG00000169684.9 | 1.17E-6 | 0 | 23756 | gtex_brain_putamen_basal |
| rs584135 | 15 | 78883628 | CHRNA5 | ENSG00000169684.9 | 6.158E-7 | 0 | 25766 | gtex_brain_putamen_basal |
| rs514743 | 15 | 78884227 | CHRNA5 | ENSG00000169684.9 | 6.65E-7 | 0 | 26365 | gtex_brain_putamen_basal |
| rs615470 | 15 | 78885988 | CHRNA5 | ENSG00000169684.9 | 1.328E-6 | 0 | 28126 | gtex_brain_putamen_basal |
| rs660652 | 15 | 78887832 | CHRNA5 | ENSG00000169684.9 | 6.651E-7 | 0 | 29970 | gtex_brain_putamen_basal |
| rs472054 | 15 | 78887994 | CHRNA5 | ENSG00000169684.9 | 6.651E-7 | 0 | 30132 | gtex_brain_putamen_basal |
| rs398057851 | 15 | 78889782 | CHRNA5 | ENSG00000169684.9 | 1.909E-9 | 0 | 31920 | gtex_brain_putamen_basal |
| rs6495307 | 15 | 78890321 | CHRNA5 | ENSG00000169684.9 | 1.909E-9 | 0 | 32459 | gtex_brain_putamen_basal |
| rs12911602 | 15 | 78891449 | CHRNA5 | ENSG00000169684.9 | 1.909E-9 | 0 | 33587 | gtex_brain_putamen_basal |
| rs62010327 | 15 | 78892784 | CHRNA5 | ENSG00000169684.9 | 3.048E-7 | 0 | 34922 | gtex_brain_putamen_basal |
| rs12901300 | 15 | 78892952 | CHRNA5 | ENSG00000169684.9 | 1.909E-9 | 0 | 35090 | gtex_brain_putamen_basal |
| rs3743077 | 15 | 78894896 | CHRNA5 | ENSG00000169684.9 | 1.454E-9 | 0 | 37034 | gtex_brain_putamen_basal |
| rs62010328 | 15 | 78894971 | CHRNA5 | ENSG00000169684.9 | 3.006E-7 | 0 | 37109 | gtex_brain_putamen_basal |
| rs75104798 | 15 | 78897865 | CHRNA5 | ENSG00000169684.9 | 1.467E-6 | 0 | 40003 | gtex_brain_putamen_basal |
| rs7182583 | 15 | 78899210 | CHRNA5 | ENSG00000169684.9 | 1.329E-6 | 0 | 41348 | gtex_brain_putamen_basal |
| rs111725959 | 15 | 78899346 | CHRNA5 | ENSG00000169684.9 | 1.135E-6 | 0 | 41484 | gtex_brain_putamen_basal |
| rs7495518 | 15 | 78900574 | CHRNA5 | ENSG00000169684.9 | 3.029E-7 | 0 | 42712 | gtex_brain_putamen_basal |
| rs139978901 | 15 | 78902026 | CHRNA5 | ENSG00000169684.9 | 6.939E-8 | 0 | 44164 | gtex_brain_putamen_basal |
| rs183822442 | 15 | 78902775 | CHRNA5 | ENSG00000169684.9 | 5.872E-9 | 0 | 44913 | gtex_brain_putamen_basal |
| rs190259891 | 15 | 78902906 | CHRNA5 | ENSG00000169684.9 | 5.66E-9 | 0 | 45044 | gtex_brain_putamen_basal |
| rs77403874 | 15 | 78903165 | CHRNA5 | ENSG00000169684.9 | 1.225E-8 | 0 | 45303 | gtex_brain_putamen_basal |
| rs200722258 | 15 | 78906118 | CHRNA5 | ENSG00000169684.9 | 2.335E-7 | 0 | 48256 | gtex_brain_putamen_basal |
| rs9646187 | 15 | 78906128 | CHRNA5 | ENSG00000169684.9 | 9.88E-7 | 0 | 48266 | gtex_brain_putamen_basal |
| rs2869546 | 15 | 78907345 | CHRNA5 | ENSG00000169684.9 | 1.463E-6 | 0 | 49483 | gtex_brain_putamen_basal |
| rs3743075 | 15 | 78909452 | CHRNA5 | ENSG00000169684.9 | 3.947E-7 | 0 | 51590 | gtex_brain_putamen_basal |
| rs3743074 | 15 | 78909480 | CHRNA5 | ENSG00000169684.9 | 2.938E-6 | 0 | 51618 | gtex_brain_putamen_basal |
| rs3743073 | 15 | 78909539 | CHRNA5 | ENSG00000169684.9 | 7.585E-7 | 0 | 51677 | gtex_brain_putamen_basal |
| rs2067808 | 15 | 78911780 | CHRNA5 | ENSG00000169684.9 | 1.117E-6 | 0 | 53918 | gtex_brain_putamen_basal |
| rs1878399 | 15 | 78912003 | CHRNA5 | ENSG00000169684.9 | 5.126E-10 | 0 | 54141 | gtex_brain_putamen_basal |
| rs201576627 | 15 | 78912201 | CHRNA5 | ENSG00000169684.9 | 1.737E-8 | 0 | 54339 | gtex_brain_putamen_basal |
| rs4366683 | 15 | 78912203 | CHRNA5 | ENSG00000169684.9 | 1.674E-8 | 0 | 54341 | gtex_brain_putamen_basal |
| rs386419558 | 15 | 78912203 | CHRNA5 | ENSG00000169684.9 | 1.32E-8 | 0 | 54341 | gtex_brain_putamen_basal |
| rs4352017 | 15 | 78912204 | CHRNA5 | ENSG00000169684.9 | 5.411E-9 | 0 | 54342 | gtex_brain_putamen_basal |
| rs8025188 | 15 | 78912278 | CHRNA5 | ENSG00000169684.9 | 1.51E-8 | 0 | 54416 | gtex_brain_putamen_basal |
| rs7178270 | 15 | 78921077 | CHRNA5 | ENSG00000169684.9 | 2.13E-9 | 0 | 63215 | gtex_brain_putamen_basal |
| rs11635249 | 15 | 78924604 | CHRNA5 | ENSG00000169684.9 | 1.026E-6 | 0 | 66742 | gtex_brain_putamen_basal |
| rs11636753 | 15 | 78928946 | CHRNA5 | ENSG00000169684.9 | 8.992E-7 | 0 | 71084 | gtex_brain_putamen_basal |
| rs57728226 | 15 | 78929350 | CHRNA5 | ENSG00000169684.9 | 2.013E-8 | 0 | 71488 | gtex_brain_putamen_basal |
| rs36045869 | 15 | 78929498 | CHRNA5 | ENSG00000169684.9 | 2.013E-8 | 0 | 71636 | gtex_brain_putamen_basal |
| rs11637890 | 15 | 78935419 | CHRNA5 | ENSG00000169684.9 | 1.55E-8 | 0 | 77557 | gtex_brain_putamen_basal |
| rs11633223 | 15 | 78935476 | CHRNA5 | ENSG00000169684.9 | 1.55E-8 | 0 | 77614 | gtex_brain_putamen_basal |
| rs28444683 | 15 | 78984507 | CHRNA5 | ENSG00000169684.9 | 2.873E-6 | 0 | 126645 | gtex_brain_putamen_basal |
| rs11072802 | 15 | 79067857 | CHRNA5 | ENSG00000169684.9 | 4.719E-7 | 0 | 209995 | gtex_brain_putamen_basal |
| rs78657732 | 15 | 79067862 | CHRNA5 | ENSG00000169684.9 | 3.465E-7 | 0 | 210000 | gtex_brain_putamen_basal |
| rs75716787 | 15 | 79067864 | CHRNA5 | ENSG00000169684.9 | 3.818E-7 | 0 | 210002 | gtex_brain_putamen_basal |
| rs78632183 | 15 | 79067866 | CHRNA5 | ENSG00000169684.9 | 2.527E-7 | 0 | 210004 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0015464 | acetylcholine receptor activity | IDA | Neurotransmitter (GO term level: 6) | 1542648 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | NAS | 1542648 | |
| GO:0005216 | ion channel activity | IEA | - | |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 9009220 |
| GO:0007165 | signal transduction | NAS | 9009220 | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0035095 | behavioral response to nicotine | IMP | 18227835 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | IC | Neurotransmitter (GO term level: 9) | 1542648 |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS | 16 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | 13 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | 12 | 10 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 1 DN | 169 | 102 | All SZGR 2.0 genes in this pathway |
| RAMASWAMY METASTASIS DN | 61 | 47 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 24HR UP | 148 | 96 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | 41 | 26 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 | 142 | 103 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| STEIN ESR1 TARGETS | 85 | 55 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 | 210 | 148 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| SCHMIDT POR TARGETS IN LIMB BUD DN | 8 | 7 | All SZGR 2.0 genes in this pathway |