SZGR2

Summary ?

GeneID	1656
Symbol	DDX6
Synonyms	HLR2\|P54\|RCK
Description	DEAD-box helicase 6
Reference	MIM:600326\|HGNC:HGNC:2747\|Ensembl:ENSG00000110367\|HPRD:02638\|
Gene type	protein-coding
Map location	11q23.3
Pascal p-value	0.016
Fetal beta	0.666
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
CV:PheWAS	Phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	0
GSMA_I	Genome scan meta-analysis	Psr: 0.006

Section I. Genetics and epigenetics annotation

CV:PheWAS

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs17107307	chr1	53039245	DDX6	1656	0	trans
rs7533675	chr1	64861845	DDX6	1656	0.17	trans
rs11209636	chr1	71024708	DDX6	1656	1.979E-4	trans
rs17101052	chr1	78370990	DDX6	1656	0.02	trans
rs4001776	chr1	81605073	DDX6	1656	0.13	trans
rs17305183	chr1	94423976	DDX6	1656	0.01	trans
rs920513	chr1	120272605	DDX6	1656	0.17	trans
rs2241110	chr1	156172486	DDX6	1656	0.07	trans
snp_a-4263591		0	DDX6	1656	0.06	trans
rs16850728	chr1	177074044	DDX6	1656	0.17	trans
rs12078096	chr1	200130068	DDX6	1656	0.02	trans
rs475416	chr1	201469606	DDX6	1656	0.01	trans
rs4915530	chr1	201489639	DDX6	1656	0.02	trans
rs17047227	chr1	218198394	DDX6	1656	0.17	trans
rs12060661	chr1	218238494	DDX6	1656	0.01	trans
rs17017737	chr2	3658723	DDX6	1656	0.15	trans
rs2712089	chr2	24080273	DDX6	1656	0.17	trans
rs11896752	chr2	70980941	DDX6	1656	0.17	trans
rs4402787	chr2	106331504	DDX6	1656	0.13	trans
rs264663	chr2	159910205	DDX6	1656	0.1	trans
rs7584986	chr2	184111432	DDX6	1656	0.01	trans
rs13418573	chr2	205418512	DDX6	1656	7.087E-4	trans
rs4408717	chr2	228232445	DDX6	1656	0.03	trans
rs17031896	chr3	3509504	DDX6	1656	0.15	trans
rs6803351	chr3	17336986	DDX6	1656	0	trans
rs11916205	chr3	17392363	DDX6	1656	0	trans
rs17043486	chr3	17399005	DDX6	1656	0	trans
rs17029249	chr3	17416384	DDX6	1656	0	trans
rs10510474	chr3	17417495	DDX6	1656	0	trans
rs17043623	chr3	17478890	DDX6	1656	0	trans
rs11128830	chr3	17481727	DDX6	1656	0	trans
rs17044097	chr3	17889750	DDX6	1656	0	trans
rs17044102	chr3	17889838	DDX6	1656	0.1	trans
rs1155107	chr3	26843376	DDX6	1656	0.17	trans
rs17029291	chr3	32402138	DDX6	1656	0.03	trans
rs4627772		0	DDX6	1656	0.02	trans
rs17079580	chr3	47363841	DDX6	1656	0.02	trans
rs2611410	chr3	60399847	DDX6	1656	0.11	trans
rs1862304	chr3	64712943	DDX6	1656	0	trans
rs7612427	chr3	103006644	DDX6	1656	0.02	trans
rs1553189	chr3	112939422	DDX6	1656	0	trans
rs16862729	chr3	187652723	DDX6	1656	6.177E-5	trans
rs4461532	chr4	37679271	DDX6	1656	0.12	trans
rs17538033	chr4	46876948	DDX6	1656	0.08	trans
rs6836259	chr4	57173074	DDX6	1656	0	trans
rs4386669	chr4	69796837	DDX6	1656	0.12	trans
rs12646252		0	DDX6	1656	0.15	trans
snp_a-1815771		0	DDX6	1656	0.17	trans
rs1039050	chr4	81339909	DDX6	1656	0.19	trans
rs7691290	chr4	81340799	DDX6	1656	0.19	trans
rs6534931	chr4	81358504	DDX6	1656	0.19	trans
rs12645692	chr4	130887472	DDX6	1656	0.01	trans
rs4392549	chr4	158263581	DDX6	1656	0.05	trans
rs7672900	chr4	170299204	DDX6	1656	0.19	trans
rs17065363	chr4	178775387	DDX6	1656	0.17	trans
rs17065376	chr4	178778168	DDX6	1656	0.19	trans
rs4632699	chr4	182350405	DDX6	1656	0.13	trans
rs17707924	chr5	16877366	DDX6	1656	0.07	trans
rs7736397	chr5	21908405	DDX6	1656	0.05	trans
rs7729965	chr5	21910425	DDX6	1656	0.01	trans
rs16901958	chr5	44776555	DDX6	1656	0.01	trans
rs750544	chr5	51749054	DDX6	1656	0.03	trans
rs16886054	chr5	55986056	DDX6	1656	0.13	trans
rs16886056	chr5	55986175	DDX6	1656	0.13	trans
rs6878189	chr5	55987195	DDX6	1656	0.13	trans
rs6892240	chr5	55987229	DDX6	1656	0.13	trans
rs6882530	chr5	55987416	DDX6	1656	0.02	trans
rs6882818	chr5	55987580	DDX6	1656	0.12	trans
rs16872194	chr5	73975829	DDX6	1656	0.02	trans
rs749169	chr5	77161057	DDX6	1656	0	trans
rs17085165	chr5	95169502	DDX6	1656	0	trans
rs2605198	chr5	114749903	DDX6	1656	0.01	trans
rs12654569	chr5	125972281	DDX6	1656	0.02	trans
rs3812061	chr5	126213763	DDX6	1656	0.11	trans
rs17165234	chr5	126403634	DDX6	1656	1.072E-7	trans
rs12655006	chr5	126407601	DDX6	1656	0.17	trans
rs17067019	chr5	165922574	DDX6	1656	0.15	trans
rs6880907	chr5	180002432	DDX6	1656	0.17	trans
rs6940323	chr6	37456563	DDX6	1656	0.03	trans
rs12523722	chr6	40666907	DDX6	1656	0.14	trans
rs9294325	chr6	85767265	DDX6	1656	0.01	trans
rs16870406	chr6	93618926	DDX6	1656	0.02	trans
rs9385758	chr6	136729593	DDX6	1656	0.01	trans
rs2397	chr7	1004522	DDX6	1656	0.18	trans
rs17141097	chr7	19338527	DDX6	1656	0.18	trans
rs3025144	chr7	24273158	DDX6	1656	0.06	trans
rs10486575	chr7	28107379	DDX6	1656	0.02	trans
rs11489759	chr7	56393851	DDX6	1656	0.01	trans
rs3779536	chr7	127233976	DDX6	1656	0.01	trans
rs6467703	chr7	136971907	DDX6	1656	0.15	trans
rs6464150	chr7	151305583	DDX6	1656	0.01	trans
rs11137050	chr8	6527010	DDX6	1656	0.02	trans
rs4615570	chr8	13349013	DDX6	1656	0.02	trans
rs16926030	chr8	61251997	DDX6	1656	0.12	trans
rs16899786	chr8	125599624	DDX6	1656	0.16	trans
rs16925800	chr9	10315192	DDX6	1656	0	trans
rs10961079	chr9	13478522	DDX6	1656	0.01	trans
rs1041529	chr9	15549730	DDX6	1656	0.13	trans
rs10739219	chr9	108938328	DDX6	1656	0.1	trans
rs16933774	chr9	119400396	DDX6	1656	0.02	trans
rs803927	chr9	119403610	DDX6	1656	0	trans
rs10118266	chr9	119509275	DDX6	1656	0.13	trans
rs9409946	chr9	138293640	DDX6	1656	0.07	trans
rs10745380	chr9	138972860	DDX6	1656	0.07	trans
rs16924742	chr10	24716193	DDX6	1656	0.01	trans
rs17177717	chr10	50764502	DDX6	1656	0	trans
rs10857512	chr10	50790189	DDX6	1656	0.01	trans
rs7915036	chr10	64642198	DDX6	1656	0.08	trans
rs16930573	chr10	75167645	DDX6	1656	0.01	trans
rs11595743	chr10	78142856	DDX6	1656	0.09	trans
rs17099339	chr10	83832303	DDX6	1656	9.007E-4	trans
rs11200847	chr10	85855451	DDX6	1656	0	trans
snp_a-2055321		0	DDX6	1656	0.04	trans
rs7076439	chr10	93286841	DDX6	1656	0.03	trans
rs11186601	chr10	93287199	DDX6	1656	0.07	trans
rs1530180	chr11	12896635	DDX6	1656	0.09	trans
rs2132190	chr11	43393698	DDX6	1656	0.14	trans
rs10838567	chr11	46136342	DDX6	1656	0.05	trans
rs17136959	chr11	78373036	DDX6	1656	0	trans
rs4944213	chr11	78395188	DDX6	1656	0	trans
rs11237884	chr11	79233102	DDX6	1656	2.57E-5	trans
rs11821336	chr11	82626911	DDX6	1656	0.08	trans
rs10219424	chr11	124565387	DDX6	1656	0.11	trans
rs832723	chr12	47613283	DDX6	1656	0.13	trans
rs7309749	chr12	69531501	DDX6	1656	0.01	trans
rs17042851	chr12	77469962	DDX6	1656	7.236E-5	trans
rs1566556	chr12	101918977	DDX6	1656	0.01	trans
rs17085657	chr13	28041054	DDX6	1656	0.14	trans
rs17054422	chr13	37317864	DDX6	1656	6.465E-7	trans
rs11842952	chr13	47804997	DDX6	1656	0.04	trans
rs2804085	chr13	48955200	DDX6	1656	0.02	trans
rs9332066	chr13	49064965	DDX6	1656	0.02	trans
rs11842662	chr13	49160926	DDX6	1656	0.02	trans
rs17071960	chr13	49164194	DDX6	1656	0.11	trans
rs9285167		0	DDX6	1656	0.09	trans
rs7338141	chr13	49172775	DDX6	1656	0	trans
rs11619375	chr13	96843552	DDX6	1656	0.03	trans
rs8001216	chr13	98677727	DDX6	1656	0.05	trans
rs9584828	chr13	99040306	DDX6	1656	0.05	trans
rs1610001	chr13	100484419	DDX6	1656	5.372E-4	trans
rs17691399	chr13	103326901	DDX6	1656	0.11	trans
rs1324669	chr13	107872446	DDX6	1656	2.798E-26	trans
rs7332984	chr13	108328677	DDX6	1656	0.17	trans
rs6492262	chr13	111000751	DDX6	1656	0.04	trans
snp_a-2212061		0	DDX6	1656	3.266E-8	trans
rs808224	chr14	58397735	DDX6	1656	0.09	trans
rs768973	chr14	66507075	DDX6	1656	0.13	trans
rs17105029	chr14	77399228	DDX6	1656	0.15	trans
rs17108189	chr14	79211580	DDX6	1656	0.19	trans
rs17124250	chr14	88668499	DDX6	1656	0.15	trans
rs10131611	chr14	88768614	DDX6	1656	0.07	trans
rs2430355	chr14	92355946	DDX6	1656	0	trans
rs1743505	chr14	96143407	DDX6	1656	0.13	trans
rs2123148	chr15	45018734	DDX6	1656	0.07	trans
rs12591795	chr15	53565626	DDX6	1656	0.03	trans
rs272763	chr15	53641118	DDX6	1656	5.203E-5	trans
rs782949	chr15	61344246	DDX6	1656	3.823E-4	trans
rs1559448	chr16	17530587	DDX6	1656	0.01	trans
rs3924428	chr16	25934820	DDX6	1656	0.18	trans
rs17175143	chr17	3348603	DDX6	1656	0.01	trans
rs1630431	chr17	45181301	DDX6	1656	0.15	trans
rs11570451	chr17	45266162	DDX6	1656	0.18	trans
rs16958358	chr17	55502410	DDX6	1656	0.19	trans
rs16961075	chr18	28593016	DDX6	1656	0.01	trans
rs9949772	chr18	31042632	DDX6	1656	0.07	trans
rs621576	chr18	32570204	DDX6	1656	0.19	trans
rs17746713	chr18	34031439	DDX6	1656	0.02	trans
rs2112060	chr18	62038368	DDX6	1656	0.1	trans
rs676435	chr18	66031699	DDX6	1656	0.04	trans
rs2469009	chr18	70713334	DDX6	1656	0	trans
rs17088584	chr18	71610684	DDX6	1656	0.03	trans
rs733524	chr20	11006630	DDX6	1656	0.05	trans
rs17124476	chr20	31833763	DDX6	1656	0	trans
rs16987990	chr20	41966000	DDX6	1656	0.08	trans
rs743152	chr20	42569910	DDX6	1656	0	trans
rs6130486	chr20	42573591	DDX6	1656	0	trans
rs6098023	chr20	53113740	DDX6	1656	0.07	trans
rs17793479	chr20	59328916	DDX6	1656	0.06	trans
rs9015	chr21	42549006	DDX6	1656	0.02	trans
rs2838392	chr21	45231958	DDX6	1656	1.425E-4	trans
rs3788466	chr22	33021337	DDX6	1656	0.12	trans
rs7511209	chr22	33030025	DDX6	1656	0.12	trans
rs16996446	chr22	36560293	DDX6	1656	0	trans
rs7290732	chr22	46691902	DDX6	1656	0.09	trans
rs130834	chr22	48815310	DDX6	1656	0.01	trans
rs16985247	chrX	8865786	DDX6	1656	0.06	trans
rs17145698	chrX	40218345	DDX6	1656	9.687E-12	trans
rs17174152	chrX	70403143	DDX6	1656	0.12	trans
rs17328938	chrX	99519447	DDX6	1656	2.26E-13	trans
rs1335267	chrX	99570223	DDX6	1656	2.26E-13	trans
rs7879372	chrX	115479764	DDX6	1656	0.01	trans
rs12007645	chrX	115480438	DDX6	1656	0.01	trans
rs7065248	chrX	115510530	DDX6	1656	5.657E-5	trans
rs7880810	chrX	115521304	DDX6	1656	0.01	trans
rs2284128	chrX	133096371	DDX6	1656	0.04	trans
rs17002551	chrX	139972731	DDX6	1656	0.01	trans
rs16996714	chrX	149897486	DDX6	1656	0.1	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003723	RNA binding	IEA		-
GO:0003724	RNA helicase activity	TAS		1579499
GO:0005515	protein binding	IPI		17392519
GO:0005524	ATP binding	IEA		-
GO:0016787	hydrolase activity	IEA		-
GO:0008026	ATP-dependent helicase activity	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-
GO:0010494	stress granule	IDA		17392519

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RNA DEGRADATION	59	37	All SZGR 2.0 genes in this pathway
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	10	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP	150	93	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN	137	97	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 23	24	13	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP	35	25	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP	156	92	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0	76	54	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1	68	50	All SZGR 2.0 genes in this pathway
BAUS TFF2 TARGETS DN	11	7	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES	90	54	All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT2 TARGETS	58	35	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN	106	77	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	456	462	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	455	462	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	455	462	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	204	210	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	204	210	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-129-5p	1912	1919	1A,m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	1912	1919	1A,m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	228	235	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
				hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152	202	208	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-19	200	206	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	200	206	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-192/215	1873	1880	1A,m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	1873	1880	1A,m8	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-203.1	386	392	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-205	1060	1066	m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-22	1102	1108	1A	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-221/222	2160	2166	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	2160	2166	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-30-3p	164	170	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	164	170	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-376	105	111	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	105	111	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-381	980	987	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-450	1912	1918	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DDX6