Gene Page: DPP4

Summary
GeneID  1803
Symbol  DPP4
Synonyms  ADABP|ADCP2|CD26|DPPIV|TP103
Description  dipeptidyl-peptidase 4
See related  HGNC:3009|MIM:102720|Ensembl:ENSG00000197635|HPRD:02187|
Locus tag  -
Gene type  protein-coding
Map location  2q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DMPK0.600.69
AC004410.10.570.67
SLC12A90.570.67
PRX0.560.66
AC006028.30.560.63
CCDC370.540.48
ZNF2960.530.65
AMIGO30.530.68
PCSK40.530.58
AP006284.20.530.53
Top 10 negatively co-expressed genes
KBTBD3-0.43-0.58
UGP2-0.41-0.46
ATP6V1E1-0.40-0.40
FAM162A-0.39-0.49
HIGD1A-0.39-0.49
CHN1-0.39-0.39
MDH1-0.38-0.39
C12orf29-0.38-0.45
TMEM70-0.38-0.41
C1orf43-0.38-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004177aminopeptidase activityIEA-
GO:0005515protein bindingIPI7594462 |14684150 
GO:0008239dipeptidyl-peptidase activityIDA14684150 
GO:0008233peptidase activityIEA-
GO:0042803protein homodimerization activityIPI14684150 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001666response to hypoxiaIDA16670267 
GO:0006508proteolysisIEA-
GO:0042110T cell activationIDA7594462 
GO:0033632regulation of cell-cell adhesion mediated by integrinIDA11772392 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA7594462 |11772392 
GO:0005886plasma membraneIDA16670267 
GO:0046581intercellular canaliculusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPAMD8FLJ42058 | FLJ90618 | K-CAP | KIAA1283 | VIPC3 and PZP-like, alpha-2-macroglobulin domain containing 8-HPRD11696365 
GRPBN | GRP-10 | preproGRP | proGRPgastrin-releasing peptide-HPRD11696365 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD1680916 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP 148All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN 14383All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
CAVARD_LIVER_CANCER_MALIGNANT_VS_BENIGN 3219All SZGR genes in this pathway
MURATA_VIRULENCE_OF_H_PILORI 2416All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
TRAYNOR_RETT_SYNDROM_UP 4533All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_DN 4833All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_UP 3525All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP 3826All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_UP 4729All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
VALK_AML_CLUSTER_1 2819All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_UP 129All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
KOHOUTEK_CCNT2_TARGETS 5835All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1406026091A,m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-148/1525855911Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1535775831Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-2058488541Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-22770776m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-296866921Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-3785645701Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-4485765831A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-96256311Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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