SZGR2

Summary ?

GeneID	1952
Symbol	CELSR2
Synonyms	ADGRC2\|CDHF10\|EGFL2\|Flamingo1\|MEGF3
Description	cadherin EGF LAG seven-pass G-type receptor 2
Reference	MIM:604265\|HGNC:HGNC:3231\|Ensembl:ENSG00000143126\|HPRD:05040\|Vega:OTTHUMG00000012003
Gene type	protein-coding
Map location	1p21
Pascal p-value	0.346
Sherlock p-value	0.25
TADA p-value	0.034
Fetal beta	-0.239
eGene	Meta
Support	CompositeSet Darnell FMRP targets Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Gulsuner_2013	Whole Exome Sequencing analysis	155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
CELSR2	chr1	109793969	C	G	NM_001408	p.423A>G	missense			Schizophrenia	DNM:Gulsuner_2013
CELSR2	chr1	109793295	C	G	NM_001408	.	silent			Schizophrenia	DNM:Gulsuner_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
COPS2	0.92	0.89
C11orf58	0.91	0.91
YWHAE	0.91	0.88
TAF7	0.91	0.89
TIPRL	0.90	0.90
CUL2	0.90	0.90
PTGES3	0.90	0.89
CNOT7	0.90	0.90
PSMD14	0.90	0.88
SMNDC1	0.90	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.69	-0.71
AF347015.8	-0.68	-0.72
AF347015.2	-0.68	-0.73
AF347015.31	-0.67	-0.71
AF347015.15	-0.67	-0.72
MT-CYB	-0.67	-0.70
AF347015.33	-0.66	-0.69
AF347015.27	-0.66	-0.70
AF347015.26	-0.66	-0.70
AF347015.21	-0.62	-0.63

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0004930	G-protein coupled receptor activity	IEA		-
GO:0004930	G-protein coupled receptor activity	NAS		10907856
GO:0005509	calcium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007218	neuropeptide signaling pathway	IEA	Neurotransmitter (GO term level: 8)	-
GO:0048813	dendrite morphogenesis	ISS	neurite, dendrite (GO term level: 12)	-
GO:0007156	homophilic cell adhesion	IEA		-
GO:0016055	Wnt receptor signaling pathway	ISS		-
GO:0007165	signal transduction	IEA		-
GO:0007275	multicellular organismal development	IEA		-
GO:0022407	regulation of cell-cell adhesion	ISS		-
GO:0021999	neural plate anterioposterior pattern formation	ISS		-
GO:0032583	regulation of gene-specific transcription	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	ISS		-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	NAS		10907856
GO:0005886	plasma membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN	84	53	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN	29	19	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP	21	15	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP	140	85	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6	39	27	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE UP	66	44	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN	41	26	All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN	45	31	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53	109	63	All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP	104	57	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP	10	7	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP	857	456	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP	211	131	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	663	670	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	663	670	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-125/351	311	317	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	311	317	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-17-5p/20/93.mr/106/519.d	216	222	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-193	831	837	m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	831	837	m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-214	1010	1016	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-328	232	238	1A	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-431	245	251	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-485-5p	393	399	m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-9	361	367	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	184	190	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CELSR2