Gene Page: A2M

Summary ?
GeneID2
SymbolA2M
SynonymsA2MD|CPAMD5|FWP007|S863-7
Descriptionalpha-2-macroglobulin
ReferenceMIM:103950|HGNC:HGNC:7|Ensembl:ENSG00000175899|HPRD:00072|Vega:OTTHUMG00000150267
Gene typeprotein-coding
Map location12p13.31
Pascal p-value0.529
Sherlock p-value0.668
Fetal beta-1.656
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 4.179 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg27166707129227209A2M7.16E-50.4040.025DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1999514chr1384147878A2M20.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NDUFB70.880.47
LSMD10.870.51
C17orf900.850.61
ZNF5930.840.58
C7orf590.830.58
C19orf600.830.70
HBQ10.830.62
C9orf160.830.55
PSMB100.820.50
NDUFA20.820.49
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CANX-0.39-0.37
AC005332.1-0.38-0.30
ARHGAP5-0.38-0.40
DYNC1LI2-0.37-0.30
ZNHIT6-0.37-0.34
KIAA1033-0.37-0.37
RAB5A-0.37-0.32
XPOT-0.36-0.29
CD2AP-0.36-0.36
YES1-0.36-0.43

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0017114wide-spectrum protease inhibitor activityIEA-
GO:0019959interleukin-8 bindingIPI10880251 
GO:0019966interleukin-1 bindingIDA9714181 
GO:0019899enzyme bindingIPI11435418 
GO:0043120tumor necrosis factor bindingIDA9714181 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051260protein homooligomerizationNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP59727 
GO:0005576extracellular regionNAS14718574 
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0031093platelet alpha granule lumenEXP59727 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAM19FKSG34 | MADDAM | MLTNBADAM metallopeptidase domain 19 (meltrin beta)-HPRD11162584 
ADAMTS1C3-C5 | KIAA1346 | METH1ADAM metallopeptidase with thrombospondin type 1 motif, 1-HPRD,BioGRID10373500 
AMBPEDC1 | HCP | HI30 | IATIL | ITI | ITIL | ITILC | UTIalpha-1-microglobulin/bikunin precursor-HPRD,BioGRID1697852 |7519849 
|7533162 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD,BioGRID9831625 
B2M-beta-2-microglobulin-HPRD,BioGRID10731476 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)Reconstituted ComplexBioGRID8662763 
CTSBAPPS | CPSBcathepsin B-HPRD2476070 
ELA1-elastase 1, pancreatic-HPRD6153632 |6191979 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID12194978 
IL10CSIF | IL-10 | IL10A | MGC126450 | MGC126451 | TGIFinterleukin 10-HPRD,BioGRID10714547 
IL1BIL-1 | IL1-BETA | IL1F2interleukin 1, beta-HPRD9714181 
IL4BCGF-1 | BCGF1 | BSF1 | IL-4 | MGC79402interleukin 4Reconstituted ComplexBioGRID10714547 
KLK13DKFZp586J1923 | KLK-L4 | KLKL4kallikrein-related peptidase 13Reconstituted ComplexBioGRID14687906 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3-HPRD8583572 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3Affinity Capture-WesternBioGRID1702714 
LCAT-lecithin-cholesterol acyltransferase-HPRD,BioGRID11435418 
LEPFLJ94114 | OB | OBSleptin-HPRD,BioGRID9724081 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID10652313 
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Reconstituted ComplexBioGRID9344465 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)-HPRD,BioGRID10681572 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial protein-HPRD,BioGRID11023837 
PDGFBFLJ12858 | PDGF2 | SIS | SSV | c-sisplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)-HPRD10681572 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)An unspecified isoform of STAT3 binds APRE.BIND15950906 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 4740All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 11381All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME HDL MEDIATED LIPID TRANSPORT 1512All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 3222All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY 1712All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 4637All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 2824All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205140All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA UP 1611All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 3320All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS DN 3725All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 2518All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 DN 1913All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 UP 1510All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN 2821All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 14780All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL CIS 76All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 8769All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS DN 95All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 11484All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN 3021All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 2622All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 4127All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 6445All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP 7848All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 5334All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 2015All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 6647All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 17496All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 10457All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 3220All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153107All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS 6235All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway