Gene Page: ALDH1A1

Summary ?
GeneID216
SymbolALDH1A1
SynonymsALDC|ALDH-E1|ALDH1|ALDH11|HEL-9|HEL-S-53e|HEL12|PUMB1|RALDH1
Descriptionaldehyde dehydrogenase 1 family member A1
ReferenceMIM:100640|HGNC:HGNC:402|Ensembl:ENSG00000165092|HPRD:00001|Vega:OTTHUMG00000020019
Gene typeprotein-coding
Map location9q21.13
Pascal p-value0.332
Sherlock p-value0.501
Fetal beta-3.479
eGeneMyers' cis & trans
SupportG2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1020772chr976532511ALDH1A12160.09cis
rs16829545chr2151977407ALDH1A12160.18trans
rs7584986chr2184111432ALDH1A12160.18trans
rs2393316chr1059333070ALDH1A12160.17trans
rs16955618chr1529937543ALDH1A12168.55E-4trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TRIM270.880.89
MOCS30.870.89
LDOC1L0.870.89
EHD10.870.83
PPAPDC20.870.90
UBQLN40.870.87
ZNF6890.870.88
CAPN10.870.91
FAM40A0.870.91
UBA10.870.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.71-0.82
MT-CO2-0.70-0.83
AF347015.27-0.69-0.80
AF347015.33-0.68-0.78
MT-CYB-0.68-0.80
AF347015.8-0.68-0.82
FXYD1-0.67-0.78
AF347015.15-0.65-0.78
HLA-F-0.65-0.70
AF347015.21-0.65-0.84

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001758retinal dehydrogenase activityIEA-
GO:0004029aldehyde dehydrogenase (NAD) activityEXP224930 
GO:0004029aldehyde dehydrogenase (NAD) activityTAS1709013 
GO:0005099Ras GTPase activator activityTAS1709013 
GO:0005497androgen bindingTAS1709013 
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006081cellular aldehyde metabolic processTAS1709013 
GO:0008152metabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP224930 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS2987944 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RETINOL METABOLISM 6437All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
REACTOME ETHANOL OXIDATION 109All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP 159All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 5534All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
MOROSETTI FACIOSCAPULOHUMERAL MUSCULAR DISTROPHY DN 126All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 6647All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 8557All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS D DN 96All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA FOREVER UP 1913All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 6244All SZGR 2.0 genes in this pathway
MAHADEVAN IMATINIB RESISTANCE UP 2315All SZGR 2.0 genes in this pathway
ABDULRAHMAN KIDNEY CANCER VHL DN 149All SZGR 2.0 genes in this pathway
LI LUNG CANCER 4130All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
MAINA VHL TARGETS UP 106All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS DN 87All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR DN 4634All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE DN 136All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX5 UP 117All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 8944All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS UP 3525All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 9057All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
SMITH LIVER CANCER 4527All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 6844All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 6442All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 7856All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 13187All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182119All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 4127All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 6445All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS DN 3818All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148102All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 4533All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260174All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP 11271All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 4026All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 13899All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET DN 65All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 16280All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169105All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway