Gene Page: GFRA1

Summary
GeneID  2674
Symbol  GFRA1
Synonyms  GDNFR|GDNFRA|GFR-ALPHA-1|MGC23045|RET1L|RETL1|TRNR1
Description  GDNF family receptor alpha 1
See related  HGNC:4243|MIM:601496|Ensembl:ENSG00000151892|HPRD:03291|
Locus tag  -
Gene type  protein-coding
Map location  10q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ABAT0.670.69
KIAA10240.650.68
LRRTM30.640.71
SLITRK30.630.69
SPATS2L0.630.61
GUCY1A30.630.64
LUZP20.630.67
ALDH5A10.630.70
RPAP30.630.65
PDE4B0.630.61
Top 10 negatively co-expressed genes
AF347015.21-0.38-0.36
AC098691.2-0.36-0.41
MT-CO2-0.35-0.36
FXYD1-0.35-0.32
HIGD1B-0.35-0.36
S100A13-0.34-0.32
MYL3-0.33-0.31
AF347015.31-0.33-0.35
CSAG1-0.33-0.31
C1orf54-0.32-0.35
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016167glial cell line-derived neurotrophic factor receptor activityTASneurotrophic, Glial (GO term level: 7)10829012 
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)9545641 
GO:0004872receptor activityNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionNAS8674117 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0031225anchored to membraneIEA-
GO:0019898extrinsic to membraneNAS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GDNFATF1 | ATF2 | HFB1-GDNFglial cell derived neurotrophic factor-HPRD8674117 |9482105 
Reconstituted ComplexBioGRID9407096 |10829012 
NRTNNTNneurturin-HPRD,BioGRID9407096 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogene-HPRD9740802 |10829012 
Reconstituted ComplexBioGRID9192898 |10829012 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM1_INTERACTIONS 3927All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4 11066All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-38167741A,m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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