Gene Page: GHSR

Summary ?
GeneID2693
SymbolGHSR
SynonymsGHDP
Descriptiongrowth hormone secretagogue receptor
ReferenceMIM:601898|HGNC:HGNC:4267|Ensembl:ENSG00000121853|HPRD:03541|Vega:OTTHUMG00000156946
Gene typeprotein-coding
Map location3q26.31
Pascal p-value0.627
Fetal beta0.173
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705GHSR26930.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CABP10.820.68
CCDC64B0.760.65
GLS20.750.68
ANXA110.740.73
ABTB10.740.68
TECR0.740.62
ISCU0.740.66
ACTR1B0.740.60
PRSS160.740.64
P2RX60.730.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PKN1-0.44-0.51
PDE9A-0.42-0.53
NKIRAS2-0.42-0.36
SH2B2-0.41-0.54
TUBB2B-0.40-0.54
SH3BP2-0.40-0.52
KIAA1949-0.40-0.48
FADS2-0.39-0.41
MARCKSL1-0.39-0.44
YBX1-0.39-0.48

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001616growth hormone secretagogue receptor activityIDA8688086 
GO:0004872receptor activityIEA-
GO:0016520growth hormone-releasing hormone receptor activityIDA8688086 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051963regulation of synaptogenesisIEASynap (GO term level: 9)-
GO:0030252growth hormone secretionTAS16511605 
GO:0007186G-protein coupled receptor protein signaling pathwayIDA8688086 
GO:0007165signal transductionIEA-
GO:0008343adult feeding behaviorISS-
GO:0009755hormone-mediated signalingIDA8688086 
GO:0008154actin polymerization or depolymerizationIDA15232612 
GO:0032100positive regulation of appetiteISS-
GO:0040018positive regulation of multicellular organism growthIMP16511605 
GO:0032691negative regulation of interleukin-1 beta productionIDA15232612 
GO:0042536negative regulation of tumor necrosis factor biosynthetic processIDA15232612 
GO:0050728negative regulation of inflammatory responseIDA15232612 
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathwayIEA-
GO:0046697decidualizationIDA17494105 
GO:0045409negative regulation of interleukin-6 biosynthetic processIDA15232612 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionIDAneuron, axon, neurite, dendrite (GO term level: 5)12890514 
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA8688086 
GO:0005886plasma membraneIEA-
GO:0045121membrane raftIDA15232612 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway