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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: AMPH

Summary

GeneID

273

Symbol

AMPH

Synonyms

AMPH1

Description

amphiphysin

Locus tag

Gene type

protein-coding

Map location

7p14-p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 4

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.252

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

TAS

neuron, Synap, Neurotransmitter (GO term level: 6)

9182667

GO:0048488

synaptic vesicle endocytosis

IEA

axon, Synap, Neurotransmitter (GO term level: 7)

GO:0007612

learning

IEA

GO:0006897

endocytosis

TAS

9182667

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008021

synaptic vesicle

IEA

Synap, Neurotransmitter (GO term level: 12)

GO:0008021

synaptic vesicle

TAS

Synap, Neurotransmitter (GO term level: 12)

1628617

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005737

cytoplasm

IEA

GO:0016020

membrane

IEA

GO:0015629

actin cytoskeleton

TAS

9182667

GO:0030054

cell junction

IEA

GO:0031410

cytoplasmic vesicle

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP1B1	ADTB1 \| AP105A \| BAM22 \| CLAPB2	adaptor-related protein complex 1, beta 1 subunit	Reconstituted Complex	BioGRID	9280305
AP2A2	ADTAB \| CLAPA2 \| HIP9 \| HYPJ	adaptor-related protein complex 2, alpha 2 subunit	Reconstituted Complex	BioGRID	9280305
BIN1	AMPH2 \| AMPHL \| DKFZp547F068 \| MGC10367 \| SH3P9	bridging integrator 1	-	HPRD,BioGRID	9348539
CABIN1	CAIN \| KIAA0330 \| PPP3IN	calcineurin binding protein 1	-	HPRD,BioGRID	10931822
CDK5R1	CDK5P35 \| CDK5R \| MGC33831 \| NCK5A \| p23 \| p25 \| p35 \| p35nck5a	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Amphiphysin 1 interacts with p35. This interaction was modeled on a demonstrated interaction between human amphiphysin 1 and rat p35.	BIND	11113134
CDK5R1		cyclin-dependent kinase 5, regulatory subunit 1 (p35)	-	HPRD,BioGRID	11113134
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD	9195986 \|9280305 \|9603201
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	in vitro in vivo Reconstituted Complex	BioGRID	9195986 \|9603201
DNM1	DNM	dynamin 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9148966 \|9280305 \|9341169 \|9348539 \|11877424
DNM1	DNM	dynamin 1	-	HPRD	9148966 \|9348539 \|9694653 \|11877424\|10899172
PLD1	-	phospholipase D1, phosphatidylcholine-specific	Affinity Capture-Western Phenotypic Suppression Reconstituted Complex	BioGRID	10764771
PLD2	-	phospholipase D2	-	HPRD,BioGRID	10764771
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western	BioGRID	12558988
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	Reconstituted Complex	BioGRID	9341169 \|12456676
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	-	HPRD	9315708
SH3GLB1	Bif-1 \| CGI-61 \| KIAA0491 \| dJ612B15.2	SH3-domain GRB2-like endophilin B1	-	HPRD,BioGRID	12456676
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD,BioGRID	10899172
SYNJ1	INPP5G	synaptojanin 1	-	HPRD	10542231 \|14704270
SYNJ1	INPP5G	synaptojanin 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9341169
VTN	V75 \| VN \| VNT	vitronectin	-	HPRD,BioGRID	12565847

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
BIOCARTA_NDKDYNAMIN_PATHWAY	21	15	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN	84	63	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN	193	112	All SZGR genes in this pathway
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER	28	21	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN	57	45	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP	412	249	All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE	35	28	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_DN	12	9	All SZGR genes in this pathway
TAVAZOIE_METASTASIS	108	68	All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP	41	26	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_DN	115	73	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	1073	1079	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-153	977	983	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-26	259	265	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	259	265	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-28	947	953	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-330	231	237	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-448	977	983	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.