Gene Page: GLRA1

Summary ?
GeneID2741
SymbolGLRA1
SynonymsHKPX1|STHE
Descriptionglycine receptor alpha 1
ReferenceMIM:138491|HGNC:HGNC:4326|Ensembl:ENSG00000145888|HPRD:00719|Vega:OTTHUMG00000130121
Gene typeprotein-coding
Map location5q32
Pascal p-value0.407
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0004890GABA-A receptor activityIEAGABA (GO term level: 7)-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI11929858 
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0016934extracellular-glycine-gated chloride channel activityIDA2155780 |8137830 
GO:0016594glycine bindingIDA2155780 |15748848 
GO:0030977taurine bindingIDA15748848 
GO:0031404chloride ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051970negative regulation of transmission of nerve impulseIMPneuron (GO term level: 7)11973623 
GO:0060080regulation of inhibitory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0060012synaptic transmission, glycinergicIEAneuron, Synap, Neurotransmitter (GO term level: 8)-
GO:0007218neuropeptide signaling pathwayIDANeurotransmitter (GO term level: 8)2155780 
GO:0002087regulation of respiratory gaseous exchange by neurological processIEABrain (GO term level: 6)-
GO:0001508regulation of action potentialIEA-
GO:0001964startle responseIMP8298642 |11973623 
GO:0007628adult walking behaviorIEA-
GO:0007601visual perceptionIEA-
GO:0006821chloride transportIDA8137830 
GO:0006811ion transportIDA2155780 
GO:0006936muscle contractionIMP11973623 
GO:0007340acrosome reactionIEA-
GO:0060013righting reflexIEA-
GO:0050884neuromuscular process controlling postureIEA-
GO:0043576regulation of respiratory gaseous exchangeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005622intracellularIEA-
GO:0005624membrane fractionIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIDA7506679 
GO:0005887integral to plasma membraneIMP11973623 
GO:0005887integral to plasma membraneNAS2155780 
GO:0030054cell junctionIEA-
GO:0043231intracellular membrane-bounded organelleIDA7506679 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 5542All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 2121All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 8255All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 8959All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 8148All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228119All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15025311Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG