SZGR2

Summary ?

GeneID	2776
Symbol	GNAQ
Synonyms	CMC1\|G-ALPHA-q\|GAQ\|SWS
Description	G protein subunit alpha q
Reference	MIM:600998\|HGNC:HGNC:4390\|Ensembl:ENSG00000156052\|HPRD:02998\|Vega:OTTHUMG00000020059
Gene type	protein-coding
Map location	9q21
Pascal p-value	0.549
Fetal beta	1.238
eGene	Cerebellar Hemisphere Cerebellum
Support	G-PROTEIN RELAY METABOTROPIC GLUTAMATE RECEPTOR G2Cdb.human_mGluR5 G2Cdb.humanPSP Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 4
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.3158

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
COX7A1	0.46	0.33
TAF13	0.41	0.31
AC099797.1	0.41	0.24
ACYP2	0.41	0.34
PNKD	0.40	0.34
C9orf3	0.40	0.35
TSPAN8	0.40	0.34
P2RX6	0.39	0.29
BRP44L	0.39	0.28
OLR1	0.39	0.27

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GPRIN1	-0.30	-0.28
GMIP	-0.30	-0.29
SNX26	-0.30	-0.28
FAM171A2	-0.30	-0.28
ISYNA1	-0.29	-0.31
SHF	-0.29	-0.27
CRMP1	-0.29	-0.26
C19orf57	-0.29	-0.26
KIAA1543	-0.29	-0.26
FARP1	-0.29	-0.28

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	IEA		-
GO:0003924	GTPase activity	TAS		9238049
GO:0005525	GTP binding	IEA		-
GO:0019001	guanyl nucleotide binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016322	neuron remodeling	IEA	neuron, axon, dendrite (GO term level: 11)	-
GO:0060158	dopamine receptor, phospholipase C activating pathway	IEA	dopamine (GO term level: 10)	-
GO:0007215	glutamate signaling pathway	IEA	glutamate (GO term level: 7)	-
GO:0021884	forebrain neuron development	IEA	neuron, Brain (GO term level: 11)	-
GO:0001501	skeletal system development	IEA		-
GO:0001508	regulation of action potential	IEA		-
GO:0007202	activation of phospholipase C activity	TAS		8825633
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	IEA		-
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA		-
GO:0006471	protein amino acid ADP-ribosylation	IEA		-
GO:0007165	signal transduction	IEA		-
GO:0009791	post-embryonic development	IEA		-
GO:0048066	pigmentation during development	IEA		-
GO:0007507	heart development	IEA		-
GO:0007610	behavior	IEA		-
GO:0007596	blood coagulation	TAS		9238049
GO:0042733	embryonic digit morphogenesis	IEA		-
GO:0045634	regulation of melanocyte differentiation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	TAS		9175863
GO:0005886	plasma membrane	EXP		1851174 \|2841328 \|9198220
GO:0005886	plasma membrane	TAS		9175863 \|10633085

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRBK1	BARK1 \| BETA-ARK1 \| FLJ16718 \| GRK2	adrenergic, beta, receptor kinase 1	-	HPRD,BioGRID	12885252
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD,BioGRID	11278452
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD,BioGRID	9770463
CHRM3	HM3	cholinergic receptor, muscarinic 3	-	HPRD	7629074
CRHR1	CRF-R \| CRF1 \| CRFR1 \| CRH-R1h \| CRHR \| CRHR1f	corticotropin releasing hormone receptor 1	-	HPRD,BioGRID	10598591
FFAR1	FFA1R \| GPCR40 \| GPR40	free fatty acid receptor 1	-	HPRD,BioGRID	12496284 \|12629551
FFAR2	FFA2R \| GPR43	free fatty acid receptor 2	-	HPRD	12711604
GALR2	GALNR2 \| MGC125983 \| MGC125984	galanin receptor 2	-	HPRD	9685625
GRM2	GLUR2 \| GPRC1B \| MGLUR2 \| mGlu2	glutamate receptor, metabotropic 2	-	HPRD	8863838
GRM4	GPRC1D \| MGLUR4 \| mGlu4	glutamate receptor, metabotropic 4	-	HPRD	8863838
GRM7	FLJ40498 \| GLUR7 \| GPRC1G \| MGLUR7 \| mGlu7	glutamate receptor, metabotropic 7	-	HPRD,BioGRID	10550060
HTR2A	5-HT2A \| HTR2	5-hydroxytryptamine (serotonin) receptor 2A	-	HPRD	11916537
HTR2B	5-HT(2B) \| 5-HT2B	5-hydroxytryptamine (serotonin) receptor 2B	-	HPRD	11916537
PIK3CA	MGC142161 \| MGC142163 \| PI3K \| p110-alpha	phosphoinositide-3-kinase, catalytic, alpha polypeptide	-	HPRD,BioGRID	12704201
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Affinity Capture-Western	BioGRID	12704201
PLCB1	FLJ45792 \| PI-PLC \| PLC-154 \| PLC-I \| PLC154	phospholipase C, beta 1 (phosphoinositide-specific)	-	HPRD,BioGRID	11753430 \|12193606
PLCB2	FLJ38135	phospholipase C, beta 2	-	HPRD	11753430
PTGIR	IP \| MGC102830 \| PRIPR	prostaglandin I2 (prostacyclin) receptor (IP)	-	HPRD	10446129
PTGIR	IP \| MGC102830 \| PRIPR	prostaglandin I2 (prostacyclin) receptor (IP)	Affinity Capture-Western	BioGRID	11443126
RGS16	A28-RGS14 \| A28-RGS14P \| RGS-R	regulator of G-protein signaling 16	Affinity Capture-Western Reconstituted Complex	BioGRID	14634662
RGS18	RGS13	regulator of G-protein signaling 18	-	HPRD,BioGRID	11955952
RGS2	G0S8	regulator of G-protein signaling 2, 24kDa	Reconstituted Complex	BioGRID	12885252
RGS2	G0S8	regulator of G-protein signaling 2, 24kDa	-	HPRD	9405622
RGS4	DKFZp761F1924 \| MGC2124 \| MGC60244 \| RGP4 \| SCZD9	regulator of G-protein signaling 4	-	HPRD	9405622\|9660808
RGS4	DKFZp761F1924 \| MGC2124 \| MGC60244 \| RGP4 \| SCZD9	regulator of G-protein signaling 4	Affinity Capture-Western Reconstituted Complex	BioGRID	9660808 \|14634662
RGS5	MST092 \| MST106 \| MST129 \| MSTP032 \| MSTP092 \| MSTP106 \| MSTP129	regulator of G-protein signaling 5	-	HPRD,BioGRID	11253162
RGS7	-	regulator of G-protein signaling 7	-	HPRD,BioGRID	12670932
RIC8A	MGC104517 \| MGC131931 \| MGC148073 \| MGC148074 \| RIC8 \| synembryn	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	HPRD,BioGRID	12509430 \|12652642
RIC8B	FLJ10620 \| MGC39476 \| RIC8 \| hSyn	resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)	-	HPRD	12652642
S1PR2	AGR16 \| EDG-5 \| EDG5 \| Gpcr13 \| H218 \| LPB2 \| S1P2	sphingosine-1-phosphate receptor 2	-	HPRD	10488065
S1PR3	EDG-3 \| EDG3 \| FLJ37523 \| FLJ93220 \| LPB3 \| MGC71696 \| S1P3	sphingosine-1-phosphate receptor 3	-	HPRD	10488065
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	-	HPRD,BioGRID	12193606
TBXA2R	TXA2-R	thromboxane A2 receptor	-	HPRD,BioGRID	9152406 \|12193606
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD	8188646
TTC1	FLJ46404 \| TPR1	tetratricopeptide repeat domain 1	G-alpha-q interacts with TPR1.	BIND	12748287
TTC1	FLJ46404 \| TPR1	tetratricopeptide repeat domain 1	-	HPRD,BioGRID	12748287
VIPR1	FLJ41949 \| HVR1 \| II \| PACAP-R-2 \| RDC1 \| VAPC1 \| VIPR \| VIRG \| VPAC1 \| VPCAP1R	vasoactive intestinal peptide receptor 1	-	HPRD,BioGRID	11812005

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY	21	17	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY	31	22	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY	27	23	All SZGR 2.0 genes in this pathway
ST ADRENERGIC	36	29	All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY	28	22	All SZGR 2.0 genes in this pathway
ST PAC1 RECEPTOR PATHWAY	7	5	All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY	27	25	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY	35	27	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY	21	14	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS	184	116	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	11	9	All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1	25	16	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION	31	19	All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	14	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN	139	76	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN	141	84	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q	116	71	All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS	36	25	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN	47	33	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP	92	58	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN	50	32	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN	87	59	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3	160	103	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS UP	48	28	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-3p	851	858	1A,m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-182	997	1004	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-378	469	475	m8	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-96	998	1004	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GNAQ