Gene Page: GNAQ

Summary
GeneID  2776
Symbol  GNAQ
Synonyms  G-ALPHA-q|GAQ
Description  guanine nucleotide binding protein (G protein), q polypeptide
See related  HGNC:4390|MIM:600998|Ensembl:ENSG00000156052|HPRD:02998|
Locus tag  RP11-494N1.1
Gene type  protein-coding
Map location  9q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.3158 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COX7A10.460.33
TAF130.410.31
AC099797.10.410.24
ACYP20.410.34
PNKD0.400.34
C9orf30.400.35
TSPAN80.400.34
P2RX60.390.29
BRP44L0.390.28
OLR10.390.27
Top 10 negatively co-expressed genes
GPRIN1-0.30-0.28
GMIP-0.30-0.29
SNX26-0.30-0.28
FAM171A2-0.30-0.28
ISYNA1-0.29-0.31
SHF-0.29-0.27
CRMP1-0.29-0.26
C19orf57-0.29-0.26
KIAA1543-0.29-0.26
FARP1-0.29-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0003924GTPase activityTAS9238049 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016322neuron remodelingIEAneuron, axon, dendrite (GO term level: 11)-
GO:0060158dopamine receptor, phospholipase C activating pathwayIEAdopamine (GO term level: 10)-
GO:0007215glutamate signaling pathwayIEAglutamate (GO term level: 7)-
GO:0021884forebrain neuron developmentIEAneuron, Brain (GO term level: 11)-
GO:0001501skeletal system developmentIEA-
GO:0001508regulation of action potentialIEA-
GO:0007202activation of phospholipase C activityTAS8825633 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0006471protein amino acid ADP-ribosylationIEA-
GO:0007165signal transductionIEA-
GO:0009791post-embryonic developmentIEA-
GO:0048066pigmentation during developmentIEA-
GO:0007507heart developmentIEA-
GO:0007610behaviorIEA-
GO:0007596blood coagulationTAS9238049 
GO:0042733embryonic digit morphogenesisIEA-
GO:0045634regulation of melanocyte differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS9175863 
GO:0005886plasma membraneEXP1851174 |2841328 |9198220 
GO:0005886plasma membraneTAS9175863 |10633085 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1-HPRD,BioGRID12885252 
AKAP13AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbcA kinase (PRKA) anchor protein 13-HPRD,BioGRID11278452 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID9770463 
CHRM3HM3cholinergic receptor, muscarinic 3-HPRD7629074 
CRHR1CRF-R | CRF1 | CRFR1 | CRH-R1h | CRHR | CRHR1fcorticotropin releasing hormone receptor 1-HPRD,BioGRID10598591 
FFAR1FFA1R | GPCR40 | GPR40free fatty acid receptor 1-HPRD,BioGRID12496284 |12629551 
FFAR2FFA2R | GPR43free fatty acid receptor 2-HPRD12711604 
GALR2GALNR2 | MGC125983 | MGC125984galanin receptor 2-HPRD9685625 
GRM2GLUR2 | GPRC1B | MGLUR2 | mGlu2glutamate receptor, metabotropic 2-HPRD8863838 
GRM4GPRC1D | MGLUR4 | mGlu4glutamate receptor, metabotropic 4-HPRD8863838 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7-HPRD,BioGRID10550060 
HTR2A5-HT2A | HTR25-hydroxytryptamine (serotonin) receptor 2A-HPRD11916537 
HTR2B5-HT(2B) | 5-HT2B5-hydroxytryptamine (serotonin) receptor 2B-HPRD11916537 
PIK3CAMGC142161 | MGC142163 | PI3K | p110-alphaphosphoinositide-3-kinase, catalytic, alpha polypeptide-HPRD,BioGRID12704201 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-WesternBioGRID12704201 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)-HPRD,BioGRID11753430 |12193606 
PLCB2FLJ38135phospholipase C, beta 2-HPRD11753430 
PTGIRIP | MGC102830 | PRIPRprostaglandin I2 (prostacyclin) receptor (IP)-HPRD10446129 
Affinity Capture-WesternBioGRID11443126 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16Affinity Capture-Western
Reconstituted Complex		BioGRID14634662 
RGS18RGS13regulator of G-protein signaling 18-HPRD,BioGRID11955952 
RGS2G0S8regulator of G-protein signaling 2, 24kDaReconstituted ComplexBioGRID12885252 
-HPRD9405622 
RGS4DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9regulator of G-protein signaling 4-HPRD9405622|9660808 
Affinity Capture-Western
Reconstituted Complex		BioGRID9660808 |14634662 
RGS5MST092 | MST106 | MST129 | MSTP032 | MSTP092 | MSTP106 | MSTP129regulator of G-protein signaling 5-HPRD,BioGRID11253162 
RGS7-regulator of G-protein signaling 7-HPRD,BioGRID12670932 
RIC8AMGC104517 | MGC131931 | MGC148073 | MGC148074 | RIC8 | synembrynresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)-HPRD,BioGRID12509430 |12652642 
RIC8BFLJ10620 | MGC39476 | RIC8 | hSynresistance to inhibitors of cholinesterase 8 homolog B (C. elegans)-HPRD12652642 
S1PR2AGR16 | EDG-5 | EDG5 | Gpcr13 | H218 | LPB2 | S1P2sphingosine-1-phosphate receptor 2-HPRD10488065 
S1PR3EDG-3 | EDG3 | FLJ37523 | FLJ93220 | LPB3 | MGC71696 | S1P3sphingosine-1-phosphate receptor 3-HPRD10488065 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1-HPRD,BioGRID12193606 
TBXA2RTXA2-Rthromboxane A2 receptor-HPRD,BioGRID9152406 |12193606 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptor-HPRD8188646 
TTC1FLJ46404 | TPR1tetratricopeptide repeat domain 1G-alpha-q interacts with TPR1.BIND12748287 
-HPRD,BioGRID12748287 
VIPR1FLJ41949 | HVR1 | II | PACAP-R-2 | RDC1 | VAPC1 | VIPR | VIRG | VPAC1 | VPCAP1Rvasoactive intestinal peptide receptor 1-HPRD,BioGRID11812005 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
BIOCARTA_CCR5_PATHWAY 2016All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY 2723All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_GAQ_PATHWAY 2822All SZGR genes in this pathway
ST_PAC1_RECEPTOR_PATHWAY 75All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_THROMBIN_PAR4_PATHWAY 1511All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE 119All SZGR genes in this pathway
REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 2516All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SIGNAL_AMPLIFICATION 3119All SZGR genes in this pathway
REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 2314All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q 11671All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_DN 4733All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP 9258All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN 5032All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_UP 4828All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-3p8518581A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-18299710041A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-378469475m8hsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-9699810041Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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