Gene Page: ANG

Summary ?
GeneID283
SymbolANG
SynonymsALS9|HEL168|RAA1|RNASE4|RNASE5
Descriptionangiogenin, ribonuclease, RNase A family, 5
ReferenceMIM:105850|HGNC:HGNC:483|Ensembl:ENSG00000214274|HPRD:00105|Vega:OTTHUMG00000029576
Gene typeprotein-coding
Map location14q11.1-q11.2
Sherlock p-value0.091
Fetal beta0.286
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.047 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10958910chr910134759ANG2830.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KCNC10.820.85
SLC45A40.820.83
STX1B0.780.82
RNF1570.770.82
KCNC30.770.72
ATP2B30.770.82
KLC20.770.79
CAMTA10.760.79
IFFO10.760.78
STXBP10.760.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RHOC-0.45-0.56
DBI-0.43-0.53
GNG11-0.43-0.54
C1orf54-0.42-0.56
C1orf61-0.42-0.55
AF347015.21-0.41-0.48
RAB34-0.39-0.47
MYL12A-0.38-0.48
VAMP5-0.37-0.46
IL32-0.37-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)9122172 
GO:0003779actin bindingIDA7679494 |11782452 
GO:0003676nucleic acid bindingIEA-
GO:0003677DNA bindingIC10649442 
GO:0005507copper ion bindingIDA9245697 
GO:0004540ribonuclease activityIDA2424496 |2730651 
GO:0004519endonuclease activityIEA-
GO:0004519endonuclease activityTAS10103013 
GO:0004522pancreatic ribonuclease activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008201heparin bindingIDA10103013 
GO:0019843rRNA bindingTAS2457905 
GO:0042277peptide bindingIDA11782452 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001556oocyte maturationNAS11438326 
GO:0001525angiogenesisIMP2479414 |17125737 
GO:0001525angiogenesisTAS16567967 
GO:0001666response to hypoxiaIDA10999833 |15979542 |16490744 
GO:0001666response to hypoxiaNAS15776477 
GO:0001541ovarian follicle developmentNAS12770725 
GO:0001890placenta developmentNAS11984825 
GO:0001938positive regulation of endothelial cell proliferationIDA9122172 |9707554 
GO:0007202activation of phospholipase C activityIMP2457905 
GO:0007154cell communicationNAS10103013 
GO:0009303rRNA transcriptionIMP15735021 
GO:0009725response to hormone stimulusIDA10999833 
GO:0006651diacylglycerol biosynthetic processIDA2457905 
GO:0007275multicellular organismal developmentIEA-
GO:0042327positive regulation of phosphorylationIDA17125737 
GO:0016477cell migrationIMP17125737 
GO:0030154cell differentiationIEA-
GO:0042592homeostatic processNAS15166501 
GO:0030041actin filament polymerizationISS-
GO:0032431activation of phospholipase A2IMP2646638 
GO:0032148activation of protein kinase B activityIMP17125737 
GO:0017148negative regulation of translationIEA-
GO:0050714positive regulation of protein secretionIDA2646638 
GO:0050714positive regulation of protein secretionISS-
GO:0048662negative regulation of smooth muscle cell proliferationIDA10103013 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaISSaxon, dendrite (GO term level: 4)-
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0005576extracellular regionIEA-
GO:0005605basal laminaIDA15166501 
GO:0005615extracellular spaceIDA3663649 |16461950 |16490744 
GO:0005634nucleusIDA10649442 |15735021 
GO:0005730nucleolusISS-
GO:0032311angiogenin-PRI complexIPI3470787 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BARRIER COLON CANCER RECURRENCE UP 4228All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171112All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP 13085All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN 9158All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN 10472All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238135All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP 55All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 14085All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 12684All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP 9871All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA UP 1212All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway