Gene Page: ANG

Summary
GeneID  283
Symbol  ANG
Synonyms  ALS9|HEL168|MGC22466|MGC71966|RNASE4|RNASE5
Description  angiogenin, ribonuclease, RNase A family, 5
See related  HGNC:483|MIM:105850|Ensembl:ENSG00000214274|HPRD:00105|
Locus tag  -
Gene type  protein-coding
Map location  14q11.1-q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KCNC10.820.85
SLC45A40.820.83
STX1B0.780.82
RNF1570.770.82
KCNC30.770.72
ATP2B30.770.82
KLC20.770.79
CAMTA10.760.79
IFFO10.760.78
STXBP10.760.81
Top 10 negatively co-expressed genes
RHOC-0.45-0.56
DBI-0.43-0.53
GNG11-0.43-0.54
C1orf54-0.42-0.56
C1orf61-0.42-0.55
AF347015.21-0.41-0.48
RAB34-0.39-0.47
MYL12A-0.38-0.48
VAMP5-0.37-0.46
IL32-0.37-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)9122172 
GO:0003779actin bindingIDA7679494 |11782452 
GO:0003676nucleic acid bindingIEA-
GO:0003677DNA bindingIC10649442 
GO:0005507copper ion bindingIDA9245697 
GO:0004540ribonuclease activityIDA2424496 |2730651 
GO:0004519endonuclease activityIEA-
GO:0004519endonuclease activityTAS10103013 
GO:0004522pancreatic ribonuclease activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008201heparin bindingIDA10103013 
GO:0019843rRNA bindingTAS2457905 
GO:0042277peptide bindingIDA11782452 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001556oocyte maturationNAS11438326 
GO:0001525angiogenesisIMP2479414 |17125737 
GO:0001525angiogenesisTAS16567967 
GO:0001666response to hypoxiaIDA10999833 |15979542 |16490744 
GO:0001666response to hypoxiaNAS15776477 
GO:0001541ovarian follicle developmentNAS12770725 
GO:0001890placenta developmentNAS11984825 
GO:0001938positive regulation of endothelial cell proliferationIDA9122172 |9707554 
GO:0007202activation of phospholipase C activityIMP2457905 
GO:0007154cell communicationNAS10103013 
GO:0009303rRNA transcriptionIMP15735021 
GO:0009725response to hormone stimulusIDA10999833 
GO:0006651diacylglycerol biosynthetic processIDA2457905 
GO:0007275multicellular organismal developmentIEA-
GO:0042327positive regulation of phosphorylationIDA17125737 
GO:0016477cell migrationIMP17125737 
GO:0030154cell differentiationIEA-
GO:0042592homeostatic processNAS15166501 
GO:0030041actin filament polymerizationISS-
GO:0032431activation of phospholipase A2IMP2646638 
GO:0032148activation of protein kinase B activityIMP17125737 
GO:0017148negative regulation of translationIEA-
GO:0050714positive regulation of protein secretionIDA2646638 
GO:0050714positive regulation of protein secretionISS-
GO:0048662negative regulation of smooth muscle cell proliferationIDA10103013 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaISSaxon, dendrite (GO term level: 4)-
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0005576extracellular regionIEA-
GO:0005605basal laminaIDA15166501 
GO:0005615extracellular spaceIDA3663649 |16461950 |16490744 
GO:0005634nucleusIDA10649442 |15735021 
GO:0005730nucleolusISS-
GO:0032311angiogenin-PRI complexIPI3470787 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD8127865 
ACTN2CMD1AAactinin, alpha 2ANG interacts with ACTN2. This interaction was modeled on a demonstrated interaction between ANG from unspecified species and human ACTN2.BIND15737636 
ATP6AP116A | ATP6IP1 | ATP6S1 | Ac45 | CF2 | MGC129781 | VATPS1 | XAP-3 | XAP3ATPase, H+ transporting, lysosomal accessory protein 1Two-hybridBioGRID16169070 
PTEN10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1phosphatase and tensin homologTwo-hybridBioGRID16169070 
RNH1MGC18200 | MGC4569 | MGC54054 | RAI | RNHribonuclease/angiogenin inhibitor 1-HPRD,BioGRID2276743 |2742853 
|9311977 
TDGF1CR | CRGF | CRIPTO | Cripto-1teratocarcinoma-derived growth factor 1Two-hybridBioGRID16169070 
TNFSF8CD153 | CD30L | CD30LG | MGC138144tumor necrosis factor (ligand) superfamily, member 8-HPRD11751393 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BARRIER_COLON_CANCER_RECURRENCE_UP 4228All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP 13085All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN 9158All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP 55All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
MENSE_HYPOXIA_UP 9871All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_UP 1212All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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