SZGR2

Summary ?

GeneID	2917
Symbol	GRM7
Synonyms	GLUR7\|GPRC1G\|MGLU7\|MGLUR7\|PPP1R87
Description	glutamate receptor, metabotropic 7
Reference	MIM:604101\|HGNC:HGNC:4599\|Ensembl:ENSG00000196277\|HPRD:04979\|Vega:OTTHUMG00000125549
Gene type	protein-coding
Map location	3p26.1-p25.1
Pascal p-value	0.069
Sherlock p-value	0.1
Fetal beta	-0.798
DMG	1 (# studies)
Support	GPCR SIGNALLING G2Cdb.humanPSD G2Cdb.humanPSP Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	2	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 3
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0018

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg12479516	3	7098132	GRM7	3.895E-4	0.539	0.043	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SEMA3B	0.94	0.87
PCTK3	0.93	0.93
ATPGD1	0.93	0.91
MAG	0.93	0.92
TMC6	0.92	0.91
LDB3	0.92	0.90
CHADL	0.92	0.90
CYP27A1	0.92	0.90
ERBB3	0.91	0.90
S1PR5	0.91	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MED19	-0.60	-0.72
NKIRAS2	-0.60	-0.65
NR2C2AP	-0.60	-0.74
STMN1	-0.59	-0.71
TRNAU1AP	-0.59	-0.69
KIAA1949	-0.58	-0.64
POLB	-0.58	-0.72
TUBB2B	-0.58	-0.67
ING4	-0.58	-0.69
ZNF821	-0.58	-0.65

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0005245	voltage-gated calcium channel activity	IEA		-
GO:0005246	calcium channel regulator activity	IEA		-
GO:0030165	PDZ domain binding	TAS		12052533
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007268	synaptic transmission	TAS	neuron, Synap, Neurotransmitter (GO term level: 6)	9473604
GO:0001662	behavioral fear response	IEA		-
GO:0001661	conditioned taste aversion	IEA		-
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA		-
GO:0007194	negative regulation of adenylate cyclase activity	TAS		9473604
GO:0007165	signal transduction	IEA		-
GO:0007608	sensory perception of smell	IEA		-
GO:0050896	response to stimulus	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0048787	presynaptic active zone membrane	TAS	Synap, Neurotransmitter (GO term level: 6)	12052533
GO:0045211	postsynaptic membrane	TAS	Synap, Neurotransmitter (GO term level: 5)	12052533
GO:0005886	plasma membrane	IEA		-
GO:0005887	integral to plasma membrane	TAS		9473604

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	10488094 \|11953448
CALM2	CAMII \| PHKD \| PHKD2	calmodulin 2 (phosphorylase kinase, delta)	-	HPRD	11953448
CALM3	PHKD \| PHKD3	calmodulin 3 (phosphorylase kinase, delta)	-	HPRD	11953448
GNAQ	G-ALPHA-q \| GAQ	guanine nucleotide binding protein (G protein), q polypeptide	-	HPRD,BioGRID	10550060
GRIP1	GRIP	glutamate receptor interacting protein 1	GRIP interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b.	BIND	11891216
PICK1	MGC15204 \| PICK \| PRKCABP	protein interacting with PRKCA 1	PICK1 interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between PICK1 from an unspecified species and human mGluR7b.	BIND	11891216
PICK1	MGC15204 \| PICK \| PRKCABP	protein interacting with PRKCA 1	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	11007882
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	Affinity Capture-Western	BioGRID	11007882
SDCBP	MDA-9 \| ST1 \| SYCL \| TACIP18	syndecan binding protein (syntenin)	Syntenin interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b.	BIND	11891216
TUBA1A	B-ALPHA-1 \| FLJ25113 \| LIS3 \| TUBA3	tubulin, alpha 1a	-	HPRD	11953448
TUBA1B	K-ALPHA-1	tubulin, alpha 1b	-	HPRD	11953448
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	11953448
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	-	HPRD	11953448
TUBA8	TUBAL2	tubulin, alpha 8	-	HPRD	11953448

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	15	11	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC UP	83	50	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP	390	236	All SZGR 2.0 genes in this pathway
SCHLESINGER H3K27ME3 IN NORMAL AND METHYLATED IN CANCER	28	21	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN	102	67	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3	79	59	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3	341	243	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN	180	116	All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP	163	111	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	397	403	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p	176	182	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497	1001	1007	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	399	405	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	1092	1098	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-19	396	402	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	396	402	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-25/32/92/363/367	837	843	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-3p	1042	1048	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1042	1048	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-34/449	210	217	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-346	532	538	m8	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-495	434	440	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GRM7