Gene Page: GSTP1
Summary ?
| GeneID | 2950 |
| Symbol | GSTP1 |
| Synonyms | DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI |
| Description | glutathione S-transferase pi 1 |
| Reference | MIM:134660|HGNC:HGNC:4638|Ensembl:ENSG00000084207|HPRD:00614|Vega:OTTHUMG00000137430 |
| Gene type | protein-coding |
| Map location | 11q13 |
| Pascal p-value | 0.322 |
| Sherlock p-value | 0.586 |
| Fetal beta | 0.356 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
| Support | CELL METABOLISM |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs516349 | 0 | GSTP1 | 2950 | 0.13 | trans | |||
| rs1476792 | 11 | 67196237 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -154829 | gtex_brain_ba24 |
| rs12573992 | 11 | 67197757 | GSTP1 | ENSG00000084207.11 | 2.297E-6 | 0 | -153309 | gtex_brain_ba24 |
| rs1638588 | 11 | 67199706 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -151360 | gtex_brain_ba24 |
| rs4930427 | 11 | 67200819 | GSTP1 | ENSG00000084207.11 | 2.297E-6 | 0 | -150247 | gtex_brain_ba24 |
| rs1790753 | 11 | 67201008 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -150058 | gtex_brain_ba24 |
| rs1790752 | 11 | 67202044 | GSTP1 | ENSG00000084207.11 | 1.078E-6 | 0 | -149022 | gtex_brain_ba24 |
| rs13859 | 11 | 67202156 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -148910 | gtex_brain_ba24 |
| rs10274 | 11 | 67202826 | GSTP1 | ENSG00000084207.11 | 2.281E-6 | 0 | -148240 | gtex_brain_ba24 |
| rs12787021 | 11 | 67204342 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -146724 | gtex_brain_ba24 |
| rs869736 | 11 | 67205462 | GSTP1 | ENSG00000084207.11 | 1.083E-6 | 0 | -145604 | gtex_brain_ba24 |
| rs872375 | 11 | 67205978 | GSTP1 | ENSG00000084207.11 | 1.471E-6 | 0 | -145088 | gtex_brain_ba24 |
| rs2302264 | 11 | 67207426 | GSTP1 | ENSG00000084207.11 | 2.297E-6 | 0 | -143640 | gtex_brain_ba24 |
| rs1808279 | 11 | 67211569 | GSTP1 | ENSG00000084207.11 | 9.093E-7 | 0 | -139497 | gtex_brain_ba24 |
| rs1638555 | 11 | 67213284 | GSTP1 | ENSG00000084207.11 | 6.716E-7 | 0 | -137782 | gtex_brain_ba24 |
| rs1638556 | 11 | 67213518 | GSTP1 | ENSG00000084207.11 | 6.648E-7 | 0 | -137548 | gtex_brain_ba24 |
| rs7479801 | 11 | 67213748 | GSTP1 | ENSG00000084207.11 | 6.591E-7 | 0 | -137318 | gtex_brain_ba24 |
| rs2109123 | 11 | 67213956 | GSTP1 | ENSG00000084207.11 | 6.534E-7 | 0 | -137110 | gtex_brain_ba24 |
| rs1638557 | 11 | 67215988 | GSTP1 | ENSG00000084207.11 | 2.314E-7 | 0 | -135078 | gtex_brain_ba24 |
| rs1893973 | 11 | 67217518 | GSTP1 | ENSG00000084207.11 | 2.633E-7 | 0 | -133548 | gtex_brain_ba24 |
| rs1790761 | 11 | 67221854 | GSTP1 | ENSG00000084207.11 | 4.8E-7 | 0 | -129212 | gtex_brain_ba24 |
| rs1638564 | 11 | 67223920 | GSTP1 | ENSG00000084207.11 | 5.543E-7 | 0 | -127146 | gtex_brain_ba24 |
| rs1638565 | 11 | 67223921 | GSTP1 | ENSG00000084207.11 | 4.219E-7 | 0 | -127145 | gtex_brain_ba24 |
| rs7114510 | 11 | 67224594 | GSTP1 | ENSG00000084207.11 | 1.241E-7 | 0 | -126472 | gtex_brain_ba24 |
| rs11601325 | 11 | 67227006 | GSTP1 | ENSG00000084207.11 | 1.232E-7 | 0 | -124060 | gtex_brain_ba24 |
| rs7131041 | 11 | 67230184 | GSTP1 | ENSG00000084207.11 | 2.137E-6 | 0 | -120882 | gtex_brain_ba24 |
| rs3741168 | 11 | 67235351 | GSTP1 | ENSG00000084207.11 | 2.975E-7 | 0 | -115715 | gtex_brain_ba24 |
| rs1628442 | 11 | 67238632 | GSTP1 | ENSG00000084207.11 | 2.975E-7 | 0 | -112434 | gtex_brain_ba24 |
| rs36089024 | 11 | 67244644 | GSTP1 | ENSG00000084207.11 | 1.232E-7 | 0 | -106422 | gtex_brain_ba24 |
| rs61889868 | 11 | 67245831 | GSTP1 | ENSG00000084207.11 | 2.781E-7 | 0 | -105235 | gtex_brain_ba24 |
| rs12799746 | 11 | 67246630 | GSTP1 | ENSG00000084207.11 | 7.686E-7 | 0 | -104436 | gtex_brain_ba24 |
| rs35392564 | 11 | 67251107 | GSTP1 | ENSG00000084207.11 | 1.557E-7 | 0 | -99959 | gtex_brain_ba24 |
| rs595130 | 11 | 67252989 | GSTP1 | ENSG00000084207.11 | 3.261E-7 | 0 | -98077 | gtex_brain_ba24 |
| rs7110021 | 11 | 67253564 | GSTP1 | ENSG00000084207.11 | 7.281E-7 | 0 | -97502 | gtex_brain_ba24 |
| rs630172 | 11 | 67253673 | GSTP1 | ENSG00000084207.11 | 2.957E-7 | 0 | -97393 | gtex_brain_ba24 |
| rs35787427 | 11 | 67255877 | GSTP1 | ENSG00000084207.11 | 1.232E-7 | 0 | -95189 | gtex_brain_ba24 |
| rs4084113 | 11 | 67257037 | GSTP1 | ENSG00000084207.11 | 4.732E-7 | 0 | -94029 | gtex_brain_ba24 |
| rs4465371 | 11 | 67280620 | GSTP1 | ENSG00000084207.11 | 3.901E-7 | 0 | -70446 | gtex_brain_ba24 |
| rs2276118 | 11 | 67288594 | GSTP1 | ENSG00000084207.11 | 3.004E-7 | 0 | -62472 | gtex_brain_ba24 |
| rs1871034 | 11 | 67293234 | GSTP1 | ENSG00000084207.11 | 1.401E-8 | 0 | -57832 | gtex_brain_ba24 |
| rs4930430 | 11 | 67294198 | GSTP1 | ENSG00000084207.11 | 1.633E-9 | 0 | -56868 | gtex_brain_ba24 |
| rs4930431 | 11 | 67294308 | GSTP1 | ENSG00000084207.11 | 4.493E-8 | 0 | -56758 | gtex_brain_ba24 |
| rs7934075 | 11 | 67295949 | GSTP1 | ENSG00000084207.11 | 6.046E-9 | 0 | -55117 | gtex_brain_ba24 |
| rs1254119 | 11 | 67296669 | GSTP1 | ENSG00000084207.11 | 3.125E-7 | 0 | -54397 | gtex_brain_ba24 |
| rs201527446 | 11 | 67302581 | GSTP1 | ENSG00000084207.11 | 2.184E-7 | 0 | -48485 | gtex_brain_ba24 |
| rs12365485 | 11 | 67302582 | GSTP1 | ENSG00000084207.11 | 8.427E-8 | 0 | -48484 | gtex_brain_ba24 |
| rs57808037 | 11 | 67302853 | GSTP1 | ENSG00000084207.11 | 4.576E-9 | 0 | -48213 | gtex_brain_ba24 |
| rs7938563 | 11 | 67304131 | GSTP1 | ENSG00000084207.11 | 2.307E-8 | 0 | -46935 | gtex_brain_ba24 |
| rs1148883 | 11 | 67304686 | GSTP1 | ENSG00000084207.11 | 1.113E-8 | 0 | -46380 | gtex_brain_ba24 |
| rs1148884 | 11 | 67304760 | GSTP1 | ENSG00000084207.11 | 1.112E-8 | 0 | -46306 | gtex_brain_ba24 |
| rs6591244 | 11 | 67304960 | GSTP1 | ENSG00000084207.11 | 1.897E-8 | 0 | -46106 | gtex_brain_ba24 |
| rs373900613 | 11 | 67305476 | GSTP1 | ENSG00000084207.11 | 2.18E-8 | 0 | -45590 | gtex_brain_ba24 |
| rs535086417 | 11 | 67305490 | GSTP1 | ENSG00000084207.11 | 1.239E-7 | 0 | -45576 | gtex_brain_ba24 |
| rs1871036 | 11 | 67306319 | GSTP1 | ENSG00000084207.11 | 5.96E-9 | 0 | -44747 | gtex_brain_ba24 |
| rs10791906 | 11 | 67307450 | GSTP1 | ENSG00000084207.11 | 1.113E-8 | 0 | -43616 | gtex_brain_ba24 |
| rs4320958 | 11 | 67310334 | GSTP1 | ENSG00000084207.11 | 2.202E-8 | 0 | -40732 | gtex_brain_ba24 |
| rs6591245 | 11 | 67310936 | GSTP1 | ENSG00000084207.11 | 3.208E-9 | 0 | -40130 | gtex_brain_ba24 |
| rs598811 | 11 | 67311676 | GSTP1 | ENSG00000084207.11 | 1.552E-8 | 0 | -39390 | gtex_brain_ba24 |
| rs611663 | 11 | 67312221 | GSTP1 | ENSG00000084207.11 | 1.112E-8 | 0 | -38845 | gtex_brain_ba24 |
| rs34802338 | 11 | 67312466 | GSTP1 | ENSG00000084207.11 | 3.231E-9 | 0 | -38600 | gtex_brain_ba24 |
| rs34721562 | 11 | 67312708 | GSTP1 | ENSG00000084207.11 | 3.462E-9 | 0 | -38358 | gtex_brain_ba24 |
| rs7106423 | 11 | 67314144 | GSTP1 | ENSG00000084207.11 | 2.247E-8 | 0 | -36922 | gtex_brain_ba24 |
| rs7106675 | 11 | 67314269 | GSTP1 | ENSG00000084207.11 | 3.295E-9 | 0 | -36797 | gtex_brain_ba24 |
| rs10896179 | 11 | 67316928 | GSTP1 | ENSG00000084207.11 | 1.264E-8 | 0 | -34138 | gtex_brain_ba24 |
| rs199548820 | 11 | 67317167 | GSTP1 | ENSG00000084207.11 | 9.462E-9 | 0 | -33899 | gtex_brain_ba24 |
| rs58046082 | 11 | 67317169 | GSTP1 | ENSG00000084207.11 | 1.08E-8 | 0 | -33897 | gtex_brain_ba24 |
| rs10896180 | 11 | 67317322 | GSTP1 | ENSG00000084207.11 | 4.955E-9 | 0 | -33744 | gtex_brain_ba24 |
| rs11605586 | 11 | 67317935 | GSTP1 | ENSG00000084207.11 | 2.601E-8 | 0 | -33131 | gtex_brain_ba24 |
| rs2008922 | 11 | 67322367 | GSTP1 | ENSG00000084207.11 | 2.082E-8 | 0 | -28699 | gtex_brain_ba24 |
| rs75649061 | 11 | 67322488 | GSTP1 | ENSG00000084207.11 | 2.551E-8 | 0 | -28578 | gtex_brain_ba24 |
| rs7948478 | 11 | 67324476 | GSTP1 | ENSG00000084207.11 | 2.304E-8 | 0 | -26590 | gtex_brain_ba24 |
| rs7948823 | 11 | 67324583 | GSTP1 | ENSG00000084207.11 | 2.551E-8 | 0 | -26483 | gtex_brain_ba24 |
| rs2508459 | 11 | 67324783 | GSTP1 | ENSG00000084207.11 | 3.536E-8 | 0 | -26283 | gtex_brain_ba24 |
| rs7952081 | 11 | 67324933 | GSTP1 | ENSG00000084207.11 | 4.024E-9 | 0 | -26133 | gtex_brain_ba24 |
| rs12225376 | 11 | 67325245 | GSTP1 | ENSG00000084207.11 | 1.242E-8 | 0 | -25821 | gtex_brain_ba24 |
| rs4930436 | 11 | 67329337 | GSTP1 | ENSG00000084207.11 | 6.077E-9 | 0 | -21729 | gtex_brain_ba24 |
| rs55854833 | 11 | 67329741 | GSTP1 | ENSG00000084207.11 | 6.514E-8 | 0 | -21325 | gtex_brain_ba24 |
| rs684928 | 11 | 67329742 | GSTP1 | ENSG00000084207.11 | 1.469E-8 | 0 | -21324 | gtex_brain_ba24 |
| rs10896181 | 11 | 67330068 | GSTP1 | ENSG00000084207.11 | 2.422E-8 | 0 | -20998 | gtex_brain_ba24 |
| rs10444362 | 11 | 67333090 | GSTP1 | ENSG00000084207.11 | 1.438E-8 | 0 | -17976 | gtex_brain_ba24 |
| rs638140 | 11 | 67333858 | GSTP1 | ENSG00000084207.11 | 1.472E-8 | 0 | -17208 | gtex_brain_ba24 |
| rs1254123 | 11 | 67334812 | GSTP1 | ENSG00000084207.11 | 7.763E-8 | 0 | -16254 | gtex_brain_ba24 |
| rs1269981 | 11 | 67334959 | GSTP1 | ENSG00000084207.11 | 1.412E-8 | 0 | -16107 | gtex_brain_ba24 |
| rs666328 | 11 | 67335538 | GSTP1 | ENSG00000084207.11 | 1.4E-8 | 0 | -15528 | gtex_brain_ba24 |
| rs1262166 | 11 | 67335943 | GSTP1 | ENSG00000084207.11 | 1.391E-8 | 0 | -15123 | gtex_brain_ba24 |
| rs11227837 | 11 | 67336424 | GSTP1 | ENSG00000084207.11 | 3.673E-8 | 0 | -14642 | gtex_brain_ba24 |
| rs645653 | 11 | 67337217 | GSTP1 | ENSG00000084207.11 | 1.646E-8 | 0 | -13849 | gtex_brain_ba24 |
| rs658768 | 11 | 67337808 | GSTP1 | ENSG00000084207.11 | 1.359E-8 | 0 | -13258 | gtex_brain_ba24 |
| rs591434 | 11 | 67337814 | GSTP1 | ENSG00000084207.11 | 1.339E-8 | 0 | -13252 | gtex_brain_ba24 |
| rs7103713 | 11 | 67338242 | GSTP1 | ENSG00000084207.11 | 2.225E-8 | 0 | -12824 | gtex_brain_ba24 |
| rs674783 | 11 | 67339076 | GSTP1 | ENSG00000084207.11 | 1.34E-8 | 0 | -11990 | gtex_brain_ba24 |
| rs7108426 | 11 | 67339522 | GSTP1 | ENSG00000084207.11 | 2.188E-8 | 0 | -11544 | gtex_brain_ba24 |
| rs7945927 | 11 | 67341600 | GSTP1 | ENSG00000084207.11 | 2.174E-8 | 0 | -9466 | gtex_brain_ba24 |
| rs6591249 | 11 | 67341658 | GSTP1 | ENSG00000084207.11 | 2.118E-8 | 0 | -9408 | gtex_brain_ba24 |
| rs7948911 | 11 | 67341779 | GSTP1 | ENSG00000084207.11 | 1.837E-8 | 0 | -9287 | gtex_brain_ba24 |
| rs4930444 | 11 | 67342580 | GSTP1 | ENSG00000084207.11 | 1.333E-9 | 0 | -8486 | gtex_brain_ba24 |
| rs656652 | 11 | 67343957 | GSTP1 | ENSG00000084207.11 | 4.141E-9 | 0 | -7109 | gtex_brain_ba24 |
| rs625978 | 11 | 67344664 | GSTP1 | ENSG00000084207.11 | 4.155E-9 | 0 | -6402 | gtex_brain_ba24 |
| rs6591251 | 11 | 67344689 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -6377 | gtex_brain_ba24 |
| rs6591252 | 11 | 67345577 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -5489 | gtex_brain_ba24 |
| rs597297 | 11 | 67346458 | GSTP1 | ENSG00000084207.11 | 1.369E-6 | 0 | -4608 | gtex_brain_ba24 |
| rs6591254 | 11 | 67346528 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -4538 | gtex_brain_ba24 |
| rs7940813 | 11 | 67346866 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -4200 | gtex_brain_ba24 |
| rs7927657 | 11 | 67346988 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -4078 | gtex_brain_ba24 |
| rs614080 | 11 | 67347287 | GSTP1 | ENSG00000084207.11 | 4.155E-9 | 0 | -3779 | gtex_brain_ba24 |
| rs7941395 | 11 | 67347417 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -3649 | gtex_brain_ba24 |
| rs7941648 | 11 | 67347595 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -3471 | gtex_brain_ba24 |
| rs7945035 | 11 | 67348162 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -2904 | gtex_brain_ba24 |
| rs2370141 | 11 | 67348529 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -2537 | gtex_brain_ba24 |
| rs2370142 | 11 | 67348642 | GSTP1 | ENSG00000084207.11 | 4.842E-9 | 0 | -2424 | gtex_brain_ba24 |
| rs7949394 | 11 | 67349320 | GSTP1 | ENSG00000084207.11 | 6.443E-9 | 0 | -1746 | gtex_brain_ba24 |
| rs7949587 | 11 | 67349347 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -1719 | gtex_brain_ba24 |
| rs6591255 | 11 | 67349548 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -1518 | gtex_brain_ba24 |
| rs6591256 | 11 | 67349899 | GSTP1 | ENSG00000084207.11 | 5.373E-9 | 0 | -1167 | gtex_brain_ba24 |
| rs694746 | 11 | 67350720 | GSTP1 | ENSG00000084207.11 | 5.02E-9 | 0 | -346 | gtex_brain_ba24 |
| rs17593068 | 11 | 67350932 | GSTP1 | ENSG00000084207.11 | 3.278E-9 | 0 | -134 | gtex_brain_ba24 |
| rs370946317 | 11 | 67350996 | GSTP1 | ENSG00000084207.11 | 1.518E-7 | 0 | -70 | gtex_brain_ba24 |
| rs201598223 | 11 | 67350998 | GSTP1 | ENSG00000084207.11 | 1.429E-7 | 0 | -68 | gtex_brain_ba24 |
| rs36211089 | 11 | 67351004 | GSTP1 | ENSG00000084207.11 | 1.428E-7 | 0 | -62 | gtex_brain_ba24 |
| rs8191443 | 11 | 67351529 | GSTP1 | ENSG00000084207.11 | 1.426E-9 | 0 | 463 | gtex_brain_ba24 |
| rs1079719 | 11 | 67351531 | GSTP1 | ENSG00000084207.11 | 4.459E-9 | 0 | 465 | gtex_brain_ba24 |
| rs4147581 | 11 | 67351585 | GSTP1 | ENSG00000084207.11 | 1.786E-9 | 0 | 519 | gtex_brain_ba24 |
| rs2370143 | 11 | 67351774 | GSTP1 | ENSG00000084207.11 | 5.746E-9 | 0 | 708 | gtex_brain_ba24 |
| rs762803 | 11 | 67352256 | GSTP1 | ENSG00000084207.11 | 7.63E-9 | 0 | 1190 | gtex_brain_ba24 |
| rs1695 | 11 | 67352689 | GSTP1 | ENSG00000084207.11 | 2.319E-7 | 0 | 1623 | gtex_brain_ba24 |
| rs749174 | 11 | 67353253 | GSTP1 | ENSG00000084207.11 | 1.002E-6 | 0 | 2187 | gtex_brain_ba24 |
| rs1871042 | 11 | 67353844 | GSTP1 | ENSG00000084207.11 | 1.662E-6 | 0 | 2778 | gtex_brain_ba24 |
| rs4891 | 11 | 67353970 | GSTP1 | ENSG00000084207.11 | 6.618E-7 | 0 | 2904 | gtex_brain_ba24 |
| rs947895 | 11 | 67354406 | GSTP1 | ENSG00000084207.11 | 1.669E-6 | 0 | 3340 | gtex_brain_ba24 |
| rs640777 | 11 | 67354986 | GSTP1 | ENSG00000084207.11 | 5.771E-9 | 0 | 3920 | gtex_brain_ba24 |
| rs6591258 | 11 | 67355804 | GSTP1 | ENSG00000084207.11 | 6.592E-7 | 0 | 4738 | gtex_brain_ba24 |
| rs7104580 | 11 | 67356002 | GSTP1 | ENSG00000084207.11 | 4.334E-7 | 0 | 4936 | gtex_brain_ba24 |
| rs11603735 | 11 | 67356709 | GSTP1 | ENSG00000084207.11 | 4.279E-7 | 0 | 5643 | gtex_brain_ba24 |
| rs4360710 | 11 | 67358076 | GSTP1 | ENSG00000084207.11 | 8.664E-8 | 0 | 7010 | gtex_brain_ba24 |
| rs7939505 | 11 | 67359090 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 8024 | gtex_brain_ba24 |
| rs596603 | 11 | 67359603 | GSTP1 | ENSG00000084207.11 | 9.45E-9 | 0 | 8537 | gtex_brain_ba24 |
| rs6591259 | 11 | 67359718 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 8652 | gtex_brain_ba24 |
| rs7937159 | 11 | 67359947 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 8881 | gtex_brain_ba24 |
| rs7950707 | 11 | 67360101 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 9035 | gtex_brain_ba24 |
| rs4244823 | 11 | 67361356 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 10290 | gtex_brain_ba24 |
| rs11227845 | 11 | 67361567 | GSTP1 | ENSG00000084207.11 | 4.592E-8 | 0 | 10501 | gtex_brain_ba24 |
| rs7108149 | 11 | 67362363 | GSTP1 | ENSG00000084207.11 | 1.716E-6 | 0 | 11297 | gtex_brain_ba24 |
| rs7108038 | 11 | 67362385 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 11319 | gtex_brain_ba24 |
| rs12416994 | 11 | 67366475 | GSTP1 | ENSG00000084207.11 | 1.281E-7 | 0 | 15409 | gtex_brain_ba24 |
| rs10896185 | 11 | 67367108 | GSTP1 | ENSG00000084207.11 | 9.414E-9 | 0 | 16042 | gtex_brain_ba24 |
| rs11603991 | 11 | 67367922 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 16856 | gtex_brain_ba24 |
| rs7103632 | 11 | 67368443 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 17377 | gtex_brain_ba24 |
| rs12790798 | 11 | 67368641 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 17575 | gtex_brain_ba24 |
| rs12792496 | 11 | 67368687 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 17621 | gtex_brain_ba24 |
| rs12798262 | 11 | 67369065 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 17999 | gtex_brain_ba24 |
| rs10896186 | 11 | 67369670 | GSTP1 | ENSG00000084207.11 | 1.054E-8 | 0 | 18604 | gtex_brain_ba24 |
| rs4930450 | 11 | 67369986 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 18920 | gtex_brain_ba24 |
| rs4024254 | 11 | 67370766 | GSTP1 | ENSG00000084207.11 | 4.891E-8 | 0 | 19700 | gtex_brain_ba24 |
| rs12421329 | 11 | 67372477 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 21411 | gtex_brain_ba24 |
| rs12793832 | 11 | 67372593 | GSTP1 | ENSG00000084207.11 | 4.914E-7 | 0 | 21527 | gtex_brain_ba24 |
| rs1871043 | 11 | 67374581 | GSTP1 | ENSG00000084207.11 | 4.88E-8 | 0 | 23515 | gtex_brain_ba24 |
| rs7948073 | 11 | 67375184 | GSTP1 | ENSG00000084207.11 | 7.092E-9 | 0 | 24118 | gtex_brain_ba24 |
| rs4148959 | 11 | 67381110 | GSTP1 | ENSG00000084207.11 | 7.049E-9 | 0 | 30044 | gtex_brain_ba24 |
| rs4148960 | 11 | 67381657 | GSTP1 | ENSG00000084207.11 | 7.054E-9 | 0 | 30591 | gtex_brain_ba24 |
| rs36026034 | 11 | 67382227 | GSTP1 | ENSG00000084207.11 | 8.452E-9 | 0 | 31161 | gtex_brain_ba24 |
| rs56092845 | 11 | 67383557 | GSTP1 | ENSG00000084207.11 | 1.051E-8 | 0 | 32491 | gtex_brain_ba24 |
| rs7130679 | 11 | 67385125 | GSTP1 | ENSG00000084207.11 | 1.011E-7 | 0 | 34059 | gtex_brain_ba24 |
| rs2447596 | 11 | 67385261 | GSTP1 | ENSG00000084207.11 | 7.092E-9 | 0 | 34195 | gtex_brain_ba24 |
| rs2447595 | 11 | 67385544 | GSTP1 | ENSG00000084207.11 | 7.092E-9 | 0 | 34478 | gtex_brain_ba24 |
| rs11227862 | 11 | 67386311 | GSTP1 | ENSG00000084207.11 | 7.092E-9 | 0 | 35245 | gtex_brain_ba24 |
| rs2126717 | 11 | 67388852 | GSTP1 | ENSG00000084207.11 | 9.239E-9 | 0 | 37786 | gtex_brain_ba24 |
| rs2126718 | 11 | 67389129 | GSTP1 | ENSG00000084207.11 | 1.142E-8 | 0 | 38063 | gtex_brain_ba24 |
| rs2187002 | 11 | 67389532 | GSTP1 | ENSG00000084207.11 | 7.092E-9 | 0 | 38466 | gtex_brain_ba24 |
| rs2126719 | 11 | 67390240 | GSTP1 | ENSG00000084207.11 | 1.238E-8 | 0 | 39174 | gtex_brain_ba24 |
| rs11227866 | 11 | 67390710 | GSTP1 | ENSG00000084207.11 | 1.443E-8 | 0 | 39644 | gtex_brain_ba24 |
| rs61894496 | 11 | 67391907 | GSTP1 | ENSG00000084207.11 | 5.452E-9 | 0 | 40841 | gtex_brain_ba24 |
| rs10791908 | 11 | 67392813 | GSTP1 | ENSG00000084207.11 | 6.558E-8 | 0 | 41747 | gtex_brain_ba24 |
| rs2514017 | 11 | 67393734 | GSTP1 | ENSG00000084207.11 | 9.501E-9 | 0 | 42668 | gtex_brain_ba24 |
| rs78371233 | 11 | 67397668 | GSTP1 | ENSG00000084207.11 | 1.031E-8 | 0 | 46602 | gtex_brain_ba24 |
| rs1531514 | 11 | 67398862 | GSTP1 | ENSG00000084207.11 | 5.452E-9 | 0 | 47796 | gtex_brain_ba24 |
| rs3765088 | 11 | 67399970 | GSTP1 | ENSG00000084207.11 | 7.495E-9 | 0 | 48904 | gtex_brain_ba24 |
| rs2514022 | 11 | 67402113 | GSTP1 | ENSG00000084207.11 | 4.132E-8 | 0 | 51047 | gtex_brain_ba24 |
| rs2509709 | 11 | 67403075 | GSTP1 | ENSG00000084207.11 | 3.918E-8 | 0 | 52009 | gtex_brain_ba24 |
| rs149026237 | 11 | 67404001 | GSTP1 | ENSG00000084207.11 | 8.688E-7 | 0 | 52935 | gtex_brain_ba24 |
| rs4930210 | 11 | 67404726 | GSTP1 | ENSG00000084207.11 | 4.649E-8 | 0 | 53660 | gtex_brain_ba24 |
| rs10896190 | 11 | 67406123 | GSTP1 | ENSG00000084207.11 | 8.223E-9 | 0 | 55057 | gtex_brain_ba24 |
| rs7948911 | 11 | 67341779 | GSTP1 | ENSG00000084207.11 | 3.547E-6 | 0.04 | -9287 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C17orf80 | 0.88 | 0.89 |
| MAP3K7 | 0.88 | 0.88 |
| SAR1A | 0.87 | 0.87 |
| ZC3H14 | 0.87 | 0.86 |
| MAP3K7IP2 | 0.87 | 0.86 |
| EIF2AK1 | 0.87 | 0.84 |
| SMU1 | 0.87 | 0.84 |
| TSN | 0.87 | 0.84 |
| YME1L1 | 0.87 | 0.87 |
| DCLRE1A | 0.86 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.75 | -0.74 |
| AF347015.31 | -0.74 | -0.73 |
| AF347015.21 | -0.72 | -0.71 |
| MT-CYB | -0.72 | -0.72 |
| AF347015.8 | -0.71 | -0.72 |
| HIGD1B | -0.71 | -0.72 |
| IFI27 | -0.70 | -0.73 |
| AF347015.33 | -0.69 | -0.69 |
| AF347015.2 | -0.69 | -0.68 |
| FXYD1 | -0.68 | -0.71 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16636664 | |
| GO:0004364 | glutathione transferase activity | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007417 | central nervous system development | TAS | Brain (GO term level: 6) | 9802272 |
| GO:0008152 | metabolic process | IEA | - | |
| GO:0006916 | anti-apoptosis | TAS | 16130169 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | TAS | 16130169 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLUTATHIONE METABOLISM | 50 | 34 | All SZGR 2.0 genes in this pathway |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG PROSTATE CANCER | 89 | 75 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUTATHIONE CONJUGATION | 23 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE II CONJUGATION | 70 | 42 | All SZGR 2.0 genes in this pathway |
| WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN | 92 | 51 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| TIMOFEEVA GROWTH STRESS VIA STAT1 DN | 16 | 12 | All SZGR 2.0 genes in this pathway |
| BASAKI YBX1 TARGETS UP | 290 | 177 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP DN | 35 | 20 | All SZGR 2.0 genes in this pathway |
| LI LUNG CANCER | 41 | 30 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| YANG BREAST CANCER ESR1 LASER DN | 50 | 38 | All SZGR 2.0 genes in this pathway |
| OHM METHYLATED IN ADULT CANCERS | 27 | 23 | All SZGR 2.0 genes in this pathway |
| OHM EMBRYONIC CARCINOMA UP | 6 | 5 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| RAHMAN TP53 TARGETS PHOSPHORYLATED | 21 | 18 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC TARGETS WITH EBOX | 230 | 156 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON | 158 | 93 | All SZGR 2.0 genes in this pathway |
| KLEIN PRIMARY EFFUSION LYMPHOMA DN | 58 | 42 | All SZGR 2.0 genes in this pathway |
| CHEN LUNG CANCER SURVIVAL | 28 | 22 | All SZGR 2.0 genes in this pathway |
| FERNANDEZ BOUND BY MYC | 182 | 116 | All SZGR 2.0 genes in this pathway |
| XU RESPONSE TO TRETINOIN AND NSC682994 UP | 17 | 13 | All SZGR 2.0 genes in this pathway |
| LEI MYB TARGETS | 318 | 215 | All SZGR 2.0 genes in this pathway |
| CROMER METASTASIS DN | 81 | 58 | All SZGR 2.0 genes in this pathway |
| KAAB FAILED HEART ATRIUM DN | 141 | 99 | All SZGR 2.0 genes in this pathway |
| NATSUME RESPONSE TO INTERFERON BETA DN | 52 | 33 | All SZGR 2.0 genes in this pathway |
| ZHANG PROLIFERATING VS QUIESCENT | 51 | 41 | All SZGR 2.0 genes in this pathway |
| JOSEPH RESPONSE TO SODIUM BUTYRATE UP | 31 | 21 | All SZGR 2.0 genes in this pathway |
| ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST | 132 | 93 | All SZGR 2.0 genes in this pathway |
| LOPES METHYLATED IN COLON CANCER DN | 28 | 26 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| HOQUE METHYLATED IN CANCER | 56 | 45 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
| HONMA DOCETAXEL RESISTANCE | 34 | 23 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
| LI PROSTATE CANCER EPIGENETIC | 30 | 22 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S1 | 237 | 159 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | All SZGR 2.0 genes in this pathway |
| PASINI SUZ12 TARGETS UP | 112 | 65 | All SZGR 2.0 genes in this pathway |