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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: CNOT7

Summary

GeneID

29883

Symbol

CNOT7

Synonyms

CAF1|hCAF-1

Description

CCR4-NOT transcription complex, subunit 7

Locus tag

Gene type

protein-coding

Map location

8p22-p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.03086

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.00057

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004871

signal transducer activity

TAS

9820826

GO:0003676

nucleic acid binding

IEA

GO:0003700

transcription factor activity

TAS

9820826

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

9820826

GO:0016563

transcription activator activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0005975

carbohydrate metabolic process

TAS

9820826

GO:0007165

signal transduction

TAS

9820826

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

9820826

GO:0005634

nucleus

IEA

GO:0030014

CCR4-NOT complex

IEA

GO:0030014

CCR4-NOT complex

NAS

9820826

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BTG1	-	B-cell translocation gene 1, anti-proliferative	-	HPRD,BioGRID	9820826 \|11136725 \|11429045
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	Reconstituted Complex	BioGRID	11136725
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	-	HPRD	9712883
BTG3	ANA \| MGC8928 \| TOB5 \| TOB55 \| TOFA	BTG family, member 3	-	HPRD	11429045
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD,BioGRID	10602502
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	10602502
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD,BioGRID	10602502
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	10602502
CNOT6	CCR4 \| KIAA1194	CCR4-NOT transcription complex, subunit 6	-	HPRD	10637334
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-Western Reconstituted Complex	BioGRID	18056425
TOB1	APRO6 \| MGC104792 \| MGC34446 \| PIG49 \| TOB \| TROB \| TROB1	transducer of ERBB2, 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10602502 \|18056425
TOB2	TOB4 \| TOBL \| TROB2	transducer of ERBB2, 2	-	HPRD,BioGRID	10602502

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_RNA_DEGRADATION	59	37	All SZGR genes in this pathway
REACTOME_DEADENYLATION_OF_MRNA	22	14	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA	284	128	All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	48	29	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA	330	155	All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP	201	125	All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP	94	59	All SZGR genes in this pathway
GARY_CD5_TARGETS_DN	431	263	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN	320	184	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_6HR	40	23	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	514	319	All SZGR genes in this pathway
GROSS_ELK3_TARGETS_DN	32	17	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP	142	104	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN	176	104	All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN	64	47	All SZGR genes in this pathway
MOOTHA_VOXPHOS	87	51	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP	89	51	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP	83	66	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	953	554	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP	783	442	All SZGR genes in this pathway
MATZUK_SPERMATOCYTE	72	55	All SZGR genes in this pathway
MATZUK_SPERMATOZOA	114	77	All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE	242	168	All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002	429	260	All SZGR genes in this pathway
MOOTHA_PGC	420	269	All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA	447	277	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2	277	172	All SZGR genes in this pathway
CARD_MIR302A_TARGETS	77	62	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN	553	343	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	209	215	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-128	1175	1181	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1175	1181	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	424	430	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-136	1032	1039	1A,m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-17-5p/20/93.mr/106/519.d	426	433	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-19	423	429	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	423	429	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	517	523	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-27	1175	1182	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1175	1182	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-320	721	728	1A,m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-363	557	563	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-377	239	245	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	43	50	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	1154	1160	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-490	196	202	1A	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-544	1194	1200	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	947	953	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.