SZGR2

Summary ?

GeneID	29883
Symbol	CNOT7
Synonyms	CAF1\|Caf1a\|hCAF-1
Description	CCR4-NOT transcription complex subunit 7
Reference	MIM:604913\|HGNC:HGNC:14101\|Ensembl:ENSG00000198791\|Vega:OTTHUMG00000096971
Gene type	protein-coding
Map location	8p22-p21.3
Pascal p-value	1.56E-6
Sherlock p-value	0.241
eGene	Cerebellum Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_I	Genome scan meta-analysis	Psr: 0.031
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.03086
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.00057

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg17548406	8	17104535	VPS37A;CNOT7	4.33E-4	-0.372	0.045	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	TAS		9820826
GO:0003676	nucleic acid binding	IEA		-
GO:0003700	transcription factor activity	TAS		9820826
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		9820826
GO:0016563	transcription activator activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0005975	carbohydrate metabolic process	TAS		9820826
GO:0007165	signal transduction	TAS		9820826
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IDA		9820826
GO:0005634	nucleus	IEA		-
GO:0030014	CCR4-NOT complex	IEA		-
GO:0030014	CCR4-NOT complex	NAS		9820826

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BTG1	-	B-cell translocation gene 1, anti-proliferative	-	HPRD,BioGRID	9820826 \|11136725 \|11429045
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	Reconstituted Complex	BioGRID	11136725
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	-	HPRD	9712883
BTG3	ANA \| MGC8928 \| TOB5 \| TOB55 \| TOFA	BTG family, member 3	-	HPRD	11429045
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD,BioGRID	10602502
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	10602502
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD,BioGRID	10602502
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	10602502
CNOT6	CCR4 \| KIAA1194	CCR4-NOT transcription complex, subunit 6	-	HPRD	10637334
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-Western Reconstituted Complex	BioGRID	18056425
TOB1	APRO6 \| MGC104792 \| MGC34446 \| PIG49 \| TOB \| TROB \| TROB1	transducer of ERBB2, 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10602502 \|18056425
TOB2	TOB4 \| TOBL \| TROB2	transducer of ERBB2, 2	-	HPRD,BioGRID	10602502

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RNA DEGRADATION	59	37	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION OF MRNA	22	14	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP	94	59	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 6HR	40	23	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN	32	17	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN	176	104	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS	87	51	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP	89	51	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP	83	66	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE	72	55	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA	114	77	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	209	215	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-128	1175	1181	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1175	1181	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	424	430	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-136	1032	1039	1A,m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-17-5p/20/93.mr/106/519.d	426	433	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-19	423	429	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	423	429	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	517	523	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-27	1175	1182	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1175	1182	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-320	721	728	1A,m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-363	557	563	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-377	239	245	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	43	50	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	1154	1160	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-490	196	202	1A	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-544	1194	1200	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	947	953	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CNOT7