Gene Page: HCK
Summary ?
| GeneID | 3055 |
| Symbol | HCK |
| Synonyms | JTK9|p59Hck|p61Hck |
| Description | HCK proto-oncogene, Src family tyrosine kinase |
| Reference | MIM:142370|HGNC:HGNC:4840|Ensembl:ENSG00000101336|HPRD:00796|Vega:OTTHUMG00000032204 |
| Gene type | protein-coding |
| Map location | 20q11-q12 |
| Pascal p-value | 0.01 |
| eGene | Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.1626 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12624267 | chr2 | 73986930 | HCK | 3055 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NDUFA9 | 0.85 | 0.76 |
| C20orf30 | 0.83 | 0.79 |
| APOA1BP | 0.82 | 0.73 |
| TSPAN31 | 0.82 | 0.65 |
| TRUB2 | 0.82 | 0.71 |
| SDHB | 0.82 | 0.72 |
| CYC1 | 0.81 | 0.67 |
| C1orf102 | 0.80 | 0.73 |
| ECHS1 | 0.80 | 0.75 |
| METTL1 | 0.80 | 0.76 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EIF5B | -0.42 | -0.49 |
| ANP32C | -0.38 | -0.46 |
| AF347015.18 | -0.36 | -0.28 |
| AC010300.1 | -0.36 | -0.44 |
| AC005921.3 | -0.33 | -0.49 |
| MAP4K4 | -0.31 | -0.29 |
| ZNF326 | -0.30 | -0.25 |
| AC100783.1 | -0.30 | -0.26 |
| ZC3H13 | -0.29 | -0.21 |
| THOC2 | -0.29 | -0.28 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 7859737 |12029088 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006468 | protein amino acid phosphorylation | TAS | 3496523 | |
| GO:0007498 | mesoderm development | TAS | 3453117 | |
| GO:0044419 | interspecies interaction between organisms | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0016020 | membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD,BioGRID | 9407116 |
| ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | - | HPRD | 12748290 |
| ADAM15 | MDC15 | ADAM metallopeptidase domain 15 | - | HPRD,BioGRID | 11741929 |
| BCAR1 | CAS | CAS1 | CASS1 | CRKAS | P130Cas | breast cancer anti-estrogen resistance 1 | - | HPRD,BioGRID | 9020138 |
| BCR | ALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHL | breakpoint cluster region | Affinity Capture-Western | BioGRID | 10849448 |12592324 |
| BTK | AGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLA | Bruton agammaglobulinemia tyrosine kinase | - | HPRD,BioGRID | 8058772 |
| C14orf4 | EAP1 | IRF2BPL | KIAA1865 | chromosome 14 open reading frame 4 | - | HPRD | 12029088 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | - | HPRD,BioGRID | 10092522 |
| CCR3 | CC-CKR-3 | CD193 | CKR3 | CMKBR3 | MGC102841 | chemokine (C-C motif) receptor 3 | - | HPRD,BioGRID | 10527858 |
| CSF3R | CD114 | GCSFR | colony stimulating factor 3 receptor (granulocyte) | - | HPRD,BioGRID | 9790917 |
| DOK1 | MGC117395 | MGC138860 | P62DOK | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | Reconstituted Complex | BioGRID | 11071635 |
| ELMO1 | CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406 | engulfment and cell motility 1 | - | HPRD,BioGRID | 12029088 |
| EVL | RNB6 | Enah/Vasp-like | - | HPRD | 12029088 |
| FCGR1A | CD64 | CD64A | FCRI | FLJ18345 | IGFR1 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | - | HPRD,BioGRID | 8064233 |
| FCGR2A | CD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | - | HPRD | 9268059 |
| GALNAC4S-6ST | BRAG | DKFZp781H1369 | KIAA0598 | MGC34346 | RP11-47G11.1 | B cell RAG associated protein | - | HPRD,BioGRID | 10749872 |
| IL6ST | CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta | interleukin 6 signal transducer (gp130, oncostatin M receptor) | - | HPRD,BioGRID | 11689697 |
| KHDRBS1 | FLJ34027 | Sam68 | p62 | KH domain containing, RNA binding, signal transduction associated 1 | Hck interacts with Sam68. | BIND | 11278465 |
| PECAM1 | CD31 | PECAM-1 | platelet/endothelial cell adhesion molecule | - | HPRD,BioGRID | 10858437 |
| PLAUR | CD87 | UPAR | URKR | plasminogen activator, urokinase receptor | - | HPRD,BioGRID | 11097855 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD | 10586033 |
| RAPGEF1 | C3G | DKFZp781P1719 | GRF2 | Rap guanine nucleotide exchange factor (GEF) 1 | - | HPRD,BioGRID | 14551197 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | - | HPRD,BioGRID | 7782336 |
| RASA3 | GAP1IP4BP | GAPIII | MGC46517 | MGC47588 | RAS p21 protein activator 3 | - | HPRD,BioGRID | 7782336 |
| RPL10 | DKFZp686J1851 | DXS648 | DXS648E | FLJ23544 | FLJ27072 | NOV | QM | ribosomal protein L10 | Reconstituted Complex | BioGRID | 12138090 |
| SH3BP1 | - | SH3-domain binding protein 1 | - | HPRD | 12029088 |
| SKAP2 | MGC10411 | MGC33304 | PRAP | RA70 | SAPS | SCAP2 | SKAP-HOM | SKAP55R | src kinase associated phosphoprotein 2 | - | HPRD,BioGRID | 9837776 |
| TRPV4 | OTRPC4 | TRP12 | VR-OAC | VRL-2 | VRL2 | VROAC | transient receptor potential cation channel, subfamily V, member 4 | - | HPRD,BioGRID | 12538589 |
| UNC119 | HRG4 | unc-119 homolog (C. elegans) | - | HPRD,BioGRID | 12496276 |
| WAS | IMD2 | THC | WASP | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | Reconstituted Complex | BioGRID | 12029088 |
| WIPF1 | MGC111041 | PRPL-2 | WASPIP | WIP | WAS/WASL interacting protein family, member 1 | - | HPRD,BioGRID | 12029088 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | All SZGR 2.0 genes in this pathway |
| BIOCARTA BARRESTIN SRC PATHWAY | 15 | 14 | All SZGR 2.0 genes in this pathway |
| PID GLYPICAN 1PATHWAY | 27 | 20 | All SZGR 2.0 genes in this pathway |
| PID PTP1B PATHWAY | 52 | 40 | All SZGR 2.0 genes in this pathway |
| PID P38 ALPHA BETA PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
| PID TXA2PATHWAY | 57 | 43 | All SZGR 2.0 genes in this pathway |
| PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
| PID PI3KCI PATHWAY | 49 | 40 | All SZGR 2.0 genes in this pathway |
| PID AMB2 NEUTROPHILS PATHWAY | 41 | 32 | All SZGR 2.0 genes in this pathway |
| PID EPHA FWDPATHWAY | 34 | 29 | All SZGR 2.0 genes in this pathway |
| PID IL6 7 PATHWAY | 47 | 40 | All SZGR 2.0 genes in this pathway |
| PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
| PID IL8 CXCR2 PATHWAY | 34 | 26 | All SZGR 2.0 genes in this pathway |
| PID IL8 CXCR1 PATHWAY | 28 | 19 | All SZGR 2.0 genes in this pathway |
| PID EPHRINB REV PATHWAY | 30 | 25 | All SZGR 2.0 genes in this pathway |
| PID ALPHA SYNUCLEIN PATHWAY | 33 | 25 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF SIGNALING BY CBL | 18 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 43 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
| SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP | 158 | 103 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| LI LUNG CANCER | 41 | 30 | All SZGR 2.0 genes in this pathway |
| KHETCHOUMIAN TRIM24 TARGETS UP | 47 | 38 | All SZGR 2.0 genes in this pathway |
| GROSS ELK3 TARGETS UP | 27 | 16 | All SZGR 2.0 genes in this pathway |
| MORI IMMATURE B LYMPHOCYTE UP | 53 | 35 | All SZGR 2.0 genes in this pathway |
| BROCKE APOPTOSIS REVERSED BY IL6 | 144 | 98 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP | 45 | 30 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT UP | 165 | 100 | All SZGR 2.0 genes in this pathway |
| NEMETH INFLAMMATORY RESPONSE LPS UP | 88 | 64 | All SZGR 2.0 genes in this pathway |
| HESS TARGETS OF HOXA9 AND MEIS1 DN | 77 | 48 | All SZGR 2.0 genes in this pathway |
| VERHAAK AML WITH NPM1 MUTATED UP | 183 | 111 | All SZGR 2.0 genes in this pathway |
| HADDAD T LYMPHOCYTE AND NK PROGENITOR DN | 63 | 41 | All SZGR 2.0 genes in this pathway |
| NOUZOVA TRETINOIN AND H4 ACETYLATION | 143 | 85 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES DN | 245 | 144 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES UP | 253 | 147 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| FINETTI BREAST CANCER KINOME GREEN | 16 | 14 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS DN | 145 | 93 | All SZGR 2.0 genes in this pathway |
| BHATI G2M ARREST BY 2METHOXYESTRADIOL UP | 125 | 68 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN | 40 | 31 | All SZGR 2.0 genes in this pathway |
| ICHIBA GRAFT VERSUS HOST DISEASE D7 UP | 107 | 67 | All SZGR 2.0 genes in this pathway |
| ICHIBA GRAFT VERSUS HOST DISEASE 35D UP | 131 | 79 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN | 72 | 47 | All SZGR 2.0 genes in this pathway |
| HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN | 50 | 36 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K27ME3 | 79 | 59 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 | 59 | 35 | All SZGR 2.0 genes in this pathway |
| GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN | 9 | 7 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| NAKAMURA ADIPOGENESIS EARLY DN | 38 | 27 | All SZGR 2.0 genes in this pathway |
| NAKAMURA ADIPOGENESIS LATE DN | 38 | 25 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| MADAN DPPA4 TARGETS | 46 | 26 | All SZGR 2.0 genes in this pathway |
| PLASARI TGFB1 TARGETS 10HR UP | 199 | 143 | All SZGR 2.0 genes in this pathway |