Summary ?
GeneID3073
SymbolHEXA
SynonymsTSD
Descriptionhexosaminidase subunit alpha
ReferenceMIM:606869|HGNC:HGNC:4878|HPRD:06040|
Gene typeprotein-coding
Map location15q24.1
Pascal p-value0.083
eGeneCaudate basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs928641chr9119927509HEXA30730.19trans
snp_a-22310550HEXA30730.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NCBP10.960.95
WDR30.950.95
PAPOLG0.950.95
ZMYM40.950.95
KIAA14290.950.95
CAPRIN10.950.95
XRCC50.950.96
SMEK20.950.95
TAF20.950.95
EPRS0.950.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.72-0.86
AF347015.31-0.71-0.85
IFI27-0.71-0.85
FXYD1-0.71-0.84
HLA-F-0.70-0.76
AF347015.33-0.70-0.83
AF347015.27-0.69-0.81
C5orf53-0.69-0.71
AC018755.7-0.68-0.73
MT-CYB-0.68-0.82

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004563beta-N-acetylhexosaminidase activityIEA-
GO:0016798hydrolase activity, acting on glycosyl bondsIEA-
GO:0043169cation bindingIEA-
GO:0046982protein heterodimerization activityIDA6230359 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042552myelinationIEAneuron, axon, Brain, oligodendrocyte (GO term level: 13)-
GO:0001501skeletal system developmentIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0008152metabolic processIEA-
GO:0019953sexual reproductionIEA-
GO:0007628adult walking behaviorIEA-
GO:0007626locomotory behaviorIEA-
GO:0007605sensory perception of soundIEA-
GO:0019915sequestering of lipidIEA-
GO:0007040lysosome organizationIEA-
GO:0006689ganglioside catabolic processIEA-
GO:0030203glycosaminoglycan metabolic processIEA-
GO:0050885neuromuscular process controlling balanceIEA-
GO:0050884neuromuscular process controlling postureIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005764lysosomeIEA-
GO:0016020membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OTHER GLYCAN DEGRADATION 1612All SZGR 2.0 genes in this pathway
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 4430All SZGR 2.0 genes in this pathway
KEGG GLYCOSAMINOGLYCAN DEGRADATION 2114All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GLOBO SERIES 1412All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GANGLIO SERIES 159All SZGR 2.0 genes in this pathway
KEGG LYSOSOME 12183All SZGR 2.0 genes in this pathway
REACTOME GLYCOSPHINGOLIPID METABOLISM 3822All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME CS DS DEGRADATION 129All SZGR 2.0 genes in this pathway
REACTOME HYALURONAN UPTAKE AND DEGRADATION 107All SZGR 2.0 genes in this pathway
REACTOME HYALURONAN METABOLISM 147All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 4933All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE KERATIN METABOLISM 3021All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE DEGRADATION 117All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 11169All SZGR 2.0 genes in this pathway
REACTOME SPHINGOLIPID METABOLISM 6940All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247154All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 1914All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 4936All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE 3322All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 10871All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 4533All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 7447All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 7561All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 6543All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway