Gene Page: ZNRD1
Summary ?
| GeneID | 30834 |
| Symbol | ZNRD1 |
| Synonyms | HTEX-6|HTEX6|Rpa12|TCTEX6|TEX6|ZR14|hZR14|tctex-6 |
| Description | zinc ribbon domain containing 1 |
| Reference | MIM:607525|HGNC:HGNC:13182|Ensembl:ENSG00000066379|HPRD:09601|Vega:OTTHUMG00000031149 |
| Gene type | protein-coding |
| Map location | 6p21.3 |
| Pascal p-value | 5.24E-14 |
| Fetal beta | 0.7 |
| eGene | Hippocampus Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWAScat | Genome-wide Association Studies | This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb. | |
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs757257 | 6 | 30142458 | ZNRD1 | ENSG00000066379.10 | 2.167E-6 | 0 | 113427 | gtex_brain_putamen_basal |
| rs2394737 | 6 | 30142999 | ZNRD1 | ENSG00000066379.10 | 7.743E-8 | 0 | 113968 | gtex_brain_putamen_basal |
| rs2844786 | 6 | 30144420 | ZNRD1 | ENSG00000066379.10 | 2.097E-7 | 0 | 115389 | gtex_brain_putamen_basal |
| rs9261539 | 6 | 30145083 | ZNRD1 | ENSG00000066379.10 | 7.743E-8 | 0 | 116052 | gtex_brain_putamen_basal |
| rs7774730 | 6 | 30145740 | ZNRD1 | ENSG00000066379.10 | 7.743E-8 | 0 | 116709 | gtex_brain_putamen_basal |
| rs9261543 | 6 | 30146650 | ZNRD1 | ENSG00000066379.10 | 7.743E-8 | 0 | 117619 | gtex_brain_putamen_basal |
| rs2508029 | 6 | 30146733 | ZNRD1 | ENSG00000066379.10 | 2.097E-7 | 0 | 117702 | gtex_brain_putamen_basal |
| rs7763162 | 6 | 30147356 | ZNRD1 | ENSG00000066379.10 | 2.167E-6 | 0 | 118325 | gtex_brain_putamen_basal |
| rs9261546 | 6 | 30148461 | ZNRD1 | ENSG00000066379.10 | 2.007E-6 | 0 | 119430 | gtex_brain_putamen_basal |
| rs2107196 | 6 | 30149251 | ZNRD1 | ENSG00000066379.10 | 2.088E-7 | 0 | 120220 | gtex_brain_putamen_basal |
| rs2844782 | 6 | 30150043 | ZNRD1 | ENSG00000066379.10 | 7.516E-8 | 0 | 121012 | gtex_brain_putamen_basal |
| rs2074473 | 6 | 30154199 | ZNRD1 | ENSG00000066379.10 | 1.708E-6 | 0 | 125168 | gtex_brain_putamen_basal |
| rs6457164 | 6 | 30155108 | ZNRD1 | ENSG00000066379.10 | 3.936E-7 | 0 | 126077 | gtex_brain_putamen_basal |
| rs6457165 | 6 | 30155131 | ZNRD1 | ENSG00000066379.10 | 2.896E-7 | 0 | 126100 | gtex_brain_putamen_basal |
| rs6457167 | 6 | 30155313 | ZNRD1 | ENSG00000066379.10 | 3.936E-7 | 0 | 126282 | gtex_brain_putamen_basal |
| rs28441239 | 6 | 30156015 | ZNRD1 | ENSG00000066379.10 | 2.283E-7 | 0 | 126984 | gtex_brain_putamen_basal |
| rs2074472 | 6 | 30156496 | ZNRD1 | ENSG00000066379.10 | 2.655E-7 | 0 | 127465 | gtex_brain_putamen_basal |
| rs561902625 | 6 | 30157599 | ZNRD1 | ENSG00000066379.10 | 2.926E-7 | 0 | 128568 | gtex_brain_putamen_basal |
| rs765977 | 6 | 30157654 | ZNRD1 | ENSG00000066379.10 | 3.936E-7 | 0 | 128623 | gtex_brain_putamen_basal |
| rs718254 | 6 | 30159039 | ZNRD1 | ENSG00000066379.10 | 2.754E-7 | 0 | 130008 | gtex_brain_putamen_basal |
| rs2284164 | 6 | 30159854 | ZNRD1 | ENSG00000066379.10 | 3.732E-8 | 0 | 130823 | gtex_brain_putamen_basal |
| rs9261548 | 6 | 30160877 | ZNRD1 | ENSG00000066379.10 | 2.158E-6 | 0 | 131846 | gtex_brain_putamen_basal |
| rs7382110 | 6 | 30161205 | ZNRD1 | ENSG00000066379.10 | 7.889E-9 | 0 | 132174 | gtex_brain_putamen_basal |
| rs7383511 | 6 | 30161509 | ZNRD1 | ENSG00000066379.10 | 1.649E-7 | 0 | 132478 | gtex_brain_putamen_basal |
| rs3132672 | 6 | 30175847 | ZNRD1 | ENSG00000066379.10 | 4.491E-8 | 0 | 146816 | gtex_brain_putamen_basal |
| rs553613810 | 6 | 30176311 | ZNRD1 | ENSG00000066379.10 | 9.859E-10 | 0 | 147280 | gtex_brain_putamen_basal |
| rs3130381 | 6 | 30177860 | ZNRD1 | ENSG00000066379.10 | 5.786E-8 | 0 | 148829 | gtex_brain_putamen_basal |
| rs3130382 | 6 | 30177917 | ZNRD1 | ENSG00000066379.10 | 7.348E-8 | 0 | 148886 | gtex_brain_putamen_basal |
| rs3132671 | 6 | 30178287 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 149256 | gtex_brain_putamen_basal |
| rs3130383 | 6 | 30179026 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 149995 | gtex_brain_putamen_basal |
| rs3130384 | 6 | 30179152 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 150121 | gtex_brain_putamen_basal |
| rs3130386 | 6 | 30180246 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 151215 | gtex_brain_putamen_basal |
| rs3094615 | 6 | 30181117 | ZNRD1 | ENSG00000066379.10 | 5.79E-8 | 0 | 152086 | gtex_brain_putamen_basal |
| rs3094614 | 6 | 30181275 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 152244 | gtex_brain_putamen_basal |
| rs3132669 | 6 | 30182826 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 153795 | gtex_brain_putamen_basal |
| rs200564848 | 6 | 30185239 | ZNRD1 | ENSG00000066379.10 | 6.732E-8 | 0 | 156208 | gtex_brain_putamen_basal |
| rs528290681 | 6 | 30185241 | ZNRD1 | ENSG00000066379.10 | 6.732E-8 | 0 | 156210 | gtex_brain_putamen_basal |
| rs374589844 | 6 | 30185523 | ZNRD1 | ENSG00000066379.10 | 1.612E-8 | 0 | 156492 | gtex_brain_putamen_basal |
| rs566358694 | 6 | 30186120 | ZNRD1 | ENSG00000066379.10 | 7.041E-7 | 0 | 157089 | gtex_brain_putamen_basal |
| rs2158284 | 6 | 30186632 | ZNRD1 | ENSG00000066379.10 | 9.49E-8 | 0 | 157601 | gtex_brain_putamen_basal |
| rs2158283 | 6 | 30186635 | ZNRD1 | ENSG00000066379.10 | 9.371E-8 | 0 | 157604 | gtex_brain_putamen_basal |
| rs2106071 | 6 | 30186819 | ZNRD1 | ENSG00000066379.10 | 5.986E-8 | 0 | 157788 | gtex_brain_putamen_basal |
| rs2106070 | 6 | 30186863 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 157832 | gtex_brain_putamen_basal |
| rs3132668 | 6 | 30187164 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 158133 | gtex_brain_putamen_basal |
| rs3094132 | 6 | 30187434 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 158403 | gtex_brain_putamen_basal |
| rs3130387 | 6 | 30187887 | ZNRD1 | ENSG00000066379.10 | 1.757E-7 | 0 | 158856 | gtex_brain_putamen_basal |
| rs3130388 | 6 | 30188158 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 159127 | gtex_brain_putamen_basal |
| rs3130389 | 6 | 30188199 | ZNRD1 | ENSG00000066379.10 | 4.998E-7 | 0 | 159168 | gtex_brain_putamen_basal |
| rs3094131 | 6 | 30190434 | ZNRD1 | ENSG00000066379.10 | 6.415E-8 | 0 | 161403 | gtex_brain_putamen_basal |
| rs3130391 | 6 | 30190640 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 161609 | gtex_brain_putamen_basal |
| rs3130392 | 6 | 30191455 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 162424 | gtex_brain_putamen_basal |
| rs3132667 | 6 | 30191587 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 162556 | gtex_brain_putamen_basal |
| rs9280925 | 6 | 30191677 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 162646 | gtex_brain_putamen_basal |
| rs3129689 | 6 | 30192803 | ZNRD1 | ENSG00000066379.10 | 6.542E-8 | 0 | 163772 | gtex_brain_putamen_basal |
| rs3132666 | 6 | 30193513 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 164482 | gtex_brain_putamen_basal |
| rs2040486 | 6 | 30194103 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 165072 | gtex_brain_putamen_basal |
| rs3130393 | 6 | 30194531 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 165500 | gtex_brain_putamen_basal |
| rs3132665 | 6 | 30195009 | ZNRD1 | ENSG00000066379.10 | 6.515E-8 | 0 | 165978 | gtex_brain_putamen_basal |
| rs3130394 | 6 | 30195059 | ZNRD1 | ENSG00000066379.10 | 4.752E-7 | 0 | 166028 | gtex_brain_putamen_basal |
| rs3094140 | 6 | 30196313 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 167282 | gtex_brain_putamen_basal |
| rs9280926 | 6 | 30196356 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 167325 | gtex_brain_putamen_basal |
| rs3130395 | 6 | 30196678 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 167647 | gtex_brain_putamen_basal |
| rs3129690 | 6 | 30196855 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 167824 | gtex_brain_putamen_basal |
| rs547837712 | 6 | 30196900 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 167869 | gtex_brain_putamen_basal |
| rs3129691 | 6 | 30197037 | ZNRD1 | ENSG00000066379.10 | 5.888E-8 | 0 | 168006 | gtex_brain_putamen_basal |
| rs3094133 | 6 | 30197288 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 168257 | gtex_brain_putamen_basal |
| rs3094139 | 6 | 30197995 | ZNRD1 | ENSG00000066379.10 | 4.998E-7 | 0 | 168964 | gtex_brain_putamen_basal |
| rs916572 | 6 | 30198689 | ZNRD1 | ENSG00000066379.10 | 5.565E-7 | 0 | 169658 | gtex_brain_putamen_basal |
| rs1573295 | 6 | 30199067 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 170036 | gtex_brain_putamen_basal |
| rs1013518 | 6 | 30199512 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 170481 | gtex_brain_putamen_basal |
| rs1015430 | 6 | 30200672 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 171641 | gtex_brain_putamen_basal |
| rs916571 | 6 | 30201955 | ZNRD1 | ENSG00000066379.10 | 4.998E-7 | 0 | 172924 | gtex_brain_putamen_basal |
| rs916568 | 6 | 30202052 | ZNRD1 | ENSG00000066379.10 | 6.507E-8 | 0 | 173021 | gtex_brain_putamen_basal |
| rs3132674 | 6 | 30202429 | ZNRD1 | ENSG00000066379.10 | 4.998E-7 | 0 | 173398 | gtex_brain_putamen_basal |
| rs3132673 | 6 | 30202442 | ZNRD1 | ENSG00000066379.10 | 4.998E-7 | 0 | 173411 | gtex_brain_putamen_basal |
| rs885915 | 6 | 30202715 | ZNRD1 | ENSG00000066379.10 | 9.837E-7 | 0 | 173684 | gtex_brain_putamen_basal |
| rs885914 | 6 | 30202767 | ZNRD1 | ENSG00000066379.10 | 9.501E-7 | 0 | 173736 | gtex_brain_putamen_basal |
| rs1264687 | 6 | 30203310 | ZNRD1 | ENSG00000066379.10 | 5.418E-8 | 0 | 174279 | gtex_brain_putamen_basal |
| rs5875248 | 6 | 30203312 | ZNRD1 | ENSG00000066379.10 | 6.351E-8 | 0 | 174281 | gtex_brain_putamen_basal |
| rs1986773 | 6 | 30203567 | ZNRD1 | ENSG00000066379.10 | 1.875E-6 | 0 | 174536 | gtex_brain_putamen_basal |
| rs954037 | 6 | 30203602 | ZNRD1 | ENSG00000066379.10 | 9.258E-8 | 0 | 174571 | gtex_brain_putamen_basal |
| rs954038 | 6 | 30203659 | ZNRD1 | ENSG00000066379.10 | 1.699E-7 | 0 | 174628 | gtex_brain_putamen_basal |
| rs2844780 | 6 | 30204526 | ZNRD1 | ENSG00000066379.10 | 9.837E-7 | 0 | 175495 | gtex_brain_putamen_basal |
| rs2517588 | 6 | 30204714 | ZNRD1 | ENSG00000066379.10 | 9.917E-7 | 0 | 175683 | gtex_brain_putamen_basal |
| rs548012279 | 6 | 30204868 | ZNRD1 | ENSG00000066379.10 | 1.717E-7 | 0 | 175837 | gtex_brain_putamen_basal |
| rs2844779 | 6 | 30205407 | ZNRD1 | ENSG00000066379.10 | 9.69E-7 | 0 | 176376 | gtex_brain_putamen_basal |
| rs2844778 | 6 | 30205991 | ZNRD1 | ENSG00000066379.10 | 1.15E-6 | 0 | 176960 | gtex_brain_putamen_basal |
| rs3094639 | 6 | 30206753 | ZNRD1 | ENSG00000066379.10 | 1.243E-6 | 0 | 177722 | gtex_brain_putamen_basal |
| rs35601018 | 6 | 30207784 | ZNRD1 | ENSG00000066379.10 | 2.525E-7 | 0 | 178753 | gtex_brain_putamen_basal |
| rs2253164 | 6 | 30209068 | ZNRD1 | ENSG00000066379.10 | 9.837E-7 | 0 | 180037 | gtex_brain_putamen_basal |
| rs9261599 | 6 | 30214146 | ZNRD1 | ENSG00000066379.10 | 1.242E-6 | 0 | 185115 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | IEA | - | |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0030528 | transcription regulator activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0045449 | regulation of transcription | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| KEGG PYRIMIDINE METABOLISM | 98 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG RNA POLYMERASE | 29 | 12 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |