SZGR2

Summary ?

GeneID	3481
Symbol	IGF2
Synonyms	C11orf43\|GRDF\|IGF-II\|PP9974
Description	insulin like growth factor 2
Reference	MIM:147470\|HGNC:HGNC:5466\|Ensembl:ENSG00000167244\|HPRD:00939\|HPRD:17410\|Vega:OTTHUMG00000009395
Gene type	protein-coding
Map location	11p15.5
Pascal p-value	0.881
Fetal beta	-0.11

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005179	hormone activity	IEA		-
GO:0005159	insulin-like growth factor receptor binding	TAS		1845984
GO:0005158	insulin receptor binding	IPI		12138094
GO:0005515	protein binding	IEA		-
GO:0008083	growth factor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001501	skeletal system development	TAS		8298652
GO:0006349	genetic imprinting	TAS		8968759
GO:0009887	organ morphogenesis	IEA		-
GO:0008283	cell proliferation	IEA		-
GO:0008286	insulin receptor signaling pathway	TAS		1845984
GO:0007275	multicellular organismal development	TAS		6382022
GO:0032583	regulation of gene-specific transcription	NAS		12881524
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
GPC3	DGSX \| OCI-5 \| SDYS \| SGB \| SGBS \| SGBS1	glypican 3	-	HPRD	8589713
IDE	FLJ35968 \| INSULYSIN	insulin-degrading enzyme	-	HPRD,BioGRID	1733942
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	9972281
IGFBP1	AFBP \| IBP1 \| IGF-BP25 \| PP12 \| hIGFBP-1	insulin-like growth factor binding protein 1	IGF-II interacts with IGFBP-1.	BIND	10407151
IGFBP1	AFBP \| IBP1 \| IGF-BP25 \| PP12 \| hIGFBP-1	insulin-like growth factor binding protein 1	-	HPRD,BioGRID	10810289
IGFBP2	IBP2 \| IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	IGF-II interacts with IGFBP-2.	BIND	10407151
IGFBP2	IBP2 \| IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	-	HPRD,BioGRID	1714916 \|2465304 \|8781553
IGFBP3	BP-53 \| IBP3	insulin-like growth factor binding protein 3	Reconstituted Complex	BioGRID	11600567 \|11749962
IGFBP3	BP-53 \| IBP3	insulin-like growth factor binding protein 3	IGF-II interacts with IGFBP-3.	BIND	10407151
IGFBP4	BP-4 \| HT29-IGFBP \| IBP4 \| IGFBP-4	insulin-like growth factor binding protein 4	IGF-II interacts with IGFBP-4.	BIND	10407151
IGFBP4	BP-4 \| HT29-IGFBP \| IBP4 \| IGFBP-4	insulin-like growth factor binding protein 4	-	HPRD,BioGRID	9722589
IGFBP5	IBP5	insulin-like growth factor binding protein 5	IGF-II interacts with IGFBP-5.	BIND	10407151
IGFBP5	IBP5	insulin-like growth factor binding protein 5	-	HPRD,BioGRID	9497324
IGFBP6	IBP6	insulin-like growth factor binding protein 6	IGF-II interacts with IGFBP-6.	BIND	10407151
IGFBP6	IBP6	insulin-like growth factor binding protein 6	-	HPRD,BioGRID	7683646
IGFBP7	FSTL2 \| IGFBP-7 \| IGFBP-7v \| IGFBPRP1 \| MAC25 \| PSF	insulin-like growth factor binding protein 7	-	HPRD,BioGRID	8939990
INSR	CD220 \| HHF5	insulin receptor	-	HPRD,BioGRID	9722981
NOV	CCN3 \| IGFBP9	nephroblastoma overexpressed gene	-	HPRD,BioGRID	10084601
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	transferrin	Reconstituted Complex	BioGRID	11749962
VTN	V75 \| VN \| VNT	vitronectin	-	HPRD,BioGRID	10342887

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	16	12	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN	29	21	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER	22	19	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 UP	30	24	All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC	35	25	All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS	31	24	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS IMPRINTED AND X LINKED	17	8	All SZGR 2.0 genes in this pathway
GOUYER TATI TARGETS DN	17	12	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
CHEN NEUROBLASTOMA COPY NUMBER GAINS	50	35	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP	61	40	All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN	52	34	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN	63	40	All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS DN	32	22	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
IYENGAR RESPONSE TO ADIPOCYTE FACTORS	10	8	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA	81	64	All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS	7	5	All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1B	23	14	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2	50	34	All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP	89	51	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5	126	78	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN	91	64	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP	82	51	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN	25	21	All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS	36	32	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3	36	24	All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE UP	31	21	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP	69	46	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS DN	24	14	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3	269	159	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON DN	52	30	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3	349	234	All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3	102	76	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3	341	243	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN	92	60	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN	106	77	All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES	63	47	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-141/200a	3466	3473	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	3466	3473	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-324-3p	2207	2213	m8	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-544	2297	2303	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: IGF2