Gene Page: IL2RB

Summary
GeneID  3560
Symbol  IL2RB
Synonyms  CD122|P70-75
Description  interleukin 2 receptor, beta
See related  HGNC:6009|MIM:146710|Ensembl:ENSG00000100385|HPRD:00896|
Locus tag  RP5-1170K4.6
Gene type  protein-coding
Map location  22q13|22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004896cytokine receptor activityIEA-
GO:0004911interleukin-2 receptor activityTAS2467293 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS2467293 
GO:0007165signal transductionTAS2785715 
GO:0019221cytokine-mediated signaling pathwayIDA7736574 
GO:0045885positive regulation of survival gene product expressionIDA7736574 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0009897external side of plasma membraneISS-
GO:0005886plasma membraneTAS2467293 
GO:0005887integral to plasma membraneTAS8514792 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CISHCIS | CIS-1 | G18 | SOCScytokine inducible SH2-containing protein-HPRD,BioGRID10514520 
EIF3BEIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1eukaryotic translation initiation factor 3, subunit Bin vivoBioGRID7693677 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1IL-2R-beta interacts with RACK-1.BIND12960323 
-HPRD,BioGRID12960323 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10602027 
IL15IL-15 | MGC9721interleukin 15-HPRD,BioGRID8026467 |9176231 
IL15RAMGC104179interleukin 15 receptor, alpha-HPRD,BioGRID7641685 
IL2IL-2 | TCGF | lymphokineinterleukin 2-HPRD,BioGRID8049354 |11035066 
IL2 interacts with IL2RB. This interaction was modeled on a demonstrated interaction between radiolabeled IL2 from an unspecified species and IL2RB from human.BIND2303462 
IL2RACD25 | IDDM10 | IL2R | TCGFRinterleukin 2 receptor, alpha-HPRD11886175 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD11886175 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID7973659 |12133952 
IL-2R-beta interacts with Jak1.BIND12133952 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID7973659 |9553136 
|10825200 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID2047859 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID9774657 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD,BioGRID12200137 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID8294403 |10602027 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID11133764 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID10602027 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10602027 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID10602027 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID10602027 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY 3427All SZGR genes in this pathway
PID_IL2_STAT5_PATHWAY 3023All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING 2721All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_DN 4226All SZGR genes in this pathway
LIU_CDX2_TARGETS_UP 3622All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
YE_METASTATIC_LIVER_CANCER 2713All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP 5129All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T4 9469All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P4 10062All SZGR genes in this pathway
GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_UP 1912All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD 2115All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
HAHTOLA_CTCL_PATHOGENESIS 169All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
CERIBELLI_PROMOTERS_INACTIVE_AND_BOUND_BY_NFY 4420All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_6 2920All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_UP 5139All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway


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