SZGR2

Summary ?

GeneID	3759
Symbol	KCNJ2
Synonyms	ATFB9\|HHBIRK1\|HHIRK1\|IRK1\|KIR2.1\|LQT7\|SQT3
Description	potassium voltage-gated channel subfamily J member 2
Reference	MIM:600681\|HGNC:HGNC:6263\|Ensembl:ENSG00000123700\|HPRD:02815\|Vega:OTTHUMG00000180351
Gene type	protein-coding
Map location	17q24.3
Pascal p-value	0.725
Sherlock p-value	0.083
DEG p-value	DEG:Zhao_2015:p=2.48e-04:q=0.0872
Fetal beta	-1.406

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Zhao_2015	RNA Sequencing analysis	Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0018

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
THAP4	0.57	0.54
ATF5	0.57	0.57
PFKL	0.56	0.60
FTSJ2	0.56	0.55
RCCD1	0.56	0.60
POFUT2	0.56	0.59
ABCD1	0.56	0.59
C19orf61	0.55	0.58
TRAF2	0.55	0.58
STARD3	0.55	0.56

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.47	-0.51
MT-CO2	-0.46	-0.51
AF347015.27	-0.44	-0.49
AF347015.21	-0.43	-0.48
MT-CYB	-0.43	-0.49
AF347015.33	-0.43	-0.47
AF347015.8	-0.42	-0.48
AF347015.2	-0.39	-0.46
AF347015.15	-0.39	-0.45
MYL3	-0.39	-0.43

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		11287423 \|12923176
GO:0005242	inward rectifier potassium channel activity	TAS		7696590
GO:0005244	voltage-gated ion channel activity	IEA		-
GO:0030955	potassium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006811	ion transport	IEA		-
GO:0006813	potassium ion transport	TAS		7696590
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0005887	integral to plasma membrane	TAS		7696590

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	25	17	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS	31	20	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR	37	22	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN	53	34	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K4ME3 AND H3K27ME3	34	21	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3	38	34	All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3	126	83	All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN	37	26	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3	137	85	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3	445	257	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	366	373	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	366	372	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	366	372	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-132/212	2675	2681	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	2675	2681	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-135	1468	1474	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1468	1474	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a	455	461	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	455	461	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	2160	2167	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-182	518	524	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-19	732	739	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	732	739	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-193	545	552	1A,m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	545	552	1A,m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-200bc/429	1447	1453	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-219	3572	3578	m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-26	3144	3151	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-320	2725	2731	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-410	3665	3671	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-431	357	363	m8	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-431	357	363	m8	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-455	203	210	1A,m8	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-495	2414	2420	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	2504	2510	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-503	2161	2167	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-503	2161	2167	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-505	457	464	1A,m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-7	3623	3629	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	713	720	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-9	713	720	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	518	524	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KCNJ2