Gene Page: SMAD5

Summary
GeneID  4090
Symbol  SMAD5
Synonyms  DKFZp781C1895|DKFZp781O1323|Dwfc|JV5-1|MADH5
Description  SMAD family member 5
See related  HGNC:6771|MIM:603110|Ensembl:ENSG00000113658|HPRD:04381|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityNAS8673135 
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0016563transcription activator activityNAS10708949 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007165signal transductionNAS9759503 
GO:0007179transforming growth factor beta receptor signaling pathwayNAS10708948 
GO:0009880embryonic pattern specificationISS-
GO:0030509BMP signaling pathwayEXP15621726 
GO:0030509BMP signaling pathwayISS-
GO:0030218erythrocyte differentiationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0060048cardiac muscle contractionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9436979 |17356069 
GO:0005622intracellularNAS9759503 
GO:0005634nucleusNAS9759503 
GO:0005654nucleoplasmEXP11121043 
GO:0005667transcription factor complexIEA-
GO:0005737cytoplasmIEA-
GO:0016021integral to membraneNAS10708949 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1ACTRI | ACVR1A | ACVRLK2 | ALK2 | FOP | SKR1 | TSRIactivin A receptor, type IAffinity Capture-WesternBioGRID9748228 |10652350 
-HPRD9748228 |10583507 
|10652350 
BMP6VGR | VGR1bone morphogenetic protein 6-HPRD10504300 
GDF6BMP13 | CDMP2 | KFS | KFSL | MGC158100 | MGC158101 | SGM1growth differentiation factor 6-HPRD15246821 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1Affinity Capture-WesternBioGRID10531362 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2Affinity Capture-WesternBioGRID10531362 
RUNX3AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aCrunt-related transcription factor 3Affinity Capture-WesternBioGRID10531362 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Affinity Capture-WesternBioGRID10531362 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD,BioGRID11163184 
ZEB2KIAA0569 | SIP-1 | SIP1 | SMADIP1 | ZFHX1Bzinc finger E-box binding homeobox 2-HPRD10400677 
ZNF8HF.18 | Zfp128zinc finger protein 8-HPRD12370310 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_CTCF_PATHWAY 2318All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
REACTOME_SIGNALING_BY_BMP 2315All SZGR genes in this pathway
TURASHVILI_BREAST_NORMAL_DUCTAL_VS_LOBULAR_UP 6840All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP 11966All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP 6238All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MATZUK_EMBRYONIC_GERM_CELL 1916All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
BAE_BRCA1_TARGETS_DN 3227All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50618951901m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/301846852m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-135518051871A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-15/16/195/424/497788794m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d848854m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-19845851m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-224632638m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-54417m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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