Gene Page: MDM4

Summary
GeneID  4194
Symbol  MDM4
Synonyms  DKFZp781B1423|HDMX|MDMX|MGC132766|MRP1
Description  Mdm4 p53 binding protein homolog (mouse)
See related  HGNC:6974|MIM:602704|Ensembl:ENSG00000198625|HPRD:04082|
Locus tag  RP11-430C7.1
Gene type  protein-coding
Map location  1q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0238 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI10469568 |10608892 
GO:0008270zinc ion bindingIEA-
GO:0008270zinc ion bindingTAS10608892 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA9226370 
GO:0006461protein complex assemblyIDA10608892 
GO:0008285negative regulation of cell proliferationTAS9226370 
GO:0006915apoptosisIEP14660608 
GO:0042177negative regulation of protein catabolic processIMP10608892 
GO:0050821protein stabilizationIEP10608892 
GO:0045023G0 to G1 transitionIEP12101245 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005634nucleusNAS9226370 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARF1-ADP-ribosylation factor 1-HPRD11297540 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to MCDC2 interacts with MDM4 (MDMX). This interaction was modeled on a demonstrated interaction between human CDC2, and MDM4 from an unspecified species.BIND15735705 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Affinity Capture-WesternBioGRID11297540 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1-HPRD,BioGRID12532331 
E2F-1 interacts with MDMX. This interaction was modeled on a demonstrated interaction between human E2F-1 and mouse MDMX.BIND12532331 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID12483531 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)MDM2 interacts with MDM4 (MDMX).BIND10608892 
-HPRD,BioGRID10218570 |12393902 
|12483531 
Mdm2 interacts with Hdmx.BIND15916963 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1pRb interacts with MDMX. This interaction was modeled on a demonstrated interaction between mouse MDMX and human pRb.BIND12532331 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID12483531 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Reconstituted ComplexBioGRID12483531 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Biochemical Activity
Reconstituted Complex		BioGRID9226370 |12393902 
-HPRD8895579 |9226370 
|11528400 |12393902 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Reconstituted ComplexBioGRID12393902 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)Hdmx interacts with HAUSP.BIND15916963 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_SIZE_UP 2312All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_UP 8557All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN 7550All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_UP 7536All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_UP 6642All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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