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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: MECP2

Summary

GeneID

4204

Symbol

MECP2

Synonyms

AUTSX3|DKFZp686A24160|MRX16|MRX79|MRXS13|MRXSL|PPMX|RTS|RTT

Description

methyl CpG binding protein 2 (Rett syndrome)

Locus tag

Gene type

protein-coding

Map location

Xq28

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

TAS

9620804

GO:0003714

transcription corepressor activity

TAS

10773092

GO:0005515

protein binding

IPI

15696166

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

TAS

9620804

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

10773092

GO:0005730

nucleolus

IDA

18029348

GO:0005739

mitochondrion

IDA

18029348

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
HMGB1	DKFZp686A04236 \| HMG1 \| HMG3 \| SBP-1	high-mobility group box 1	Reconstituted Complex	BioGRID	11748221
HMGB1	DKFZp686A04236 \| HMG1 \| HMG3 \| SBP-1	high-mobility group box 1	HMGB1 interacts with MECP2. This interaction was modelled on a demonstrated interaction between rat HMGB1 and human MECP2.	BIND	11748221
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	-	HPRD,BioGRID	11441023
PRPF40A	FBP-11 \| FBP11 \| FLAF1 \| FLJ20585 \| FNBP3 \| HIP10 \| HYPA \| NY-REN-6	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	-	HPRD,BioGRID	9171351
SKI	SKV	v-ski sarcoma viral oncogene homolog (avian)	-	HPRD,BioGRID	11441023
SMARCA2	BAF190 \| BRM \| FLJ36757 \| MGC74511 \| SNF2 \| SNF2L2 \| SNF2LA \| SWI2 \| Sth1p \| hBRM \| hSNF2a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	MeCP2 interacts with Brm.	BIND	15696166

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
LIU_SOX4_TARGETS_DN	309	191	All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN	70	38	All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN	121	84	All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP	158	103	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN	485	334	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN	637	377	All SZGR genes in this pathway
RICKMAN_METASTASIS_UP	344	180	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	86	57	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN	318	220	All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN	434	302	All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6	153	112	All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP	45	33	All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN	940	425	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	510	309	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
ONO_AML1_TARGETS_UP	24	14	All SZGR genes in this pathway
ONO_FOXP3_TARGETS_UP	23	15	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	3444	3450	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-103/107	276	282	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
				hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-122	385	391	m8	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-124.1	8541	8547	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	8541	8547	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	8541	8547	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-129-5p	6286	6292	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	6286	6292	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	976	983	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
				hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212	6887	6894	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	6887	6894	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-141/200a	5283	5289	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	5283	5289	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-148/152	8398	8404	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-155	6322	6328	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d	242	248	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	8465	8472	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	3681	3687	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-19	239	245	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-192/215	3388	3394	m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	3388	3394	m8	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-194	6889	6895	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-196	3443	3449	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
				hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
				hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
				hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-203.1	8447	8453	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-204/211	5606	5612	1A	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	5606	5612	1A	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-218	197	203	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-22	43	49	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-26	6765	6771	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	6765	6771	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	8454	8460	m8	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-3p	98	104	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-30-5p	2053	2060	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	3857	3863	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-326	7210	7216	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-328	224	230	m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-34/449	3911	3917	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-34b	4496	4502	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-361	5584	5591	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	8525	8531	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	5502	5508	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
				hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
				hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-378	2308	2314	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	2308	2314	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-410	5476	5482	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-410	5476	5482	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-455	1139	1145	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-499	2128	2134	m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-504	4507	4513	m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU
miR-505	7097	7103	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-7	929	935	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	2282	2288	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	3680	3687	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.