SZGR2

Summary ?

GeneID	4204
Symbol	MECP2
Synonyms	AUTSX3\|MRX16\|MRX79\|MRXS13\|MRXSL\|PPMX\|RS\|RTS\|RTT
Description	methyl-CpG binding protein 2
Reference	MIM:300005\|HGNC:HGNC:6990\|Ensembl:ENSG00000169057\|HPRD:02050\|Vega:OTTHUMG00000024229
Gene type	protein-coding
Map location	Xq28
Sherlock p-value	0.642
TADA p-value	0.012
Fetal beta	0.437
Support	Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:McCarthy_2014	Whole Exome Sequencing analysis	Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
MECP2	chrX	153296711	C	T	NM_001110792	p.R202C	missense SNV	C	D	Schizophrenia	DNM:McCarthy_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003677	DNA binding	TAS		9620804
GO:0003714	transcription corepressor activity	TAS		10773092
GO:0005515	protein binding	IPI		15696166
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS		9620804
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	TAS		10773092
GO:0005730	nucleolus	IDA		18029348
GO:0005739	mitochondrion	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN	70	38	All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN	121	84	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP	86	57	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS UP	24	14	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	3444	3450	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-103/107	276	282	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
				hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
				hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-122	385	391	m8	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-124.1	8541	8547	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	8541	8547	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	8541	8547	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-129-5p	6286	6292	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	6286	6292	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	976	983	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
				hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212	6887	6894	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	6887	6894	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-141/200a	5283	5289	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	5283	5289	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-148/152	8398	8404	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-155	6322	6328	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d	242	248	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	8465	8472	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	3681	3687	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-19	239	245	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-192/215	3388	3394	m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	3388	3394	m8	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-194	6889	6895	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-196	3443	3449	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
				hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
				hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
				hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-203.1	8447	8453	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-204/211	5606	5612	1A	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	5606	5612	1A	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-218	197	203	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-22	43	49	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-26	6765	6771	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	6765	6771	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	8454	8460	m8	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-3p	98	104	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-30-5p	2053	2060	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	3857	3863	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-326	7210	7216	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-328	224	230	m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-34/449	3911	3917	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-34b	4496	4502	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-361	5584	5591	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	8525	8531	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	5502	5508	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
				hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
				hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-378	2308	2314	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	2308	2314	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-410	5476	5482	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-410	5476	5482	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-455	1139	1145	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-499	2128	2134	m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-504	4507	4513	m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU
miR-505	7097	7103	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-7	929	935	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	2282	2288	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	3680	3687	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MECP2