Gene Page: NEUROD1

Summary
GeneID  4760
Symbol  NEUROD1
Synonyms  BETA2|BHF-1|NEUROD|bHLHa3
Description  neurogenic differentiation 1
See related  HGNC:7762|MIM:601724|Ensembl:ENSG00000162992|HPRD:03428|
Locus tag  -
Gene type  protein-coding
Map location  2q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0024 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TRIP60.790.78
SYDE10.760.75
TRIP100.760.76
INPPL10.760.76
FKBP100.750.75
MOV100.750.77
LAMB20.740.76
CTDSP10.740.76
SIX50.730.75
TEAD30.720.71
Top 10 negatively co-expressed genes
RALYL-0.55-0.59
PPP3CB-0.53-0.56
HMGCLL1-0.51-0.57
PRKACB-0.50-0.55
FBXW7-0.50-0.54
RGS7-0.50-0.49
RAP1GDS1-0.49-0.53
C20orf7-0.49-0.58
ELOVL4-0.49-0.53
C1orf52-0.49-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA10545951 
GO:0003702RNA polymerase II transcription factor activityIDA10545951 
GO:0008134transcription factor bindingIPI10545951 
GO:0016563transcription activator activityIEA-
GO:0046982protein heterodimerization activityIPI10545951 
GO:0043565sequence-specific DNA bindingIDA10545951 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0022008neurogenesisTASneurogenesis (GO term level: 6)8786144 
GO:0030902hindbrain developmentIEABrain (GO term level: 8)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007263nitric oxide mediated signal transductionIDA17941991 
GO:0009952anterior/posterior pattern formationIEA-
GO:0009749response to glucose stimulusIMP10545951 
GO:0007275multicellular organismal developmentIEA-
GO:0043066negative regulation of apoptosisISS9308961 
GO:0031018endocrine pancreas developmentISS9308961 
GO:0042593glucose homeostasisISS9308961 
GO:0043010camera-type eye developmentIEA-
GO:0045165cell fate commitmentIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0048562embryonic organ morphogenesisISS9308961 
GO:0050796regulation of insulin secretionIC10545951 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD10757985 
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD10757985 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD10757985 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Affinity Capture-Western
Phenotypic Suppression		BioGRID11788592 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID10545951 
HAP1HAP2 | HIP5 | HLP | hHLP1huntingtin-associated protein 1-HPRD,BioGRID12881483 
HTTHD | IT15huntingtinAffinity Capture-WesternBioGRID12881483 
MAFARIPE3b1 | hMafAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)-HPRD,BioGRID15665000 
MAP3K10MLK2 | MSTmitogen-activated protein kinase kinase kinase 10Affinity Capture-Western
Biochemical Activity
Two-hybrid		BioGRID12881483 
PDX1GSF | IDX-1 | IPF1 | IUF1 | MODY4 | PDX-1 | STF-1pancreatic and duodenal homeobox 1-HPRD,BioGRID10636926 
PITX1BFT | POTX | PTX1paired-like homeodomain 1-HPRD9343431 
RREB1FINB | HNT | LZ321 | RREB-1 | Zep-1ras responsive element binding protein 1-HPRD12482979 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 2519All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_UP 15290All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_6HR 4023All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_UP 2315All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
ZHOU_PANCREATIC_ENDOCRINE_PROGENITOR 1411All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_DN 2012All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_4_DN 1611All SZGR genes in this pathway
MADAN_DPPA4_TARGETS 4626All SZGR genes in this pathway
ROLEF_GLIS3_TARGETS 3729All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101122912361A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/10790961Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-124.1613619m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5066136191Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1283642m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/301898904m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1373183251A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1383944001Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-144123012361Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-145121512211Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1533343411A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d7017071Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181831891Ahsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-19897903m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-1905235301A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-21711711177m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-2410461052m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367129813041Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-299-5p5775831Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-5p59661A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3283583641Ahsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
miR-3311621681Ahsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-34b145151m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-363991051Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-380-5p3913971Ahsa-miR-380-5pUGGUUGACCAUAGAACAUGCGC
hsa-miR-563AGGUUGACAUACGUUUCCC
miR-383295301m8hsa-miR-383brainAGAUCAGAAGGUGAUUGUGGCU
miR-4483353411Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-494967973m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-496116311701A,m8hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
miR-5445845901Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU
miR-93.hd/291-3p/294/295/302/372/373/520619625m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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