SZGR2

Summary ?

GeneID	51631
Symbol	LUC7L2
Synonyms	CGI-59\|CGI-74\|LUC7B2
Description	LUC7-like 2 pre-mRNA splicing factor
Reference	MIM:613056\|HGNC:HGNC:21608\|Ensembl:ENSG00000146963\|HPRD:17456\|Vega:OTTHUMG00000185163
Gene type	protein-coding
Map location	7q34
Pascal p-value	0.031
Sherlock p-value	0.966
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0179

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs6467822	chr7	138773010	LUC7L2	51631		0.13		cis
rs1507047	chr16	50932778	LUC7L2	51631		0.09		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	PubMed ID
GO:0005515	protein binding	IPI	17353931
GO:0008270	zinc ion binding	IEA	-
GO:0046872	metal ion binding	IEA	-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALB	DKFZp779N1935 \| PRO0883 \| PRO0903 \| PRO1341	albumin	Two-hybrid	BioGRID	16169070
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	Two-hybrid	BioGRID	16169070
C14orf139	FLJ21276	chromosome 14 open reading frame 139	Two-hybrid	BioGRID	16169070
CCDC53	CGI-116	coiled-coil domain containing 53	Two-hybrid	BioGRID	16169070
CDK5RAP2	C48 \| Cep215 \| DKFZp686B1070 \| DKFZp686D1070 \| KIAA1633 \| MCPH3	CDK5 regulatory subunit associated protein 2	Two-hybrid	BioGRID	16169070
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	Two-hybrid	BioGRID	16169070
FAM173A	C16orf24 \| MGC2494	family with sequence similarity 173, member A	Two-hybrid	BioGRID	16169070
FXR1	-	fragile X mental retardation, autosomal homolog 1	Two-hybrid	BioGRID	16169070
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD	15383276
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
KLHL20	KHLHX \| KLEIP \| KLHLX \| RP3-383J4.3	kelch-like 20 (Drosophila)	Two-hybrid	BioGRID	16169070
LPL	HDLCQ11 \| LIPD	lipoprotein lipase	Two-hybrid	BioGRID	16169070
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
MAN2A2	MANA2X	mannosidase, alpha, class 2A, member 2	Two-hybrid	BioGRID	16169070
MAP1LC3B	LC3B \| MAP1A/1BLC3	microtubule-associated protein 1 light chain 3 beta	Two-hybrid	BioGRID	16169070
NAP1L5	DRLM	nucleosome assembly protein 1-like 5	Two-hybrid	BioGRID	16169070
NASP	DKFZp547F162 \| FLB7527 \| FLJ31599 \| FLJ35510 \| MGC19722 \| MGC20372 \| MGC2297 \| PRO1999	nuclear autoantigenic sperm protein (histone-binding)	Two-hybrid	BioGRID	16169070
NAT9	DKFZp564C103 \| EBSP	N-acetyltransferase 9 (GCN5-related, putative)	Two-hybrid	BioGRID	16169070
NDUFA4L2	FLJ26118 \| NUOMS	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	Two-hybrid	BioGRID	16169070
NKAP	FLJ22626	NFKB activating protein	Two-hybrid	BioGRID	16169070
NSF	SKD2	N-ethylmaleimide-sensitive factor	Two-hybrid	BioGRID	16169070
NUTF2	NTF2 \| PP15	nuclear transport factor 2	Two-hybrid	BioGRID	16169070
OFD1	71-7A \| CXorf5 \| MGC117039 \| MGC117040 \| SGBS2	oral-facial-digital syndrome 1	Two-hybrid	BioGRID	16169070
PEA15	HMAT1 \| HUMMAT1H \| MAT1 \| MAT1H \| PEA-15 \| PED	phosphoprotein enriched in astrocytes 15	Two-hybrid	BioGRID	16169070
PTCD3	DKFZp666K071 \| FLJ20758	Pentatricopeptide repeat domain 3	Two-hybrid	BioGRID	16169070
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Two-hybrid	BioGRID	16169070
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Affinity Capture-MS	BioGRID	17353931
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SSFA2	CS-1 \| CS1 \| DKFZp313O1039 \| DKFZp779G0129 \| FLJ45996 \| KIAA1927 \| KRAP \| SPAG13	sperm specific antigen 2	Two-hybrid	BioGRID	16169070
SVIL	DKFZp686A17191	supervillin	Two-hybrid	BioGRID	16169070
ULK2	KIAA0623 \| Unc51.2	unc-51-like kinase 2 (C. elegans)	Two-hybrid	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	Two-hybrid	BioGRID	16169070
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Affinity Capture-MS	BioGRID	17353931
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	15324660
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-MS	BioGRID	17353931
ZCCHC10	FLJ20094	zinc finger, CCHC domain containing 10	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
GUO HEX TARGETS UP	81	54	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN	54	30	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D	280	158	All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS DN	40	26	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	904	911	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	904	911	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-320	350	356	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-9	923	929	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	724	730	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: LUC7L2