Gene Page: INPP5K

Summary ?
GeneID51763
SymbolINPP5K
SynonymsPPS|SKIP
Descriptioninositol polyphosphate-5-phosphatase K
ReferenceMIM:607875|HGNC:HGNC:33882|Ensembl:ENSG00000132376|HPRD:08489|Vega:OTTHUMG00000150648
Gene typeprotein-coding
Map location17p13.3
Pascal p-value0.004

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16002321 |17353931 
GO:0004445inositol-polyphosphate 5-phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0016312inositol bisphosphate phosphatase activityIDA10753883 
GO:0042577lipid phosphatase activityNAS10753883 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030036actin cytoskeleton organizationNAS10753883 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionIDAneuron, axon, neurite, dendrite (GO term level: 5)10753883 
GO:0005829cytosolIDA10753883 
GO:0005783endoplasmic reticulumIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG INOSITOL PHOSPHATE METABOLISM 5442All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3123All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 4834All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238135All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP 8648All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216124All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION 4028All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 14996All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-34/4495965m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-455326332m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG