Gene Page: PSMB9

Summary
GeneID  5698
Symbol  PSMB9
Synonyms  LMP2|MGC70470|PSMB6i|RING12|beta1i
Description  proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
See related  HGNC:9546|MIM:177045|Ensembl:ENSG00000204261|HPRD:01514|
Locus tag  DADB-223G19.3
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PAQR60.860.89
MVP0.850.88
PLEKHB10.840.88
S100A10.840.90
CSRP10.840.89
HLA-F0.830.87
CYP27A10.830.87
HPN0.830.87
PLEKHF10.830.83
PLA2G160.820.89
Top 10 negatively co-expressed genes
NKIRAS2-0.74-0.78
GSTA4-0.73-0.80
DUSP12-0.72-0.79
PURG-0.72-0.77
BLMH-0.72-0.77
PARP6-0.72-0.77
ZNF821-0.72-0.76
MARK3-0.71-0.75
PJA1-0.71-0.75
DNAJC9-0.71-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004298threonine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006955immune responseIEA-
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP15029244 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005839proteasome core complexIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PSMA2HC3 | MU | PMSA2 | PSC2proteasome (prosome, macropain) subunit, alpha type, 2-HPRD10436176 
PSMB10LMP10 | MECL1 | MGC1665 | beta2iproteasome (prosome, macropain) subunit, beta type, 10-HPRD10329130 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PROTEASOME 4828All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES 4829All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 5131All SZGR genes in this pathway
REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 4827All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC 4933All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS 5834All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 5631All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 5130All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 6536All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 5331All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 7238All SZGR genes in this pathway
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 7340All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 6434All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 5132All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 5230All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX 1711All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_DN 3222All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_UP 7432All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
DER_IFN_BETA_RESPONSE_UP 10267All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
CROMER_METASTASIS_UP 7946All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_UP 1610All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
BROWNE_INTERFERON_RESPONSIVE_GENES 6844All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_UP 3824All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_DN 5944All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_UP 1411All SZGR genes in this pathway
WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP 5838All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
BAUS_TFF2_TARGETS_UP 3222All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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