Gene Page: RAB27A
Summary ?
GeneID | 5873 |
Symbol | RAB27A |
Synonyms | GS2|HsT18676|RAB27|RAM |
Description | RAB27A, member RAS oncogene family |
Reference | MIM:603868|HGNC:HGNC:9766|Ensembl:ENSG00000069974|HPRD:04845|Vega:OTTHUMG00000131959 |
Gene type | protein-coding |
Map location | 15q21.3 |
Pascal p-value | 0.005 |
DEG p-value | DEG:Sanders_2014:DS1_p=0.142:DS1_beta=0.042400:DS2_p=2.18e-02:DS2_beta=0.114:DS2_FDR=1.20e-01 |
Fetal beta | -0.054 |
DMG | 1 (# studies) |
eGene | Cerebellar Hemisphere Cerebellum Cortex Nucleus accumbens basal ganglia Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DEG:Sanders_2013 | Microarray | Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls. | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg06032813 | 15 | 55582570 | RAB27A | 4.26E-8 | -0.016 | 1.18E-5 | DMG:Jaffe_2016 |
cg15345126 | 15 | 55582248 | RAB27A | 6.61E-8 | -0.01 | 1.63E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
PNPLA6 | 0.90 | 0.88 |
DCTN1 | 0.90 | 0.89 |
ABCF3 | 0.90 | 0.88 |
OTUD5 | 0.89 | 0.89 |
CACNB1 | 0.88 | 0.87 |
ENO2 | 0.88 | 0.88 |
MAPK8IP3 | 0.88 | 0.86 |
C17orf28 | 0.88 | 0.85 |
APLP1 | 0.88 | 0.88 |
ADRBK1 | 0.88 | 0.87 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.21 | -0.68 | -0.52 |
AF347015.31 | -0.59 | -0.47 |
MT-CO2 | -0.59 | -0.46 |
GNG11 | -0.59 | -0.49 |
AF347015.8 | -0.58 | -0.45 |
C1orf54 | -0.58 | -0.51 |
AP002478.3 | -0.57 | -0.50 |
NOSTRIN | -0.56 | -0.44 |
AF347015.2 | -0.56 | -0.39 |
AF347015.18 | -0.56 | -0.42 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0003924 | GTPase activity | TAS | 9066979 | |
GO:0005515 | protein binding | IEA | - | |
GO:0005525 | GTP binding | IEA | - | |
GO:0031489 | myosin V binding | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007596 | blood coagulation | IEA | - | |
GO:0007264 | small GTPase mediated signal transduction | IEA | - | |
GO:0006605 | protein targeting | IEA | - | |
GO:0016192 | vesicle-mediated transport | IEA | - | |
GO:0015031 | protein transport | IEA | - | |
GO:0043473 | pigmentation | IEA | - | |
GO:0032402 | melanosome transport | IEA | - | |
GO:0032400 | melanosome localization | IEA | - | |
GO:0030318 | melanocyte differentiation | IEA | - | |
GO:0043320 | natural killer cell degranulation | IEA | - | |
GO:0043316 | cytotoxic T cell degranulation | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0030425 | dendrite | IDA | neuron, axon, dendrite (GO term level: 6) | 11266474 |
GO:0001750 | photoreceptor outer segment | IEA | - | |
GO:0005794 | Golgi apparatus | IEA | - | |
GO:0005737 | cytoplasm | IDA | 18029348 | |
GO:0016020 | membrane | IEA | - | |
GO:0042470 | melanosome | IDA | 11266474 | |
GO:0030141 | secretory granule | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
C14orf1 | ERG28 | NET51 | chromosome 14 open reading frame 1 | Two-hybrid | BioGRID | 16169070 |
C1orf103 | FLJ11269 | RIF1 | RP11-96K19.1 | chromosome 1 open reading frame 103 | Two-hybrid | BioGRID | 16169070 |
C7orf64 | DKFZP564O0523 | DKFZp686D1651 | HSPC304 | chromosome 7 open reading frame 64 | Two-hybrid | BioGRID | 16169070 |
COPS6 | CSN6 | MOV34-34KD | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) | Two-hybrid | BioGRID | 16169070 |
EEF1A1 | CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1 | eukaryotic translation elongation factor 1 alpha 1 | Two-hybrid | BioGRID | 16169070 |
EXPH5 | DKFZp781H0795 | KIAA0624 | MGC133291 | MGC134967 | SLAC2-B | exophilin 5 | Affinity Capture-Western | BioGRID | 11773082 |
GDF9 | - | growth differentiation factor 9 | Two-hybrid | BioGRID | 16169070 |
GZMB | CCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECT | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | - | HPRD | 11266473 |
KIAA1377 | - | KIAA1377 | Two-hybrid | BioGRID | 16169070 |
MLPH | MGC2771 | MGC59733 | SLAC2-A | melanophilin | - | HPRD | 11773082 |11856727 |11980908 |12062444 |15059972 |
MLPH | MGC2771 | MGC59733 | SLAC2-A | melanophilin | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 11773082 |11980908 |12062444 |15059972 |
MYO5A | GS1 | MYH12 | MYO5 | MYR12 | myosin VA (heavy chain 12, myoxin) | - | HPRD,BioGRID | 12006666 |
MYRIP | DKFZp586F1018 | FLJ44025 | MGC130034 | MGC130035 | SLAC2-C | SLAC2C | myosin VIIA and Rab interacting protein | - | HPRD,BioGRID | 12590134 |
RPH3A | KIAA0985 | rabphilin 3A homolog (mouse) | Affinity Capture-Western | BioGRID | 12578829 |
RPH3AL | NOC2 | rabphilin 3A-like (without C2 domains) | - | HPRD,BioGRID | 12578829 |
STX1A | HPC-1 | STX1 | p35-1 | syntaxin 1A (brain) | - | HPRD | 12101244 |
SYTL1 | FLJ14996 | JFC1 | SLP1 | synaptotagmin-like 1 | - | HPRD,BioGRID | 11980908 |
SYTL1 | FLJ14996 | JFC1 | SLP1 | synaptotagmin-like 1 | - | HPRD | 12590134 |
SYTL2 | CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2 | synaptotagmin-like 2 | - | HPRD | 11773082 |12590134 |
SYTL2 | CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2 | synaptotagmin-like 2 | - | HPRD,BioGRID | 11773082 |
SYTL3 | MGC105130 | MGC118883 | MGC118884 | MGC118885 | SLP3 | synaptotagmin-like 3 | - | HPRD,BioGRID | 11773082 |12590134 |
SYTL4 | DKFZp451P0116 | FLJ40960 | SLP4 | synaptotagmin-like 4 | - | HPRD | 11773082|11865063 |
SYTL4 | DKFZp451P0116 | FLJ40960 | SLP4 | synaptotagmin-like 4 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 11773082 |11865063 |12101244 |12176990 |12590134 |
SYTL5 | slp5 | synaptotagmin-like 5 | - | HPRD,BioGRID | 12051743 |
UNC13D | FHL3 | HLH3 | HPLH3 | Munc13-4 | unc-13 homolog D (C. elegans) | Reconstituted Complex | BioGRID | 14699162 |
ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
BIOCARTA RAB PATHWAY | 12 | 8 | All SZGR 2.0 genes in this pathway |
REACTOME DIABETES PATHWAYS | 133 | 91 | All SZGR 2.0 genes in this pathway |
REACTOME INSULIN SYNTHESIS AND PROCESSING | 21 | 15 | All SZGR 2.0 genes in this pathway |
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
SAMOLS TARGETS OF KHSV MIRNAS DN | 62 | 35 | All SZGR 2.0 genes in this pathway |
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
GRABARCZYK BCL11B TARGETS UP | 81 | 40 | All SZGR 2.0 genes in this pathway |
VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | All SZGR 2.0 genes in this pathway |
DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
BARRIER CANCER RELAPSE NORMAL SAMPLE UP | 32 | 21 | All SZGR 2.0 genes in this pathway |
HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
WANG PROSTATE CANCER ANDROGEN INDEPENDENT | 66 | 37 | All SZGR 2.0 genes in this pathway |
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP | 87 | 58 | All SZGR 2.0 genes in this pathway |
WIELAND UP BY HBV INFECTION | 101 | 66 | All SZGR 2.0 genes in this pathway |
TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | All SZGR 2.0 genes in this pathway |
HALMOS CEBPA TARGETS UP | 52 | 34 | All SZGR 2.0 genes in this pathway |
AFFAR YY1 TARGETS DN | 234 | 137 | All SZGR 2.0 genes in this pathway |
VERNELL RETINOBLASTOMA PATHWAY UP | 70 | 47 | All SZGR 2.0 genes in this pathway |
BASSO CD40 SIGNALING UP | 101 | 76 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 18HR UP | 178 | 111 | All SZGR 2.0 genes in this pathway |
SONG TARGETS OF IE86 CMV PROTEIN | 60 | 42 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 24HR UP | 148 | 96 | All SZGR 2.0 genes in this pathway |
WANG SMARCE1 TARGETS UP | 280 | 183 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
ZHANG GATA6 TARGETS DN | 64 | 46 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP | 125 | 68 | All SZGR 2.0 genes in this pathway |
PARK APL PATHOGENESIS DN | 50 | 35 | All SZGR 2.0 genes in this pathway |
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 | 196 | 124 | All SZGR 2.0 genes in this pathway |
BOYAULT LIVER CANCER SUBCLASS G6 DN | 19 | 13 | All SZGR 2.0 genes in this pathway |
BOYAULT LIVER CANCER SUBCLASS G56 DN | 17 | 9 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION DN | 20 | 12 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO GONADOTROPHINS UP | 91 | 59 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO FORSKOLIN UP | 90 | 58 | All SZGR 2.0 genes in this pathway |
KAMIKUBO MYELOID MN1 NETWORK | 19 | 14 | All SZGR 2.0 genes in this pathway |
VERHAAK GLIOBLASTOMA MESENCHYMAL | 216 | 130 | All SZGR 2.0 genes in this pathway |
CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
CHICAS RB1 TARGETS LOW SERUM | 100 | 51 | All SZGR 2.0 genes in this pathway |
OHGUCHI LIVER HNF4A TARGETS UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
CHYLA CBFA2T3 TARGETS UP | 387 | 225 | All SZGR 2.0 genes in this pathway |
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN | 229 | 135 | All SZGR 2.0 genes in this pathway |
SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-124.1 | 338 | 345 | 1A,m8 | hsa-miR-124a | UUAAGGCACGCGGUGAAUGCCA |
miR-124/506 | 338 | 344 | 1A | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
hsa-miR-124brain | UAAGGCACGCGGUGAAUGCC |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.