Summary ?
GeneID5873
SymbolRAB27A
SynonymsGS2|HsT18676|RAB27|RAM
DescriptionRAB27A, member RAS oncogene family
ReferenceMIM:603868|HGNC:HGNC:9766|Ensembl:ENSG00000069974|HPRD:04845|Vega:OTTHUMG00000131959
Gene typeprotein-coding
Map location15q21.3
Pascal p-value0.005
DEG p-valueDEG:Sanders_2014:DS1_p=0.142:DS1_beta=0.042400:DS2_p=2.18e-02:DS2_beta=0.114:DS2_FDR=1.20e-01
Fetal beta-0.054
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Cortex
Nucleus accumbens basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DEG:Sanders_2013MicroarrayWhole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg060328131555582570RAB27A4.26E-8-0.0161.18E-5DMG:Jaffe_2016
cg153451261555582248RAB27A6.61E-8-0.011.63E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PNPLA60.900.88
DCTN10.900.89
ABCF30.900.88
OTUD50.890.89
CACNB10.880.87
ENO20.880.88
MAPK8IP30.880.86
C17orf280.880.85
APLP10.880.88
ADRBK10.880.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.68-0.52
AF347015.31-0.59-0.47
MT-CO2-0.59-0.46
GNG11-0.59-0.49
AF347015.8-0.58-0.45
C1orf54-0.58-0.51
AP002478.3-0.57-0.50
NOSTRIN-0.56-0.44
AF347015.2-0.56-0.39
AF347015.18-0.56-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS9066979 
GO:0005515protein bindingIEA-
GO:0005525GTP bindingIEA-
GO:0031489myosin V bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007596blood coagulationIEA-
GO:0007264small GTPase mediated signal transductionIEA-
GO:0006605protein targetingIEA-
GO:0016192vesicle-mediated transportIEA-
GO:0015031protein transportIEA-
GO:0043473pigmentationIEA-
GO:0032402melanosome transportIEA-
GO:0032400melanosome localizationIEA-
GO:0030318melanocyte differentiationIEA-
GO:0043320natural killer cell degranulationIEA-
GO:0043316cytotoxic T cell degranulationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteIDAneuron, axon, dendrite (GO term level: 6)11266474 
GO:0001750photoreceptor outer segmentIEA-
GO:0005794Golgi apparatusIEA-
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0042470melanosomeIDA11266474 
GO:0030141secretory granuleIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
EXPH5DKFZp781H0795 | KIAA0624 | MGC133291 | MGC134967 | SLAC2-Bexophilin 5Affinity Capture-WesternBioGRID11773082 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
GZMBCCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECTgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)-HPRD11266473 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
MLPHMGC2771 | MGC59733 | SLAC2-Amelanophilin-HPRD11773082 |11856727 
|11980908 |12062444 
|15059972 
MLPHMGC2771 | MGC59733 | SLAC2-AmelanophilinAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11773082 |11980908 
|12062444 |15059972 
MYO5AGS1 | MYH12 | MYO5 | MYR12myosin VA (heavy chain 12, myoxin)-HPRD,BioGRID12006666 
MYRIPDKFZp586F1018 | FLJ44025 | MGC130034 | MGC130035 | SLAC2-C | SLAC2Cmyosin VIIA and Rab interacting protein-HPRD,BioGRID12590134 
RPH3AKIAA0985rabphilin 3A homolog (mouse)Affinity Capture-WesternBioGRID12578829 
RPH3ALNOC2rabphilin 3A-like (without C2 domains)-HPRD,BioGRID12578829 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD12101244 
SYTL1FLJ14996 | JFC1 | SLP1synaptotagmin-like 1-HPRD,BioGRID11980908 
SYTL1FLJ14996 | JFC1 | SLP1synaptotagmin-like 1-HPRD12590134 
SYTL2CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2synaptotagmin-like 2-HPRD11773082 |12590134 
SYTL2CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2synaptotagmin-like 2-HPRD,BioGRID11773082 
SYTL3MGC105130 | MGC118883 | MGC118884 | MGC118885 | SLP3synaptotagmin-like 3-HPRD,BioGRID11773082 |12590134 
SYTL4DKFZp451P0116 | FLJ40960 | SLP4synaptotagmin-like 4-HPRD11773082|11865063 
SYTL4DKFZp451P0116 | FLJ40960 | SLP4synaptotagmin-like 4Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11773082 |11865063 
|12101244 |12176990 
|12590134 
SYTL5slp5synaptotagmin-like 5-HPRD,BioGRID12051743 
UNC13DFHL3 | HLH3 | HPLH3 | Munc13-4unc-13 homolog D (C. elegans)Reconstituted ComplexBioGRID14699162 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA RAB PATHWAY 128All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING 2115All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN 6235All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 8140All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE NORMAL SAMPLE UP 3221All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 6637All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 10166All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 5234All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234137All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 7047All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 10176All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 6042All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280183All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN 6446All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 12568All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 5035All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196124All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 DN 1913All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 DN 179All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170105All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION DN 2012All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID MN1 NETWORK 1914All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS LOW SERUM 10051All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS UP 4430All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229135All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 13596All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.13383451A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5063383441Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC