Summary ?
GeneID60
SymbolACTB
SynonymsBRWS1|PS1TP5BP1
Descriptionactin, beta
ReferenceMIM:102630|HGNC:HGNC:132|Ensembl:ENSG00000075624|HPRD:00032|Vega:OTTHUMG00000023268
Gene typeprotein-coding
Map location7p22
Pascal p-value0.005
Sherlock p-value0.495
Fetal beta1.4
eGeneMyers' cis & trans
SupportSTRUCTURAL PLASTICITY
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0551 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10409262chr1958154954ACTB600.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17342765 
GO:0005524ATP bindingIEA-
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS6202424 
GO:0050998nitric-oxide synthase bindingIPI17502619 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007605sensory perception of soundIEA-
GO:0006928cell motionTAS6202424 |16130169 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005856cytoskeletonIEA-
GO:0005856cytoskeletonTAS16130169 
GO:0005625soluble fractionIEA-
GO:0005737cytoplasmTAS16130169 
GO:0035267NuA4 histone acetyltransferase complexIDA10966108 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABRASTARSactin-binding Rho activating protein-HPRD11983702 
ACTBPS1TP5BP1actin, betaAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9209005 |16189514 
ACTBPS1TP5BP1actin, betaActin interacts with itself to form an F-actin.BIND15361876 
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD8913639 
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1Two-hybridBioGRID16189514 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD11533442 |11721045 
C20orf20Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4chromosome 20 open reading frame 20-HPRD12963728 
CCT299D8.1 | CCT-beta | CCTB | MGC142074 | MGC142076 | PRO1633 | TCP-1-betachaperonin containing TCP1, subunit 2 (beta)-HPRD,BioGRID10748209|11580269 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)-HPRD,BioGRID11580269 
CCT8C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71chaperonin containing TCP1, subunit 8 (theta)-HPRD10748209 
CFL1CFLcofilin 1 (non-muscle)Two-hybridBioGRID16189514 
CFL2NEM7cofilin 2 (muscle)Affinity Capture-Western
Two-hybrid
BioGRID16189514 
CIITAC2TA | CIITAIV | MHC2TA | NLRAclass II, major histocompatibility complex, transactivatorBeta-actin interacts with p-MHC2TA.BIND15502823 
CLIC4CLIC4L | DKFZp566G223 | FLJ38640 | H1 | MTCLIC | huH1 | p64H1chloride intracellular channel 4-HPRD11563969 
CPNE1COPN1 | CPN1 | MGC1142copine I-HPRD12522145 
CPNE2COPN2 | CPN2 | DKFZp686E06199 | MGC16924copine II-HPRD12522145 
CPNE4COPN4 | CPN4 | MGC15604copine IV-HPRD12522145 
DNASE1DKFZp686H0155 | DNL1 | DRNI | FLJ38093 | FLJ44902deoxyribonuclease IDNASE1 (DNase I) interacts with ACTB (beta-actin).BIND15711563 
DSTNACTDP | ADF | bA462D18.2destrin (actin depolymerizing factor)Two-hybridBioGRID16189514 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
EMDEDMD | LEMD5 | STAemerin-HPRD12670476 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD7876308 
FLIIFLI | FLIL | Fli1 | MGC39265flightless I homolog (Drosophila)-HPRD9525888 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD10945978 
HNRNPUHNRPU | SAF-A | U21.1heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)ACTB (beta-actin) interacts with HNRPU (hnRNP U).BIND15711563 
IFI66-16 | FAM14C | G1P3 | IFI-6-16 | IFI616interferon, alpha-inducible protein 6Beta-actin interacts with p-G1P3.BIND15502823 
LGALS13GAL13 | PLAC8 | PP13lectin, galactoside-binding, soluble, 13-HPRD15009185 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Co-purificationBioGRID11839798 
NCALDMGC33870 | MGC74858neurocalcin deltaAffinity Capture-WesternBioGRID16189514 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Far WesternBioGRID11027608 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD11027608 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2Far WesternBioGRID11027608 
NEBLFLJ53769 | LNEBL | MGC119746 | MGC119747 | bA56H7.1nebulette-HPRD10470015 
NRAP-nebulin-related anchoring protein-HPRD9295142 
OSTF1FLJ20559 | OSF | SH3P2 | bA235O14.1osteoclast stimulating factor 1SH3P2 interacts with beta-actin.BIND15135048 
P2RX7MGC20089 | P2X7purinergic receptor P2X, ligand-gated ion channel, 7-HPRD11707406 
PCYT1BCCT-beta | CTBphosphate cytidylyltransferase 1, choline, betaCo-crystal StructureBioGRID11580269 
PFDN1PDF | PFD1prefoldin subunit 1-HPRD11535601 
PFN1-profilin 1-HPRD,BioGRID10411937 
PFN2D3S1319E | PFLprofilin 2-HPRD10600384 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD11373276 
PLD2-phospholipase D2-HPRD11373276 
POLR1BFLJ10816 | FLJ21921 | MGC131780 | RPA135 | RPA2 | Rpo1-2polymerase (RNA) I polypeptide B, 128kDaPol I interacts with actin.BIND15558034 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophin-HPRD9739080 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID11027608 
RAC2EN-7 | Gx | HSPC022ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)-HPRD,BioGRID11027608 
RIBIN-rRNA promoter binding proteinActin interacts with rDNA.BIND15558034 
RRN3DKFZp566E104 | MGC104238 | TIFIARRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)TIF-IA interacts with actin.BIND15558034 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID9845365 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Affinity Capture-WesternBioGRID9845365 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Affinity Capture-WesternBioGRID9845365 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD9209005 
SPTBN2GTRAP41 | SCA5spectrin, beta, non-erythrocytic 2Reconstituted ComplexBioGRID11357136 
SSH1FLJ38102 | KIAA1298 | SSH-1slingshot homolog 1 (Drosophila)Reconstituted ComplexBioGRID11832213 
SSH2KIAA1725 | MGC78588 | SSH-2slingshot homolog 2 (Drosophila)Reconstituted ComplexBioGRID11832213 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding protein-HPRD11673475 |11696420 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TPM2AMCD1 | DA1 | DA2B | TMSBtropomyosin 2 (beta)-HPRD9108196 
TPM3FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30tropomyosin 3-HPRD9108196 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6-HPRD14592989 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION 5632All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 8565All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 7659All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 9268All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 2815All SZGR 2.0 genes in this pathway
REACTOME PROTEIN FOLDING 5330All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE DN 2113All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP 5534All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214155All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN 5632All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
CAVARD LIVER CANCER MALIGNANT VS BENIGN 3219All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 4831All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 6648All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS DN 96All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 10866All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
RAHMAN TP53 TARGETS PHOSPHORYLATED 2118All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
PETRETTO CARDIAC HYPERTROPHY 3426All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7P22 AMPLICON 3827All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G1 G2 DN 2518All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE 4828All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL 2822All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 4029All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN 2616All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151100All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 7958All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 6536All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 3624All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 14199All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 3627All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR 3722All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN 5739All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148102All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL 3525All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS DN 1612All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP 4333All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE DN 139All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 9564All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 4731All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 7750All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 6647All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 8066All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP 11271All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 10264All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 11170All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 8650All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181101All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 14094All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
DORMOY ELAVL1 TARGETS 1710All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP 8752All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 9867All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 7252All SZGR 2.0 genes in this pathway
STEINER ERYTHROCYTE MEMBRANE GENES 1510All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.14124181Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-1451451521A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-205500506m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-4862722781Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-54453591Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU