Gene Page: NOD2

Summary
GeneID  64127
Symbol  NOD2
Synonyms  ACUG|BLAU|CARD15|CD|CLR16.3|IBD1|NLRC2|NOD2B|PSORAS1
Description  nucleotide-binding oligomerization domain containing 2
See related  HGNC:5331|MIM:605956|Ensembl:ENSG00000167207|HPRD:05810|
Locus tag  -
Gene type  protein-coding
Map location  16q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
ExpressionExpressionP value: 1.735 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0032500muramyl dipeptide bindingIDA15998797 
GO:0019901protein kinase bindingIPI15075345 
GO:0019899enzyme bindingIPI15753091 
GO:0050700CARD domain bindingIPI11087742 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002367cytokine production during immune responseIMP16260731 
GO:0002224toll-like receptor signaling pathwayIEA-
GO:0016045detection of bacteriumIDA15653568 
GO:0007242intracellular signaling cascadeIDA15653568 
GO:0042981regulation of apoptosisIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA11385577 
GO:0042742defense response to bacteriumIDA15653568 
GO:0032740positive regulation of interleukin-17 productionIMP17919942 
GO:0051259protein oligomerizationTAS15967716 
GO:0032498detection of muramyl dipeptideIDA15998797 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIDA11087742 
GO:0050718positive regulation of interleukin-1 beta secretionIDA15107016 
GO:0045087innate immune responseNAS17690884 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA15998797 
GO:0005622intracellularIEA-
GO:0005737cytoplasmTAS15967716 
GO:0009986cell surfaceIDA16714539 
GO:0005886plasma membraneIDA15998797 
GO:0008180signalosomeIDA17337451 
GO:0031982vesicleIDA15998797 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Affinity Capture-WesternBioGRID15107016 
CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.BIND15107016 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4CARD12 (CLAN) interacts with CARD15 (Nod2).BIND15107016 
-HPRD,BioGRID11472070 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID11087742 
Nod2 interaction with RICK enhances NF-kappaB activityBIND11087742 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 2317All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 169All SZGR genes in this pathway
REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION 1812All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_NOD1_2_SIGNALING_PATHWAY 3022All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
VALK_AML_CLUSTER_5 3324All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3784374431Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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