Gene Page: SOD1

Summary ?
GeneID6647
SymbolSOD1
SynonymsALS|ALS1|HEL-S-44|IPOA|SOD|hSod1|homodimer
Descriptionsuperoxide dismutase 1, soluble
ReferenceMIM:147450|HGNC:HGNC:11179|Ensembl:ENSG00000142168|HPRD:00937|Vega:OTTHUMG00000084878
Gene typeprotein-coding
Map location21q22.11
Pascal p-value0.31
Sherlock p-value0.043
Fetal beta-0.452
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7132043chr1280968399SOD166470.2trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GAK0.890.88
ARFGAP10.880.86
DNAJC110.860.83
CUL90.860.85
PLA2G60.860.83
ATG2A0.860.85
ZNF8390.860.82
C16orf580.850.81
DDX510.850.85
RAB11FIP30.850.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.78-0.67
MT-CO2-0.70-0.60
AF347015.31-0.70-0.61
AF347015.8-0.67-0.58
C1orf54-0.67-0.62
MT-CYB-0.65-0.55
CLEC2B-0.65-0.60
AF347015.27-0.64-0.57
AF347015.33-0.64-0.53
NOSTRIN-0.63-0.50

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005507copper ion bindingIDA17008312 
GO:0004784superoxide dismutase activityIDA15544046 |17324120 
GO:0008270zinc ion bindingIDA17381088 
GO:0016209antioxidant activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0051087chaperone bindingIPI9726962 
GO:0042803protein homodimerization activityNAS9726962 |10837872 
GO:0030346protein phosphatase 2B bindingIDA17324120 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048678response to axon injuryISSaxon (GO term level: 5)-
GO:0019226transmission of nerve impulseISSneuron (GO term level: 5)-
GO:0043524negative regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0000187activation of MAPK activityISS-
GO:0000303response to superoxideIDA16790527 
GO:0001541ovarian follicle developmentISS-
GO:0002262myeloid cell homeostasisISS-
GO:0001895retina homeostasisISS-
GO:0001890placenta developmentNAS12485882 
GO:0001819positive regulation of cytokine productionIDA15544046 
GO:0006302double-strand break repairISS-
GO:0006309DNA fragmentation during apoptosisISS-
GO:0008217regulation of blood pressureISS-
GO:0007283spermatogenesisISS-
GO:0009408response to heatISS-
GO:0007626locomotory behaviorISS-
GO:0007605sensory perception of soundISS-
GO:0007569cell agingIEP15377661 
GO:0007569cell agingIMP12871978 
GO:0007566embryo implantationISS-
GO:0007566embryo implantationNAS10920331 
GO:0006749glutathione metabolic processISS-
GO:0006879cellular iron ion homeostasisISS-
GO:0043065positive regulation of apoptosisIC16790527 
GO:0033081regulation of T cell differentiation in the thymusNAS16716898 
GO:0042493response to drugISS-
GO:0042554superoxide releaseIEA-
GO:0032287myelin maintenance in the peripheral nervous systemISS-
GO:0043085positive regulation of catalytic activityIDA17324120 
GO:0019430removal of superoxide radicalsISS-
GO:0042542response to hydrogen peroxideISS-
GO:0040014regulation of multicellular organism growthISS-
GO:0045541negative regulation of cholesterol biosynthetic processIDA15473258 
GO:0045859regulation of protein kinase activityIDA16254550 
GO:0050665hydrogen peroxide biosynthetic processIDA15544046 
GO:0050665hydrogen peroxide biosynthetic processISS-
GO:0046620regulation of organ growthNAS16716898 
GO:0046716muscle maintenanceISS-
GO:0048538thymus developmentNAS16716898 
GO:0060088auditory receptor cell stereocilium organizationISS-
GO:0060087relaxation of vascular smooth muscleISS-
GO:0045471response to ethanolISS-
GO:0055114oxidation reductionIEA-
GO:0060047heart contractionIDA9539776 
GO:0060052neurofilament cytoskeleton organizationISS-
GO:0051881regulation of mitochondrial membrane potentialIMP16790527 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIDAaxon, dendrite (GO term level: 4)17324120 
GO:0032839dendrite cytoplasmIDAdendrite (GO term level: 9)17324120 
GO:0005829cytosolIDA16790527 
GO:0005615extracellular spaceIDA7172448 |9453566 
GO:0005634nucleusIDA9726962 |17504823 
GO:0005737cytoplasmIDA9726962 |11527942 |17077646 
|17504823 
GO:0005739mitochondrionIDA16790527 
GO:0005759mitochondrial matrixNAS17008312 
GO:0005777peroxisomeNAS15766328 
GO:0005886plasma membraneIDA17077646 |17324120 
GO:0031012extracellular matrixIDA9699963 
GO:0031410cytoplasmic vesicleIDA17077646 
GO:0043234protein complexIDA17324120 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 3528All SZGR 2.0 genes in this pathway
BIOCARTA FREE PATHWAY 107All SZGR 2.0 genes in this pathway
BIOCARTA LONGEVITY PATHWAY 1513All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY 6537All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY 4429All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 3827All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS DN 3725All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 7760All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
HOUSTIS ROS 3629All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 6844All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN 4826All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 8655All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 7149All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 5233All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 5141All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE DN 139All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
VISALA RESPONSE TO HEAT SHOCK AND AGING DN 1412All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 4731All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 3322All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY UV IN WS 129All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 5641All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN 4531All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
MATZUK PREOVULATORY FOLLICLE 108All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 9163All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 8460All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-377107113m8hsa-miR-377AUCACACAAAGGCAACUUUUGU