SZGR2

Summary ?

GeneID	6709
Symbol	SPTAN1
Synonyms	EIEE5\|NEAS\|SPTA2
Description	spectrin alpha, non-erythrocytic 1
Reference	MIM:182810\|HGNC:HGNC:11273\|Ensembl:ENSG00000197694\|HPRD:01684\|Vega:OTTHUMG00000020754
Gene type	protein-coding
Map location	9q34.11
Pascal p-value	0.129
Sherlock p-value	0.868
Fetal beta	0.358
eGene	Meta
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet Darnell FMRP targets Ascano FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.7272

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HNRNPUL1	0.97	0.94
RAF1	0.97	0.96
MTA2	0.97	0.94
DDX23	0.97	0.97
UBE2I	0.97	0.95
SMARCB1	0.97	0.94
SF3B3	0.96	0.96
TRA2B	0.96	0.95
WDR33	0.96	0.96
FUBP1	0.96	0.96

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.78	-0.92
AF347015.27	-0.78	-0.92
C5orf53	-0.77	-0.78
MT-CO2	-0.77	-0.92
HLA-F	-0.77	-0.79
AIFM3	-0.76	-0.80
AF347015.33	-0.76	-0.90
S100B	-0.75	-0.84
FXYD1	-0.75	-0.89
MT-CYB	-0.75	-0.90

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	TAS		2307671
GO:0005509	calcium ion binding	IEA		-
GO:0005516	calmodulin binding	IEA		-
GO:0005200	structural constituent of cytoskeleton	TAS		2307671
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0051016	barbed-end actin filament capping	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9624143
GO:0005856	cytoskeleton	IEA		-
GO:0005624	membrane fraction	TAS		2307671
GO:0005737	cytoplasm	IEA		-
GO:0008091	spectrin	TAS		2307671

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Reconstituted Complex Two-hybrid	BioGRID	9593709
ACP1	HAAP \| MGC111030 \| MGC3499	acid phosphatase 1, soluble	-	HPRD	11971983
ACTB	PS1TP5BP1	actin, beta	-	HPRD	9209005
ADD1	ADDA \| MGC3339 \| MGC44427	adducin 1 (alpha)	-	HPRD,BioGRID	8663089
ADD2	ADDB	adducin 2 (beta)	-	HPRD	7642559
ANK1	ANK \| SPH1 \| SPH2	ankyrin 1, erythrocytic	-	HPRD	492324 \|2141335 \|2970468 \|2971657
CAPN3	CANP3 \| CANPL3 \| LGMD2 \| LGMD2A \| MGC10767 \| MGC11121 \| MGC14344 \| MGC4403 \| nCL-1 \| p94	calpain 3, (p94)	-	HPRD	9642272
CTNNA1	CAP102 \| FLJ36832	catenin (cadherin-associated protein), alpha 1, 102kDa	-	HPRD	11069925
DDX24	-	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	Two-hybrid	BioGRID	16169070
DES	CMD1I \| CSM1 \| CSM2 \| FLJ12025 \| FLJ39719 \| FLJ41013 \| FLJ41793	desmin	-	HPRD,BioGRID	2939097
DISC1	C1orf136 \| FLJ13381 \| FLJ21640 \| FLJ25311 \| FLJ41105 \| KIAA0457 \| SCZD9	disrupted in schizophrenia 1	An unspecified isoform of DISC1 interacts with SPTAN1.	BIND	14623284
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	Reconstituted Complex	BioGRID	12044158
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	-	HPRD	12049649
EPB42	MGC116735 \| MGC116737 \| PA	erythrocyte membrane protein band 4.2	-	HPRD,BioGRID	12049649
ERCC4	RAD1 \| XPF	excision repair cross-complementing rodent repair deficiency, complementation group 4	Affinity Capture-Western	BioGRID	12571280
EVL	RNB6	Enah/Vasp-like	AlphaII-spectrin interacts with EVL.	BIND	15656790
FANCA	FA \| FA-H \| FA1 \| FAA \| FACA \| FAH \| FANCH \| MGC75158	Fanconi anemia, complementation group A	Affinity Capture-Western Co-purification	BioGRID	10551855 \|11401546 \|12571280
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Affinity Capture-Western Co-purification	BioGRID	10551855 \|11401546
FANCG	FAG \| XRCC9	Fanconi anemia, complementation group G	Co-purification	BioGRID	11401546
GAP43	B-50 \| PP46	growth associated protein 43	-	HPRD	10521589
GRIA2	GLUR2 \| GLURB \| GluR-K2 \| HBGR2	glutamate receptor, ionotropic, AMPA 2	Affinity Capture-Western Far Western	BioGRID	10576550
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	9670010 \|10862698
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
NEFL	CMT1F \| CMT2E \| FLJ53642 \| NF-L \| NF68 \| NFL	neurofilament, light polypeptide	-	HPRD,BioGRID	1902666 \|3121319
PDE4D	DPDE3 \| HSPDE4D \| PDE4DN2 \| STRK1	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	PDE4D4 interacts with Fodrin. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Fodrin from an unspecified species.	BIND	10571082
PIN4	EPVH \| MGC138486 \| PAR14 \| PAR17	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	Two-hybrid	BioGRID	16169070
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	-	HPRD,BioGRID	3027087
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD	8163551
PTOV1	ACID2 \| DKFZp586I111 \| MGC71475	prostate tumor overexpressed 1	Two-hybrid	BioGRID	16169070
PTP4A1	DKFZp779M0721 \| HH72 \| PRL-1 \| PRL1 \| PTP(CAAX1) \| PTPCAAX1	protein tyrosine phosphatase type IVA, member 1	-	HPRD	11971983
SHANK1	SPANK-1 \| SSTRIP \| synamon	SH3 and multiple ankyrin repeat domains 1	-	HPRD,BioGRID	11509555
SHANK3	KIAA1650 \| PROSAP2 \| PSAP2 \| SPANK-2	SH3 and multiple ankyrin repeat domains 3	Two-hybrid	BioGRID	11509555
SLC9A2	NHE2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	-	HPRD	10579058
SPTB	HSpTB1	spectrin, beta, erythrocytic	-	HPRD,BioGRID	9890967
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	1905928
TANC1	KIAA1728 \| ROLSB \| TANC	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	-	HPRD	15673434
TES	DKFZp586B2022 \| MGC1146 \| TESS \| TESS-2	testis derived transcript (3 LIM domains)	AlphaII-spectrin interacts with Tes.	BIND	15656790
TSSC4	-	tumor suppressing subtransferable candidate 4	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY	29	21	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	13	11	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	23	19	All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS	20	15	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN	41	29	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP	204	140	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP	157	104	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP	177	113	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP	150	93	All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE NORMAL SAMPLE DN	31	19	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP	134	93	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP	62	35	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP	114	84	All SZGR 2.0 genes in this pathway
ULE SPLICING VIA NOVA2	43	38	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8	86	57	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE	206	117	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP	69	46	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP	84	52	All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG UP	41	26	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	48	54	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	48	54	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-29	132	138	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SPTAN1