SZGR2

Summary ?

GeneID	6714
Symbol	SRC
Synonyms	ASV\|SRC1\|c-SRC\|p60-Src
Description	SRC proto-oncogene, non-receptor tyrosine kinase
Reference	MIM:190090\|HGNC:HGNC:11283\|Ensembl:ENSG00000197122\|HPRD:01819\|Vega:OTTHUMG00000032417
Gene type	protein-coding
Map location	20q12-q13
Pascal p-value	0.228
Sherlock p-value	0.968
Fetal beta	0.082
Support	METABOTROPIC GLUTAMATE RECEPTOR G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 14.4947

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RASAL1	0.79	0.78
RASGEF1A	0.77	0.82
SLC7A4	0.76	0.83
SYN1	0.75	0.81
PRKCG	0.75	0.82
SYN2	0.75	0.81
SLC30A3	0.75	0.77
CHRM1	0.75	0.77
TMEM130	0.75	0.81
PNMAL2	0.74	0.77

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RBMX2	-0.39	-0.45
KIAA1949	-0.38	-0.26
CSRP2	-0.37	-0.43
SLA	-0.37	-0.02
TUBB2B	-0.37	-0.36
SH2D2A	-0.37	-0.41
FABP7	-0.36	-0.39
ZNF435	-0.36	-0.24
DACT1	-0.36	0.00
MYCN	-0.36	-0.03

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005070	SH3/SH2 adaptor activity	TAS		9020193
GO:0005515	protein binding	IPI		8681387 \|9763511
GO:0005524	ATP binding	IEA		-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0042169	SH2 domain binding	IPI		8070403
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007172	signal complex assembly	TAS		9924018
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0007243	protein kinase cascade	TAS		9020193
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10858437 \|11124251
GO:0005901	caveola	IDA		17848177
GO:0005886	plasma membrane	EXP		8845374 \|9028946 \|11124251 \|12506110 \|12907686 \|15574420

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	c-Abl interacts with Src. This interaction was modeled on a demonstrated interaction between human c-Abl and v-Src from the Rous Sarcoma virus.	BIND	1383690
ADAM12	MCMP \| MCMPMltna \| MLTN \| MLTNA	ADAM metallopeptidase domain 12	-	HPRD	11127814
ADAM15	MDC15	ADAM metallopeptidase domain 15	-	HPRD	11741929
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	Affinity Capture-Western	BioGRID	11013230
ADRB3	BETA3AR	adrenergic, beta-3-, receptor	-	HPRD,BioGRID	11013230
ADRBK1	BARK1 \| BETA-ARK1 \| FLJ16718 \| GRK2	adrenergic, beta, receptor kinase 1	-	HPRD,BioGRID	12624098
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	-	HPRD,BioGRID	9655255
AHR	-	aryl hydrocarbon receptor	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12024042
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	-	HPRD	15184363
ANXA2	ANX2 \| ANX2L4 \| CAL1H \| LIP2 \| LPC2 \| LPC2D \| P36 \| PAP-IV	annexin A2	-	HPRD,BioGRID	11106497
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Two-hybrid	BioGRID	11032808 \|15027889 \|15466214
ARHGAP1	CDC42GAP \| RHOGAP \| RHOGAP1 \| p50rhoGAP	Rho GTPase activating protein 1	-	HPRD,BioGRID	8253717
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Reconstituted Complex	BioGRID	11431473
ARNT	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12024042
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	-	HPRD,BioGRID	11877451
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	-	HPRD,BioGRID	9819391
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Affinity Capture-Western	BioGRID	10022920
AXL	JTK11 \| UFO	AXL receptor tyrosine kinase	-	HPRD,BioGRID	9178760
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	c-Src interacts with CAS.	BIND	9148935
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10085298 \|10487518 \|10739664 \|11514617 \|12397603 \|12615911
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	BCR interacts with Src. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and Src from Rous Sarcoma virus.	BIND	1383690
BMX	ETK \| PSCTK2 \| PSCTK3	BMX non-receptor tyrosine kinase	-	HPRD,BioGRID	10688651
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	-	HPRD,BioGRID	8910575
CAV2	CAV \| MGC12294	caveolin 2	Reconstituted Complex	BioGRID	12091389
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD	8635998
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Cbl interacts with Src. This interaction was modeled on a demonstrated interaction between human Cbl and Src from unspecified species.	BIND	15135048
CD2AP	CMS \| DKFZp586H0519	CD2-associated protein	-	HPRD	10339567
CD36	CHDS7 \| FAT \| GP3B \| GP4 \| GPIV \| PASIV \| SCARB3	CD36 molecule (thrombospondin receptor)	-	HPRD	7521304
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	Affinity Capture-Western Reconstituted Complex	BioGRID	11084024
CD46	MCP \| MGC26544 \| MIC10 \| TLX \| TRA2.10	CD46 molecule, complement regulatory protein	-	HPRD,BioGRID	10657632
CD59	16.3A5 \| 1F5 \| EJ16 \| EJ30 \| EL32 \| FLJ38134 \| FLJ92039 \| G344 \| HRF-20 \| HRF20 \| MAC-IP \| MACIF \| MEM43 \| MGC2354 \| MIC11 \| MIN1 \| MIN2 \| MIN3 \| MIRL \| MSK21 \| p18-20	CD59 molecule, complement regulatory protein	-	HPRD	12219031
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	Reconstituted Complex	BioGRID	11085988
CDCP1	CD318 \| SIMA135 \| TRASK	CUB domain containing protein 1	Src interacts with CDCP1. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human CDCP1.	BIND	15851033
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western	BioGRID	10744074
CEACAM3	CD66D \| CEA \| CGM1 \| MGC119875 \| W264 \| W282	carcinoembryonic antigen-related cell adhesion molecule 3	-	HPRD	11708798
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-Western	BioGRID	12615911
CSF1R	C-FMS \| CD115 \| CSFR \| FIM2 \| FMS	colony stimulating factor 1 receptor	Affinity Capture-Western	BioGRID	7681396
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	7513429
CTNND1	CAS \| CTNND \| KIAA0384 \| P120CAS \| P120CTN \| p120	catenin (cadherin-associated protein), delta 1	Affinity Capture-Western	BioGRID	12640114
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	12473651
DAG1	156DAG \| A3a \| AGRNR \| DAG	dystroglycan 1 (dystrophin-associated glycoprotein 1)	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	11724572
DDR2	MIG20a \| NTRKR3 \| TKT \| TYRO10	discoidin domain receptor tyrosine kinase 2	-	HPRD,BioGRID	11884411
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Affinity Capture-Western	BioGRID	12615911
DOK1	MGC117395 \| MGC138860 \| P62DOK	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	Reconstituted Complex	BioGRID	11071635
DOK4	FLJ10488	docking protein 4	-	HPRD	12730241
DOK4	FLJ10488	docking protein 4	IRS5/DOK4 interacts with Src. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Src.	BIND	12730241
DRD4	D4DR	dopamine receptor D4	D4.4 interacts with c-Src. This interaction was modeled on a demonstrated interaction between human D4.4 and chicken c-Src.	BIND	9843378
DTNA	D18S892E \| DRP3 \| DTN \| FLJ96209 \| LVNC1	dystrobrevin, alpha	-	HPRD	9701558
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with SRC enhancer.	BIND	15782160
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD,BioGRID	8878483
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	10971656
EP300	KAT3B \| p300	E1A binding protein p300	Reconstituted Complex	BioGRID	10973497
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	-	HPRD,BioGRID	9632142
EPS8	-	epidermal growth factor receptor pathway substrate 8	-	HPRD,BioGRID	10395945
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD	7542762
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Reconstituted Complex	BioGRID	11940572
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	SRC (SRC-1) interacts with the ERBB2 (HER2) promoter.	BIND	15788656
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10454579 \|11032808 \|11564893
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	Affinity Capture-Western	BioGRID	11032808
ETS1	ETS-1 \| EWSR2 \| FLJ10768	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	SRC (SRC-1) interacts with ETS1.	BIND	15788656
ETS2	ETS2IT1	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	SRC (SRC-1) interacts with ETS2.	BIND	15788656
EVL	RNB6	Enah/Vasp-like	-	HPRD,BioGRID	10945997
FARP2	FIR \| FRG \| KIAA0793 \| PLEKHC3	FERM, RhoGEF and pleckstrin domain protein 2	-	HPRD	12771149
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD	11741599
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	-	HPRD,BioGRID	10973497
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	Protein-peptide	BioGRID	9169421
GAB2	KIAA0571	GRB2-associated binding protein 2	-	HPRD,BioGRID	10391903
GAB3	-	GRB2-associated binding protein 3	-	HPRD,BioGRID	11739737
GFAP	FLJ45472	glial fibrillary acidic protein	-	HPRD	11379820
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	-	HPRD	14523024
GJA1	CX43 \| DFNB38 \| GJAL \| ODDD	gap junction protein, alpha 1, 43kDa	-	HPRD	9278444
GJA1	CX43 \| DFNB38 \| GJAL \| ODDD	gap junction protein, alpha 1, 43kDa	Cx43 interacts with v-Src. This interaction was modelled on a demonstrated interaction between rat Cx43 and human v-Src.	BIND	9278444
GJB1	CMTX \| CMTX1 \| CX32	gap junction protein, beta 1, 32kDa	GJB1 (connexin32) interacts with and prevents the activation of Src.	BIND	15782139
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	9584165
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	Biochemical Activity	BioGRID	10871840
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	11964172
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Affinity Capture-Western Reconstituted Complex	BioGRID	10458595 \|12932824
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD	10458595 \|10884433 \|12932824
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD	10884433
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	Affinity Capture-Western	BioGRID	11577104
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD,BioGRID	10777539
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	Src interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Src from an unspecified source and human hnRNPK.	BIND	8810341
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	1310678
IL6R	CD126 \| IL-6R-1 \| IL-6R-alpha \| IL6RA \| MGC104991	interleukin 6 receptor	-	HPRD	10462375
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	Reconstituted Complex	BioGRID	10636929
KCNQ5	Kv7.5	potassium voltage-gated channel, KQT-like subfamily, member 5	-	HPRD	15304482
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	1545818 \|8766817 \|10467411
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	c-Src SH3 domain interacts with Sam68 proline-rich region. This interaction was modelled on a demonstrated interaction between c-Src from an unspecified source and human Sam68.	BIND	7537265
KIFAP3	FLJ22818 \| KAP3 \| SMAP \| Smg-GDS \| dJ190I16.1	kinesin-associated protein 3	-	HPRD,BioGRID	8900189
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	Biochemical Activity	BioGRID	11854294
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	Protein-peptide	BioGRID	9169421
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	Reconstituted Complex	BioGRID	10781592
MAPK15	ERK7 \| ERK8	mitogen-activated protein kinase 15	-	HPRD	11875070
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	Biochemical Activity	BioGRID	12226752
MATK	CHK \| CTK \| DKFZp434N1212 \| HHYLTK \| HYL \| HYLTK \| Lsk \| MGC1708 \| MGC2101	megakaryocyte-associated tyrosine kinase	-	HPRD,BioGRID	7530249
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	9837958
MICAL1	DKFZp434B1517 \| FLJ11937 \| FLJ21739 \| MICAL \| MICAL-1 \| NICAL	microtubule associated monoxygenase, calponin and LIM domain containing 1	Reconstituted Complex	BioGRID	11827972
MPZL1	FLJ21047 \| PZR \| PZR1b \| PZRa \| PZRb	myelin protein zero-like 1	-	HPRD,BioGRID	11751924
MST1R	CD136 \| CDw136 \| PTK8 \| RON	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	-	HPRD	8918464
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	MUC1 interacts with c-Src.	BIND	11483589
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	-	HPRD,BioGRID	11152665 \|11483589
MYLK	DKFZp686I10125 \| FLJ12216 \| KRP \| MLCK \| MLCK1 \| MLCK108 \| MLCK210 \| MSTP083 \| MYLK1 \| smMLCK	myosin light chain kinase	-	HPRD,BioGRID	10362724
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10847592 \|11158331 \|12482968
ND2	MTND2	NADH dehydrogenase, subunit 2 (complex I)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	15069201
NPHS1	CNF \| NPHN	nephrosis 1, congenital, Finnish type (nephrin)	-	HPRD	12846735
PDE4D	DPDE3 \| HSPDE4D \| PDE4DN2 \| STRK1	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	PDE4D4 interacts with Src SH3 domain.	BIND	10571082
PDE6G	DKFZp686C0587 \| MGC125749 \| PDEG	phosphodiesterase 6G, cGMP-specific, rod, gamma	-	HPRD,BioGRID	12624098
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	PDGFR interacts with Src. This interaction was modelled on a demonstrated interaction between rat PDGFR and Src from an unknown species.	BIND	2173144
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	10858437
PELP1	HMX3 \| MNAR \| P160	proline, glutamate and leucine rich protein 1	Affinity Capture-Western	BioGRID	15466214
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	12210743
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Affinity Capture-Western	BioGRID	10487518
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11113628
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	7510703
PLD1	-	phospholipase D1, phosphatidylcholine-specific	Biochemical Activity	BioGRID	12697812
PLD2	-	phospholipase D2	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	12697812
PLSCR1	MMTRA1B	phospholipid scramblase 1	Biochemical Activity	BioGRID	12871937
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD	11834516
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10527887
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	c-Src interacts with FAK. This interaction was modeled on a demonstrated interaction between human c-Src and mouse FAK.	BIND	9148935
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western Reconstituted Complex	BioGRID	10085298 \|11980671 \|12387730 \|12558988 \|12615911
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD	7529876 \|8054685 \|10931187
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD	7529876 \|8054685
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Src interacts with tyrosine autophosphorylated FAK. This interaction was modeled on a demonstrated interaction between human Src and avian FAK.	BIND	7515480
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD	8849729 \|10777553
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	Affinity Capture-Western Reconstituted Complex	BioGRID	8849729 \|10521452 \|10777553
PTPN2	PTPT \| TC-PTP \| TCELLPTP \| TCPTP	protein tyrosine phosphatase, non-receptor type 2	PTPN2 (TCPTP) interacts with Src. This interaction was modelled on a demonstrated interaction between human PTPN2 and chicken Src.	BIND	15696169
PTPN21	PTPD1 \| PTPRL10	protein tyrosine phosphatase, non-receptor type 21	-	HPRD,BioGRID	7519780
PTPRA	HEPTP \| HLPR \| HPTPA \| HPTPalpha \| LRP \| PTPA \| PTPRL2 \| R-PTP-alpha \| RPTPA	protein tyrosine phosphatase, receptor type, A	Affinity Capture-Western	BioGRID	11923305
PXN	FLJ16691	paxillin	Reconstituted Complex	BioGRID	10085298
PXN	FLJ16691	paxillin	-	HPRD	7534286
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	7517401
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	Reconstituted Complex	BioGRID	10454579
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	1717825
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD,BioGRID	10070972
RGS16	A28-RGS14 \| A28-RGS14P \| RGS-R	regulator of G-protein signaling 16	SRC phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between SRC from an unspecified species and human RSG16.	BIND	12588871
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD,BioGRID	12454018
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Src interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human GC-GAP.	BIND	12819203
RPL10	DKFZp686J1851 \| DXS648 \| DXS648E \| FLJ23544 \| FLJ27072 \| NOV \| QM	ribosomal protein L10	Reconstituted Complex	BioGRID	12138090
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Biochemical Activity	BioGRID	16640565
RPS6KB2	KLS \| P70-beta \| P70-beta-1 \| P70-beta-2 \| S6K-beta2 \| S6K2 \| SRK \| STK14B \| p70(S6K)-beta \| p70S6Kb	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Biochemical Activity	BioGRID	16640565
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Reconstituted Complex	BioGRID	10517671
SH3BP1	-	SH3-domain binding protein 1	-	HPRD,BioGRID	1379745
SH3PXD2A	FISH \| SH3MD1	SH3 and PX domains 2A	-	HPRD	9687503
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	Shb interacts with Src. This interaction was modelled on a demonstrated interaction between human Shb and chicken Src.	BIND	7537362
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD,BioGRID	7537362
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Src interacts with Shc. This interaction was modelled on demonstrated interactions between human Src and rat Shc, and between Src from unspecified species and human Shc.	BIND	7515480 \|8939605
SKAP1	SCAP1 \| SKAP55	src kinase associated phosphoprotein 1	-	HPRD,BioGRID	9195899
SLC9A2	NHE2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	-	HPRD,BioGRID	10187839
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	-	HPRD	12145209
SMARCE1	BAF57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	-	HPRD	12145209
SNURF	-	SNRPN upstream reading frame	Phenotypic Enhancement	BioGRID	11696545
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Tyrosine phophorylated c-Src interacts with Src SH2 domain.	BIND	7683128
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	9174343
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	-	HPRD,BioGRID	9786846
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	9344858
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	8657134
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	-	HPRD	10358079
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	7513017
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD,BioGRID	10899172
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex	BioGRID	10454579
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD	12810717
TNFSF11	CD254 \| ODF \| OPGL \| OPTB2 \| RANKL \| TRANCE \| hRANKL2 \| sOdf	tumor necrosis factor (ligand) superfamily, member 11	Affinity Capture-Western	BioGRID	10635328
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	Affinity Capture-Western	BioGRID	10635328
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	Affinity Capture-Western	BioGRID	10635328
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	10635328
TRIP4	HsT17391	thyroid hormone receptor interactor 4	Affinity Capture-Western	BioGRID	10454579
TRIP6	MGC10556 \| MGC10558 \| MGC29959 \| MGC3837 \| MGC4423 \| OIP1 \| ZRP-1	thyroid hormone receptor interactor 6	-	HPRD,BioGRID	14688263
TRPC6	FLJ11098 \| FLJ14863 \| FSGS2 \| TRP6	transient receptor potential cation channel, subfamily C, member 6	-	HPRD,BioGRID	14761972
TRPV4	OTRPC4 \| TRP12 \| VR-OAC \| VRL-2 \| VRL2 \| VROAC	transient receptor potential cation channel, subfamily V, member 4	-	HPRD,BioGRID	12538589
TUB	rd5	tubby homolog (mouse)	-	HPRD	10455176
TYRO3	BYK \| Brt \| Dtk \| FLJ16467 \| RSE \| Sky \| Tif	TYRO3 protein tyrosine kinase	-	HPRD,BioGRID	7537495
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD,BioGRID	8805332
WBP11	DKFZp779M1063 \| NPWBP \| SIPP1	WW domain binding protein 11	-	HPRD	11375989
YTHDC1	KIAA1966 \| YT521 \| YT521-B	YTH domain containing 1	-	HPRD	15175272
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD	8702721
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD	8702721
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	8702721
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD	8702721

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
BIOCARTA CBL PATHWAY	13	10	All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA GABA PATHWAY	10	10	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY	32	23	All SZGR 2.0 genes in this pathway
BIOCARTA ACH PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA SPRY PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
ST G ALPHA S PATHWAY	16	11	All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY	35	29	All SZGR 2.0 genes in this pathway
ST ADRENERGIC	36	29	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
ST STAT3 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
ST INTERLEUKIN 4 PATHWAY	26	18	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID NFKAPPAB ATYPICAL PATHWAY	17	15	All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY	27	20	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY	35	27	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID FAS PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY	25	18	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID SYNDECAN 3 PATHWAY	17	15	All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY	30	25	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY	19	16	All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY	33	25	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING	14	9	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF KIT SIGNALING	17	10	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS	13	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PECAM1 INTERACTIONS	10	7	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	11	All SZGR 2.0 genes in this pathway
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	15	10	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	27	17	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1	25	16	All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION	32	26	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME CTLA4 INHIBITORY SIGNALING	21	15	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION	31	19	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1	27	15	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	12	10	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP	35	22	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN	242	165	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS	36	25	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLIFIED IN SOFT TISSUE CANCER	13	7	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP	195	138	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 UP	45	32	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP	44	30	All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE	62	38	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
MATZUK EARLY ANTRAL FOLLICLE	13	11	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP	115	73	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	1620	1626	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-141/200a	1867	1873	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1867	1873	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-149	1651	1657	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-153	1891	1897	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-203.1	1594	1601	1A,m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-203.1	1594	1601	1A,m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-378	764	770	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-9	419	425	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SRC