Gene Page: SRC

Summary
GeneID  6714
Symbol  SRC
Synonyms  ASV|SRC1|c-SRC|p60-Src
Description  v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
See related  HGNC:11283|MIM:190090|Ensembl:ENSG00000197122|HPRD:01819|
Locus tag  -
Gene type  protein-coding
Map location  20q12-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 14.4947 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RASAL10.790.78
RASGEF1A0.770.82
SLC7A40.760.83
SYN10.750.81
PRKCG0.750.82
SYN20.750.81
SLC30A30.750.77
CHRM10.750.77
TMEM1300.750.81
PNMAL20.740.77
Top 10 negatively co-expressed genes
RBMX2-0.39-0.45
KIAA1949-0.38-0.26
CSRP2-0.37-0.43
SLA-0.37-0.02
TUBB2B-0.37-0.36
SH2D2A-0.37-0.41
FABP7-0.36-0.39
ZNF435-0.36-0.24
DACT1-0.360.00
MYCN-0.36-0.03
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005070SH3/SH2 adaptor activityTAS9020193 
GO:0005515protein bindingIPI8681387 |9763511 
GO:0005524ATP bindingIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0042169SH2 domain bindingIPI8070403 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007172signal complex assemblyTAS9924018 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007243protein kinase cascadeTAS9020193 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10858437 |11124251 
GO:0005901caveolaIDA17848177 
GO:0005886plasma membraneEXP8845374 |9028946 |11124251 
|12506110 |12907686 
|15574420 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinasec-Abl interacts with Src. This interaction was modeled on a demonstrated interaction between human c-Abl and v-Src from the Rous Sarcoma virus.BIND1383690 
ADAM12MCMP | MCMPMltna | MLTN | MLTNAADAM metallopeptidase domain 12-HPRD11127814 
ADAM15MDC15ADAM metallopeptidase domain 15-HPRD11741929 
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surfaceAffinity Capture-WesternBioGRID11013230 
ADRB3BETA3ARadrenergic, beta-3-, receptor-HPRD,BioGRID11013230 
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1-HPRD,BioGRID12624098 
AFAP1AFAP | AFAP-110 | FLJ56849actin filament associated protein 1-HPRD,BioGRID9655255 
AHR-aryl hydrocarbon receptorAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID12024042 
ANKRD11ANCO-1 | LZ16 | T13ankyrin repeat domain 11-HPRD15184363 
ANXA2ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IVannexin A2-HPRD,BioGRID11106497 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Two-hybrid
BioGRID11032808 |15027889 
|15466214 
ARHGAP1CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAPRho GTPase activating protein 1-HPRD,BioGRID8253717 
ARHGAP17DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15Rho GTPase activating protein 17Reconstituted ComplexBioGRID11431473 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocatorAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID12024042 
ARR3ARRXarrestin 3, retinal (X-arrestin)-HPRD,BioGRID11877451 
ASAP1AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14PArfGAP with SH3 domain, ankyrin repeat and PH domain 1-HPRD,BioGRID9819391 
ASAP2AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1ArfGAP with SH3 domain, ankyrin repeat and PH domain 2Affinity Capture-WesternBioGRID10022920 
AXLJTK11 | UFOAXL receptor tyrosine kinase-HPRD,BioGRID9178760 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1c-Src interacts with CAS.BIND9148935 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10085298 |10487518 
|10739664 |11514617 
|12397603 |12615911 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionBCR interacts with Src. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and Src from Rous Sarcoma virus.BIND1383690 
BMXETK | PSCTK2 | PSCTK3BMX non-receptor tyrosine kinase-HPRD,BioGRID10688651 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID8910575 
CAV2CAV | MGC12294caveolin 2Reconstituted ComplexBioGRID12091389 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD8635998 
Cbl interacts with Src. This interaction was modeled on a demonstrated interaction between human Cbl and Src from unspecified species.BIND15135048 
CD2APCMS | DKFZp586H0519CD2-associated protein-HPRD10339567 
CD36CHDS7 | FAT | GP3B | GP4 | GPIV | PASIV | SCARB3CD36 molecule (thrombospondin receptor)-HPRD7521304 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)Affinity Capture-Western
Reconstituted Complex
BioGRID11084024 
CD46MCP | MGC26544 | MIC10 | TLX | TRA2.10CD46 molecule, complement regulatory protein-HPRD,BioGRID10657632 
CD5916.3A5 | 1F5 | EJ16 | EJ30 | EL32 | FLJ38134 | FLJ92039 | G344 | HRF-20 | HRF20 | MAC-IP | MACIF | MEM43 | MGC2354 | MIC11 | MIN1 | MIN2 | MIN3 | MIRL | MSK21 | p18-20CD59 molecule, complement regulatory protein-HPRD12219031 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)Reconstituted ComplexBioGRID11085988 
CDCP1CD318 | SIMA135 | TRASKCUB domain containing protein 1Src interacts with CDCP1. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human CDCP1.BIND15851033 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-WesternBioGRID10744074 
CEACAM3CD66D | CEA | CGM1 | MGC119875 | W264 | W282carcinoembryonic antigen-related cell adhesion molecule 3-HPRD11708798 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-WesternBioGRID12615911 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptorAffinity Capture-WesternBioGRID7681396 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID7513429 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1Affinity Capture-WesternBioGRID12640114 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID12473651 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
BioGRID11724572 
DDR2MIG20a | NTRKR3 | TKT | TYRO10discoidin domain receptor tyrosine kinase 2-HPRD,BioGRID11884411 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1Affinity Capture-WesternBioGRID12615911 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Reconstituted ComplexBioGRID11071635 
DOK4FLJ10488docking protein 4-HPRD12730241 
IRS5/DOK4 interacts with Src. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Src.BIND12730241 
DRD4D4DRdopamine receptor D4D4.4 interacts with c-Src. This interaction was modeled on a demonstrated interaction between human D4.4 and chicken c-Src.BIND9843378 
DTNAD18S892E | DRP3 | DTN | FLJ96209 | LVNC1dystrobrevin, alpha-HPRD9701558 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with SRC enhancer.BIND15782160 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD,BioGRID8878483 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID10971656 
EP300KAT3B | p300E1A binding protein p300Reconstituted ComplexBioGRID10973497 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD,BioGRID9632142 
EPS8-epidermal growth factor receptor pathway substrate 8-HPRD,BioGRID10395945 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD7542762 
Reconstituted ComplexBioGRID11940572 
SRC (SRC-1) interacts with the ERBB2 (HER2) promoter.BIND15788656 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-Western
Reconstituted Complex
BioGRID10454579 |11032808 
|11564893 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)Affinity Capture-WesternBioGRID11032808 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)SRC (SRC-1) interacts with ETS1.BIND15788656 
ETS2ETS2IT1v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)SRC (SRC-1) interacts with ETS2.BIND15788656 
EVLRNB6Enah/Vasp-like-HPRD,BioGRID10945997 
FARP2FIR | FRG | KIAA0793 | PLEKHC3FERM, RhoGEF and pleckstrin domain protein 2-HPRD12771149 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD11741599 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1-HPRD,BioGRID10973497 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESProtein-peptideBioGRID9169421 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID10391903 
GAB3-GRB2-associated binding protein 3-HPRD,BioGRID11739737 
GFAPFLJ45472glial fibrillary acidic protein-HPRD11379820 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD14523024 
GJA1CX43 | DFNB38 | GJAL | ODDDgap junction protein, alpha 1, 43kDa-HPRD9278444 
Cx43 interacts with v-Src. This interaction was modelled on a demonstrated interaction between rat Cx43 and human v-Src.BIND9278444 
GJB1CMTX | CMTX1 | CX32gap junction protein, beta 1, 32kDaGJB1 (connexin32) interacts with and prevents the activation of Src.BIND15782139 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID9584165 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10Biochemical ActivityBioGRID10871840 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11964172 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2AAffinity Capture-Western
Reconstituted Complex
BioGRID10458595 |12932824 
-HPRD10458595 |10884433 
|12932824 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD10884433 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)Affinity Capture-WesternBioGRID11577104 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD,BioGRID10777539 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KSrc interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Src from an unspecified source and human hnRNPK.BIND8810341 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID1310678 
IL6RCD126 | IL-6R-1 | IL-6R-alpha | IL6RA | MGC104991interleukin 6 receptor-HPRD10462375 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinaseReconstituted ComplexBioGRID10636929 
KCNQ5Kv7.5potassium voltage-gated channel, KQT-like subfamily, member 5-HPRD15304482 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID1545818 |8766817 
|10467411 
c-Src SH3 domain interacts with Sam68 proline-rich region. This interaction was modelled on a demonstrated interaction between c-Src from an unspecified source and human Sam68.BIND7537265 
KIFAP3FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1kinesin-associated protein 3-HPRD,BioGRID8900189 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)Biochemical ActivityBioGRID11854294 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologProtein-peptideBioGRID9169421 
MAP2DKFZp686I2148 | MAP2A | MAP2B | MAP2Cmicrotubule-associated protein 2Reconstituted ComplexBioGRID10781592 
MAPK15ERK7 | ERK8mitogen-activated protein kinase 15-HPRD11875070 
MAPK8IP3DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2mitogen-activated protein kinase 8 interacting protein 3Biochemical ActivityBioGRID12226752 
MATKCHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101megakaryocyte-associated tyrosine kinase-HPRD,BioGRID7530249 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)-HPRD,BioGRID9837958 
MICAL1DKFZp434B1517 | FLJ11937 | FLJ21739 | MICAL | MICAL-1 | NICALmicrotubule associated monoxygenase, calponin and LIM domain containing 1Reconstituted ComplexBioGRID11827972 
MPZL1FLJ21047 | PZR | PZR1b | PZRa | PZRbmyelin protein zero-like 1-HPRD,BioGRID11751924 
MST1RCD136 | CDw136 | PTK8 | RONmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)-HPRD8918464 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associatedMUC1 interacts with c-Src.BIND11483589 
-HPRD,BioGRID11152665 |11483589 
MYLKDKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCKmyosin light chain kinase-HPRD,BioGRID10362724 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10567404 |10847592 
|11158331 |12482968 
ND2MTND2NADH dehydrogenase, subunit 2 (complex I)Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID15069201 
NPHS1CNF | NPHNnephrosis 1, congenital, Finnish type (nephrin)-HPRD12846735 
PDE4DDPDE3 | HSPDE4D | PDE4DN2 | STRK1phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)PDE4D4 interacts with Src SH3 domain.BIND10571082 
PDE6GDKFZp686C0587 | MGC125749 | PDEGphosphodiesterase 6G, cGMP-specific, rod, gamma-HPRD,BioGRID12624098 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptidePDGFR interacts with Src. This interaction was modelled on a demonstrated interaction between rat PDGFR and Src from an unknown species.BIND2173144 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID10858437 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1Affinity Capture-WesternBioGRID15466214 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD12210743 
Affinity Capture-WesternBioGRID10487518 
PKD1PBPpolycystic kidney disease 1 (autosomal dominant)-HPRD11113628 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID7510703 
PLD1-phospholipase D1, phosphatidylcholine-specificBiochemical ActivityBioGRID12697812 
PLD2-phospholipase D2Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
BioGRID12697812 
PLSCR1MMTRA1Bphospholipid scramblase 1Biochemical ActivityBioGRID12871937 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilon-HPRD11834516 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID10527887 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2c-Src interacts with FAK. This interaction was modeled on a demonstrated interaction between human c-Src and mouse FAK.BIND9148935 
Affinity Capture-Western
Reconstituted Complex
BioGRID10085298 |11980671 
|12387730 |12558988 
|12615911 
-HPRD7529876 |8054685 
|10931187 
-HPRD7529876 |8054685 
Src interacts with tyrosine autophosphorylated FAK. This interaction was modeled on a demonstrated interaction between human Src and avian FAK.BIND7515480 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD8849729 |10777553 
Affinity Capture-Western
Reconstituted Complex
BioGRID8849729 |10521452 
|10777553 
PTPN2PTPT | TC-PTP | TCELLPTP | TCPTPprotein tyrosine phosphatase, non-receptor type 2PTPN2 (TCPTP) interacts with Src. This interaction was modelled on a demonstrated interaction between human PTPN2 and chicken Src.BIND15696169 
PTPN21PTPD1 | PTPRL10protein tyrosine phosphatase, non-receptor type 21-HPRD,BioGRID7519780 
PTPRAHEPTP | HLPR | HPTPA | HPTPalpha | LRP | PTPA | PTPRL2 | R-PTP-alpha | RPTPAprotein tyrosine phosphatase, receptor type, AAffinity Capture-WesternBioGRID11923305 
PXNFLJ16691paxillinReconstituted ComplexBioGRID10085298 
-HPRD7534286 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID7517401 
RARANR1B1 | RARretinoic acid receptor, alphaReconstituted ComplexBioGRID10454579 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID1717825 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogene-HPRD,BioGRID10070972 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16SRC phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between SRC from an unspecified species and human RSG16.BIND12588871 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12454018 
Src interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human GC-GAP.BIND12819203 
RPL10DKFZp686J1851 | DXS648 | DXS648E | FLJ23544 | FLJ27072 | NOV | QMribosomal protein L10Reconstituted ComplexBioGRID12138090 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Biochemical ActivityBioGRID16640565 
RPS6KB2KLS | P70-beta | P70-beta-1 | P70-beta-2 | S6K-beta2 | S6K2 | SRK | STK14B | p70(S6K)-beta | p70S6Kbribosomal protein S6 kinase, 70kDa, polypeptide 2Biochemical ActivityBioGRID16640565 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaReconstituted ComplexBioGRID10517671 
SH3BP1-SH3-domain binding protein 1-HPRD,BioGRID1379745 
SH3PXD2AFISH | SH3MD1SH3 and PX domains 2A-HPRD9687503 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein BShb interacts with Src. This interaction was modelled on a demonstrated interaction between human Shb and chicken Src.BIND7537362 
-HPRD,BioGRID7537362 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Src interacts with Shc. This interaction was modelled on demonstrated interactions between human Src and rat Shc, and between Src from unspecified species and human Shc.BIND7515480 |8939605 
SKAP1SCAP1 | SKAP55src kinase associated phosphoprotein 1-HPRD,BioGRID9195899 
SLC9A2NHE2solute carrier family 9 (sodium/hydrogen exchanger), member 2-HPRD,BioGRID10187839 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1-HPRD12145209 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1-HPRD12145209 
SNURF-SNRPN upstream reading framePhenotypic EnhancementBioGRID11696545 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Tyrosine phophorylated c-Src interacts with Src SH2 domain.BIND7683128 
-HPRD9174343 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD,BioGRID9786846 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID9344858 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID8657134 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD10358079 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID7513017 
SYN1SYN1a | SYN1b | SYNIsynapsin I-HPRD,BioGRID10899172 
THRBERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)Reconstituted ComplexBioGRID10454579 
TIAM1FLJ36302T-cell lymphoma invasion and metastasis 1-HPRD12810717 
TNFSF11CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdftumor necrosis factor (ligand) superfamily, member 11Affinity Capture-WesternBioGRID10635328 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1Affinity Capture-WesternBioGRID10635328 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3Affinity Capture-WesternBioGRID10635328 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID10635328 
TRIP4HsT17391thyroid hormone receptor interactor 4Affinity Capture-WesternBioGRID10454579 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6-HPRD,BioGRID14688263 
TRPC6FLJ11098 | FLJ14863 | FSGS2 | TRP6transient receptor potential cation channel, subfamily C, member 6-HPRD,BioGRID14761972 
TRPV4OTRPC4 | TRP12 | VR-OAC | VRL-2 | VRL2 | VROACtransient receptor potential cation channel, subfamily V, member 4-HPRD,BioGRID12538589 
TUBrd5tubby homolog (mouse)-HPRD10455176 
TYRO3BYK | Brt | Dtk | FLJ16467 | RSE | Sky | TifTYRO3 protein tyrosine kinase-HPRD,BioGRID7537495 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID8805332 
WBP11DKFZp779M1063 | NPWBP | SIPP1WW domain binding protein 11-HPRD11375989 
YTHDC1KIAA1966 | YT521 | YT521-BYTH domain containing 1-HPRD15175272 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD8702721 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD8702721 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD8702721 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD8702721 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
BIOCARTA_SRCRPTP_PATHWAY 119All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_GABA_PATHWAY 1010All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_ACH_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_UCALPAIN_PATHWAY 1811All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
ST_G_ALPHA_S_PATHWAY 1611All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
ST_STAT3_PATHWAY 1110All SZGR genes in this pathway
ST_INTERLEUKIN_4_PATHWAY 2618All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_NFKAPPAB_ATYPICAL_PATHWAY 1715All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
PID_INTEGRIN_A9B1_PATHWAY 2518All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY 4435All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY 4135All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY 3631All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY 1916All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 149All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_REGULATION_OF_KIT_SIGNALING 1710All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_P38MAPK_EVENTS 1312All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_PECAM1_INTERACTIONS 107All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 1511All SZGR genes in this pathway
REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ 1510All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 2516All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION 3226All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_CTLA4_INHIBITORY_SIGNALING 2115All SZGR genes in this pathway
REACTOME_SIGNAL_AMPLIFICATION 3119All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING 4130All SZGR genes in this pathway
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 1311All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1 2715All SZGR genes in this pathway
REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS 1210All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_UP 3522All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
HEIDENBLAD_AMPLIFIED_IN_SOFT_TISSUE_CANCER 137All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_UP 4532All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
BILD_SRC_ONCOGENIC_SIGNATURE 6238All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
MATZUK_EARLY_ANTRAL_FOLLICLE 1311All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137162016261Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-141/200a18671873m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-14916511657m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15318911897m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-203.1159416011A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-3787647701Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-94194251Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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