Gene Page: TAP2

Summary
GeneID  6891
Symbol  TAP2
Synonyms  ABC18|ABCB3|APT2|D6S217E|PSF2|RING11
Description  transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
See related  HGNC:44|MIM:170261|Ensembl:ENSG00000204267|HPRD:01360|
Locus tag  DAAP-57C1.2
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizophrenic]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS12047747 
GO:0004409homoaconitate hydratase activityNAS1946428 
GO:0005215transporter activityIDA10835348 
GO:0005215transporter activityIEA-
GO:0015433peptide antigen-transporting ATPase activityNAS12047747 
GO:0016887ATPase activityIEA-
GO:0042288MHC class I protein bindingNAS12047747 
GO:0042301phosphate bindingNAS11532960 
GO:0015198oligopeptide transporter activityIEA-
GO:0015197peptide transporter activityIEA-
GO:0042605peptide antigen bindingNAS11133832 
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEA-
GO:0046982protein heterodimerization activityIPI11133832 
GO:0046982protein heterodimerization activityISS-
GO:0046980tapasin bindingIPI12047747 
GO:0046980tapasin bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyNAS12047747 
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class INAS11532960 
GO:0006955immune responseIEA-
GO:0006857oligopeptide transportIEA-
GO:0006886intracellular protein transportIMP11133832 
GO:0006886intracellular protein transportISS-
GO:0015833peptide transportIEA-
GO:0046967cytosol to ER transportNAS11133832 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS11133832 
GO:0005788endoplasmic reticulum lumenIMP11133832 
GO:0005788endoplasmic reticulum lumenISS-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusIDA18029348 
GO:0005783endoplasmic reticulumIDA18029348 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS1946428 
GO:0042825TAP complexNAS12202157 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HLA-CD6S204 | FLJ27082 | HLA-Cw | HLA-Cw12 | HLA-JY3 | HLC-C | PSORS1major histocompatibility complex, class I, C-HPRD,BioGRID9551969 
HLA-GMHC-Gmajor histocompatibility complex, class I, G-HPRD,BioGRID9103419 
TAP1ABC17 | ABCB2 | APT1 | D6S114E | FLJ26666 | FLJ41500 | PSF1 | RING4 | TAP1*0102N | TAP1Ntransporter 1, ATP-binding cassette, sub-family B (MDR/TAP)Reconstituted ComplexBioGRID11381133 
TAPBPNGS17 | TAPA | TPN | TPSN | tapasinTAP binding protein (tapasin)-HPRD,BioGRID12213826 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ABC_TRANSPORTERS 4429All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 2117All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FLI1 98All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN 5132All SZGR genes in this pathway
JAIN_NFKB_SIGNALING 7544All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_UP 1210All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP 1711All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP 5838All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_UP 2214All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-37016761682m8hsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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