Gene Page: TF

Summary ?
GeneID7018
SymbolTF
SynonymsHEL-S-71p|PRO1557|PRO2086|TFQTL1
Descriptiontransferrin
ReferenceMIM:190000|HGNC:HGNC:11740|Ensembl:ENSG00000091513|HPRD:01811|Vega:OTTHUMG00000150356
Gene typeprotein-coding
Map location3q22.1
Pascal p-value0.351
Sherlock p-value0.241
Fetal beta-3.71
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0982 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs18675043133410661null1.679TFnull

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7830259chr814087643TF70180.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HADHB0.840.85
CYP2J20.840.85
HSPB80.820.86
CSRP10.810.83
SDC40.810.82
TMBIM10.800.86
CKMT20.800.75
EFEMP10.800.78
STOM0.790.82
GRAMD30.790.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.58-0.55
CRMP1-0.57-0.57
GPRIN1-0.57-0.58
ZNF821-0.56-0.56
C19orf57-0.56-0.57
NR2C2AP-0.56-0.62
MPP3-0.56-0.58
AC011491.1-0.56-0.65
GMIP-0.56-0.57
HN1-0.55-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008199ferric iron bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006826iron ion transportIEA-
GO:0006811ion transportIEA-
GO:0006879cellular iron ion homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005576extracellular regionNAS14718574 
GO:0005739mitochondrionIDA18029348 
GO:0005768endosomeIEA-
GO:0030139endocytic vesicleIDA15229288 |15292400 
GO:0030139endocytic vesicleIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulin-HPRD,BioGRID9312001 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD,BioGRID9312001 
CUBNFLJ90055 | FLJ90747 | IFCR | MGA1 | gp280cubilin (intrinsic factor-cobalamin receptor)Transferrin interacts with Cubilin.BIND11606717 
FNBP1FBP17 | KIAA0554 | MGC126804formin binding protein 1Co-localizationBioGRID15252009 
IGF1IGFIinsulin-like growth factor 1 (somatomedin C)Reconstituted ComplexBioGRID11749962 
IGF2C11orf43 | FLJ22066 | FLJ44734 | INSIGF | pp9974insulin-like growth factor 2 (somatomedin A)Reconstituted ComplexBioGRID11749962 
IGFBP1AFBP | IBP1 | IGF-BP25 | PP12 | hIGFBP-1insulin-like growth factor binding protein 1-HPRD11297622 
IGFBP2IBP2 | IGF-BP53insulin-like growth factor binding protein 2, 36kDa-HPRD11297622 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3-HPRD,BioGRID11297622 |11749962 
IGFBP4BP-4 | HT29-IGFBP | IBP4 | IGFBP-4insulin-like growth factor binding protein 4-HPRD11297622 
IGFBP5IBP5insulin-like growth factor binding protein 5-HPRD11297622 
IGFBP6IBP6insulin-like growth factor binding protein 6-HPRD11297622 
TFR2HFE3 | MGC126368 | TFRC2transferrin receptor 2-HPRD,BioGRID11027676 
TFRCCD71 | TFR | TFR1 | TRFRtransferrin receptor (p90, CD71)Tf interacts with TfR.BIND15525538 
TFRCCD71 | TFR | TFR1 | TRFRtransferrin receptor (p90, CD71)Reconstituted ComplexBioGRID11027676 
TFRCCD71 | TFR | TFR1 | TRFRtransferrin receptor (p90, CD71)-HPRD6268632 
TUBB3MC1R | TUBB4 | beta-4tubulin, beta 3Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ST WNT CA2 CYCLIC GMP PATHWAY 2014All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 6652All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME IRON UPTAKE AND TRANSPORT 3618All SZGR 2.0 genes in this pathway
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2510All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 17582All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING DN 4937All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR DN 4634All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER D 3714All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP 3532All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 8164All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 3632All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE 4529All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 6647All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM DN 5734All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 13483All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 DN 5132All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 8950All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway