SZGR2

Summary ?

GeneID	7187
Symbol	TRAF3
Synonyms	CAP-1\|CAP1\|CD40bp\|CRAF1\|IIAE5\|LAP1
Description	TNF receptor associated factor 3
Reference	MIM:601896\|HGNC:HGNC:12033\|Ensembl:ENSG00000131323\|HPRD:03539\|Vega:OTTHUMG00000171902
Gene type	protein-coding
Map location	14q32.32
Pascal p-value	0.035
Fetal beta	-0.427
eGene	Cerebellum Meta
Support	G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
Expression	Meta-analysis of gene expression	P value: 1.706

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	TAS		7530216 \|7533327
GO:0005515	protein binding	IPI		7527023 \|9162022 \|10791955 \|11035039 \|12005438 \|15280356
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006917	induction of apoptosis	TAS		10799510
GO:0007165	signal transduction	TAS		7530216
GO:0042981	regulation of apoptosis	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	-	HPRD	11950878
CAP1	CAP \| CAP1-PEN	CAP, adenylate cyclase-associated protein 1 (yeast)	-	HPRD	8761950
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11261798
CD27	MGC20393 \| S152 \| T14 \| TNFRSF7 \| Tp55	CD27 molecule	-	HPRD,BioGRID	9582383 \|9794406
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	-	HPRD	7527023 \|7530216 \|7533327 \|10984535
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7527023 \|9384571 \|9990007 \|10984535
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	CD40 interacts with TRAF3.	BIND	10352240
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	-	HPRD	7527023 \|7533327 \|10984535
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	Affinity Capture-Western	BioGRID	10837247
EDA2R	EDA-A2R \| EDAA2R \| TNFRSF27 \| XEDAR	ectodysplasin A2 receptor	Affinity Capture-Western	BioGRID	12270937
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
LTBR	CD18 \| D12S370 \| LT-BETA-R \| TNF-R-III \| TNFCR \| TNFR-RP \| TNFR2-RP \| TNFRSF3	lymphotoxin beta receptor (TNFR superfamily, member 3)	-	HPRD,BioGRID	9122217
LTBR	CD18 \| D12S370 \| LT-BETA-R \| TNF-R-III \| TNFCR \| TNFR-RP \| TNFR2-RP \| TNFRSF3	lymphotoxin beta receptor (TNFR superfamily, member 3)	TRAF3 interacts with LTBR.	BIND	12571250
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD	8626767
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	11278268
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	NIK interacts with TRAF3. This interaction was modeled on a demonstrated interaction between human NIK and TRAF3 from an unspecified species.	BIND	9275204
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	Affinity Capture-Western	BioGRID	9774977
NGFR	CD271 \| Gp80-LNGFR \| TNFRSF16 \| p75(NTR) \| p75NTR	nerve growth factor receptor (TNFR superfamily, member 16)	Affinity Capture-Western	BioGRID	10514511
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	in vitro in vivo Two-hybrid	BioGRID	10781837
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	8612133
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	-	HPRD	10557073
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	10635328
TANK	I-TRAF \| TRAF2	TRAF family member-associated NFKB activator	-	HPRD,BioGRID	8710854
TNFRSF11A	CD265 \| FEO \| LOH18CR1 \| ODFR \| OFE \| OPTB7 \| OSTS \| PDB2 \| RANK \| TRANCER	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	-	HPRD,BioGRID	9774460 \|9852070 \|10025951
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	-	HPRD	11728344
TNFRSF14	ATAR \| HVEA \| HVEM \| LIGHTR \| TR2	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	-	HPRD,BioGRID	9162022
TNFRSF17	BCM \| BCMA \| CD269	tumor necrosis factor receptor superfamily, member 17	-	HPRD,BioGRID	10903733
TNFRSF18	AITR \| GITR \| GITR-D	tumor necrosis factor receptor superfamily, member 18	-	HPRD,BioGRID	10037686
TNFRSF19	TAJ \| TAJ-alpha \| TRADE \| TROY	tumor necrosis factor receptor superfamily, member 19	-	HPRD,BioGRID	10809768
TNFRSF4	ACT35 \| CD134 \| OX40 \| TXGP1L	tumor necrosis factor receptor superfamily, member 4	-	HPRD	9418902
TNFRSF8	CD30 \| D1S166E \| KI-1	tumor necrosis factor receptor superfamily, member 8	CRAF1 interacts with CD30.	BIND	8662842
TNFRSF8	CD30 \| D1S166E \| KI-1	tumor necrosis factor receptor superfamily, member 8	-	HPRD,BioGRID	8943059
TNFRSF9	4-1BB \| CD137 \| CDw137 \| ILA \| MGC2172	tumor necrosis factor receptor superfamily, member 9	-	HPRD,BioGRID	9464265
TNFSF14	CD258 \| HVEML \| LIGHT \| LTg \| TR2	tumor necrosis factor (ligand) superfamily, member 14	Affinity Capture-MS Affinity Capture-Western	BioGRID	12571250
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	8565075
TRAF3IP1	DKFZp434F124 \| MIP-T3 \| MIPT3	TNF receptor-associated factor 3 interacting protein 1	-	HPRD,BioGRID	10791955
TRAF3IP2	ACT1 \| C6orf2 \| C6orf4 \| C6orf5 \| C6orf6 \| CIKS \| DKFZp586G0522 \| MGC3581	TRAF3 interacting protein 2	-	HPRD,BioGRID	12089335
TRAF3IP3	DJ434O14.3 \| FLJ44151 \| MGC117354 \| MGC163289 \| T3JAM	TRAF3 interacting protein 3	-	HPRD	14572659
TRIM37	KIAA0898 \| MUL \| POB1 \| TEF3	tripartite motif-containing 37	-	HPRD,BioGRID	11279055
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	Affinity Capture-Western	BioGRID	10764746
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	-	HPRD,BioGRID	11279055

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA CD40 PATHWAY	15	13	All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR2 PATHWAY	18	15	All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY	32	25	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY	31	26	All SZGR 2.0 genes in this pathway
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	14	10	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	14	7	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	31	19	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP	206	111	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN	50	36	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2	30	23	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN	77	49	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE UP	53	35	All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS	183	115	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP	77	52	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP	225	139	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN UP	19	12	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN	52	33	All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP	37	31	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2	473	224	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP	156	92	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-25/32/92/363/367	461	467	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-494	470	476	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: TRAF3