Gene Page: UBE2I

Summary
GeneID  7329
Symbol  UBE2I
Synonyms  C358B7.1|P18|UBC9
Description  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
See related  HGNC:12485|MIM:601661|Ensembl:ENSG00000103275|HPRD:09045|
Locus tag  -
Gene type  protein-coding
Map location  16p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0725 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TRA2B0.920.89
DKC10.910.90
SFRS30.910.89
EIF4A30.900.90
MED170.900.91
MCM60.900.91
UBE2I0.900.90
NUP1070.890.91
ZIK10.890.88
SFRS70.890.89
Top 10 negatively co-expressed genes
HLA-F-0.69-0.76
MT-CO2-0.68-0.81
AF347015.33-0.68-0.81
AF347015.27-0.68-0.80
AF347015.31-0.67-0.80
MT-CYB-0.66-0.79
TINAGL1-0.66-0.75
AIFM3-0.65-0.72
AF347015.8-0.65-0.80
PTH1R-0.65-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9885291 |12072434 |14516784 
GO:0016874ligase activityIEA-
GO:0019787small conjugating protein ligase activityIEA-
GO:0043398HLH domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006511ubiquitin-dependent protein catabolic processTAS8565643 
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0007059chromosome segregationIEA-
GO:0051246regulation of protein metabolic processIEA-
GO:0051301cell divisionIEA-
GO:0043687post-translational protein modificationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000795synaptonemal complexTAS8610150 
GO:0005634nucleusIEA-
GO:0016605PML bodyIDA9885291 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1-HPRD,BioGRID12110916 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Phenotypic Enhancement
Two-hybrid
BioGRID10383460 
-HPRD8798622 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2-HPRD,BioGRID9488727 
BLMHBH | BMHbleomycin hydrolaseAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9855622 
C18orf25ARKL1 | MGC12909 | MGC87799chromosome 18 open reading frame 25Two-hybridBioGRID16189514 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)Ubc9 interacts with Pc2.BIND15592428 
CEBPEC/EBP-epsilon | CRP1CCAAT/enhancer binding protein (C/EBP), epsilonC/EBP-epsilon interacts with UBE2I.BIND15588942 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3-HPRD,BioGRID14609633 
Ubc9 interacts with CHD3.BIND14609633 
CHMP4BC20orf178 | CHMP4A | CTPP3 | SNF7 | SNF7-2 | Shax1 | dJ553F4.4chromatin modifying protein 4BTwo-hybridBioGRID16189514 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseBiochemical ActivityBioGRID11853669 
DACH1DACH | FLJ10138dachshund homolog 1 (Drosophila)-HPRD,BioGRID11025202 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinDaxx interacts with Ubc9.BIND11112409 
Biochemical Activity
Two-hybrid
BioGRID11112409 |18691969 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alpha-HPRD,BioGRID14752048 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 betaDnmt3b interacts with Ubc9.BIND11735126 
-HPRD,BioGRID11735126 
EP300KAT3B | p300E1A binding protein p300-HPRD8824223 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER-alpha interacts with an unspecified isoform of Ubc9.BIND15666801 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)-HPRD,BioGRID9333025 
ETV6TEL | TEL/ABLets variant 6-HPRD10377438 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD,BioGRID9257699 
FHITAP3Aase | FRA3Bfragile histidine triad gene-HPRD,BioGRID11085938 
FMR1FMRP | FRAXA | MGC87458 | POF | POF1fragile X mental retardation 1-HPRD,BioGRID11367701 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Biochemical ActivityBioGRID18691969 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrateTwo-hybridBioGRID16189514 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2Ubc9 with HIPK2.BIND14609633 
Two-hybridBioGRID14609633 
-HPRD10535925 
HNRNPCC1 | C2 | HNRNP | HNRPC | MGC104306 | MGC105117 | MGC117353 | MGC131677 | SNRPCheterogeneous nuclear ribonucleoprotein C (C1/C2)Two-hybridBioGRID16189514 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KTwo-hybridBioGRID16189514 
HSF2MGC117376 | MGC156196 | MGC75048heat shock transcription factor 2Two-hybridBioGRID11278381 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)Two-hybridBioGRID16189514 
IKZF3AIO | AIOLOS | ZNFN1A3IKAROS family zinc finger 3 (Aiolos)Two-hybridBioGRID16189514 
IPO13IMP13 | KAP13 | KIAA0724 | RANBP13importin 13-HPRD,BioGRID11447110 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID8733011 
KCNK1DPK | HOHO | K2p1.1 | KCNO1 | TWIK-1 | TWIK1potassium channel, subfamily K, member 1K2P1 interacts with Ubc-9.BIND15820677 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1Reconstituted Complex
Two-hybrid
BioGRID9563508 
MAPK1IP1LC14orf32 | MGC23138 | MISS | c14_5346mitogen-activated protein kinase 1 interacting protein 1-likeTwo-hybridBioGRID16189514 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factor-HPRD,BioGRID10694430 
MYBCmyb | c-myb | c-myb_CDS | efgv-myb myeloblastosis viral oncogene homolog (avian)-HPRD11779867 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD11812797 
NUDCD3KIAA1068 | NudCLNudC domain containing 3Two-hybridBioGRID16189514 
PDLIM7LMP1PDZ and LIM domain 7 (enigma)Two-hybridBioGRID16189514 
PDZK1CAP70 | CLAMP | NHERF3 | PDZD1PDZ domain containing 1Two-hybridBioGRID14531806 
PHC1EDR1 | HPH1 | RAE28polyhomeotic homolog 1 (Drosophila)Two-hybridBioGRID16189514 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1Ubc9 interacts with PIAS1.BIND14609633 
-HPRD12177000 
Reconstituted Complex
Two-hybrid
BioGRID11583632 |12356736 
|14609633 
PIAS2MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | mizprotein inhibitor of activated STAT, 2Two-hybridBioGRID14609633 |16189514 
Ubc9 interacts with PIASxb-eta.BIND14609633 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaBiochemical ActivityBioGRID18691969 
PPM1JDKFZp434P1514 | FLJ35951 | MGC19531 | MGC90149 | PP2CZ | PP2Czeta | PPP2CZprotein phosphatase 1J (PP2C domain containing)-HPRD,BioGRID12633878 
PTEN10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1phosphatase and tensin homologAffinity Capture-WesternBioGRID12620973 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)-HPRD,BioGRID8610150 
RAD52-RAD52 homolog (S. cerevisiae)Two-hybridBioGRID8921390 
RAD54BFSBP | RDH54RAD54 homolog B (S. cerevisiae)Two-hybridBioGRID16189514 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2Ubc9 interacts with RanBP2.BIND15608651 
RanBP2 interacts with Ubc9.BIND15378033 
-HPRD,BioGRID12192048 
RANGAP1Fug1 | KIAA1835 | MGC20266 | SDRan GTPase activating protein 1Affinity Capture-MS
Biochemical Activity
Reconstituted Complex
BioGRID12924945 |17353931 
|18691969 
Unspecified isoform of UBC9 conjugated with SUMO-1 sumoylates RanGAP1. This interaction was modeled on a demonstrated interaction between UBC9 from an unspecified species and RanGAP1 from an unspecified species.BIND15546615 
-HPRD11853669 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1RB1 (pRb) interacts with, and is sumoylated by, an unspecified isoform of UBE2I (Ubc9).BIND15806172 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2Two-hybridBioGRID16189514 
SAE1AOS1 | FLJ3091 | HSPC140 | SUA1SUMO1 activating enzyme subunit 1Affinity Capture-MSBioGRID17353931 
SALL1HSAL1 | TBS | ZNF794sal-like 1 (Drosophila)SALL1 interacts with UBE2I.BIND12200128 
-HPRD,BioGRID12200128 
SATB1-SATB homeobox 1Two-hybridBioGRID16189514 
SCNN1AENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1sodium channel, nonvoltage-gated 1 alpha-HPRD,BioGRID14556380 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)Ubc9 interacts with Siah-1.BIND9334332 
hSiah1 interacts with Ubc9.BIND9334332 
SIAH2hSiah2seven in absentia homolog 2 (Drosophila)hSiah2 interacts with Ubc9.BIND9334332 
Ubc9 interacts with Siah-2.BIND9334332 
SLC2A1DYT17 | DYT18 | GLUT | GLUT1 | MGC141895 | MGC141896 | PEDsolute carrier family 2 (facilitated glucose transporter), member 1-HPRD11842083 
SLC2A4GLUT4solute carrier family 2 (facilitated glucose transporter), member 4-HPRD11842083 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Two-hybridBioGRID16189514 
SP100DKFZp686E07254 | FLJ00340 | FLJ34579SP100 nuclear antigenBiochemical Activity
Reconstituted Complex
BioGRID18691969 
SREBF1SREBP-1c | SREBP1 | bHLHd1sterol regulatory element binding transcription factor 1-HPRD,BioGRID12615929 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2-HPRD,BioGRID12615929 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD12356736 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)-HPRD,BioGRID12924945 
Ubc9 interacts with SUMO1.BIND15592428 
hUbc9 interacts with SUMO-1.BIND9920803 
SUMO2HSMT3 | MGC117191 | SMT3B | SMT3H2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-HPRD12924945 
SUMO3SMT3A | SMT3H1 | SUMO-3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
-HPRD12924945 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)Reconstituted Complex
Two-hybrid
BioGRID10497239 
TDG-thymine-DNA glycosylaseBiochemical ActivityBioGRID18691969 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID9563508 
TOP1TOPItopoisomerase (DNA) I-HPRD,BioGRID10759568 
TOPORSLUN | P53BP3 | RP31 | TP53BPLtopoisomerase I binding, arginine/serine-rich-HPRD,BioGRID14516784 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID8921390 
p53 interacts with Ubc9. This interaction was modelled on a demonstrated interaction between p53 from human and Ubc9 from an unspecified species.BIND10788439 
UBE2I interacts with TP53. This interaction was modelled on a demonstrated interaction between D. melanogaster Lwr (DmUbc9) and p53 from an unspecified species.BIND9514881 
TP73P73tumor protein p73Two-hybridBioGRID10961991 
TRAF4CART1 | MLN62 | RNF83TNF receptor-associated factor 4TRAF4 interacts with UBC9.BIND12023963 
TRIM29ATDC | FLJ36085tripartite motif-containing 29Two-hybridBioGRID16189514 
TRIM54MURF | MURF-3 | RNF30tripartite motif-containing 54Two-hybridBioGRID11927605 
TRIM55MURF-2 | RNF29tripartite motif-containing 55Two-hybridBioGRID11927605 
TRIM63FLJ32380 | IRF | MURF1 | MURF2 | RNF28 | SMRZtripartite motif-containing 63Two-hybridBioGRID11927605 
TTRAPAD022 | EAP2 | MGC111021 | MGC9099 | dJ30M3.3TRAF and TNF receptor associated proteinTwo-hybridBioGRID14609633 
Ubc9 interacts with TTRAP.BIND14609633 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2Affinity Capture-MS
Biochemical Activity
BioGRID17353931 |18691969 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID8610150 
UBE2KDKFZp564C1216 | DKFZp686J24237 | E2-25K | HIP2 | HYPG | LIGubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)Biochemical ActivityBioGRID18691969 
UCHL1PARK5 | PGP9.5 | Uch-L1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Two-hybridBioGRID12082530 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
WT1GUD | WAGR | WIT-2 | WT33Wilms tumor 1-HPRD,BioGRID8798754 
ZBED1ALTE | DREF | KIAA0785 | TRAMP | hDREFzinc finger, BED-type containing 1Two-hybridBioGRID16189514 
ZNF451COASTER | FLJ23421 | FLJ53246 | FLJ90693 | KIAA0576 | KIAA1702 | MGC26701 | dJ417I1.1zinc finger protein 451Two-hybridBioGRID16189514 
ZNF646KIAA0296zinc finger protein 646Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_RANBP2_PATHWAY 1111All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_MEIOTIC_SYNAPSIS 7357All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 12049All SZGR genes in this pathway
NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER 9460All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1 7245All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1882935m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-200bc/429256262m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-30-5p52591A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-324-5p3293361A,m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-4105495551Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-485-5p4534591Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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