Gene Page: HIST1H3A
Summary ?
| GeneID | 8350 |
| Symbol | HIST1H3A |
| Synonyms | H3/A|H3FA |
| Description | histone cluster 1, H3a |
| Reference | MIM:602810|HGNC:HGNC:4766|Ensembl:ENSG00000275714|HPRD:04155|Vega:OTTHUMG00000014418 |
| Gene type | protein-coding |
| Map location | 6p22.2 |
| Pascal p-value | 1E-12 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| GGA3 | 0.89 | 0.92 |
| POM121 | 0.89 | 0.92 |
| GAK | 0.89 | 0.91 |
| FAM168B | 0.89 | 0.92 |
| RAI1 | 0.89 | 0.90 |
| C12orf53 | 0.89 | 0.90 |
| ZNF335 | 0.88 | 0.90 |
| MED15 | 0.88 | 0.91 |
| WDTC1 | 0.88 | 0.90 |
| RPAP1 | 0.88 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.67 | -0.73 |
| AF347015.31 | -0.66 | -0.66 |
| MT-CO2 | -0.64 | -0.65 |
| GNG11 | -0.63 | -0.70 |
| C1orf54 | -0.62 | -0.74 |
| AF347015.8 | -0.61 | -0.63 |
| AL139819.3 | -0.61 | -0.66 |
| HIGD1B | -0.60 | -0.63 |
| SYCP3 | -0.60 | -0.73 |
| MT-CYB | -0.60 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | 140 | 100 | All SZGR 2.0 genes in this pathway |
| REACTOME MEIOSIS | 116 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL I TRANSCRIPTION | 89 | 64 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 122 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL I PROMOTER OPENING | 62 | 49 | All SZGR 2.0 genes in this pathway |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 132 | 101 | All SZGR 2.0 genes in this pathway |
| REACTOME MEIOTIC RECOMBINATION | 86 | 62 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| REACTOME AMYLOIDS | 83 | 63 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |