Gene Page: CEP19
Summary ?
| GeneID | 84984 |
| Symbol | CEP19 |
| Synonyms | C3orf34|MOSPGF |
| Description | centrosomal protein 19kDa |
| Reference | MIM:615586|HGNC:HGNC:28209|Ensembl:ENSG00000174007|HPRD:17488|Vega:OTTHUMG00000153933 |
| Gene type | protein-coding |
| Map location | 3q29 |
| Pascal p-value | 0.369 |
| Sherlock p-value | 0.082 |
| Fetal beta | -0.241 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10211183 | chr2 | 60302291 | C3orf34 | 84984 | 0.19 | trans | ||
| rs2840033 | chr5 | 124609648 | C3orf34 | 84984 | 0.07 | trans | ||
| rs1463626 | 3 | 196454560 | CEP19 | ENSG00000174007.7 | 3.058E-7 | 0.02 | -15396 | gtex_brain_ba24 |
| rs9849684 | 3 | 196433031 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 6133 | gtex_brain_putamen_basal |
| rs7646550 | 3 | 196433421 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 5743 | gtex_brain_putamen_basal |
| rs9840915 | 3 | 196433441 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 5723 | gtex_brain_putamen_basal |
| rs7616240 | 3 | 196433623 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 5541 | gtex_brain_putamen_basal |
| rs71621289 | 3 | 196433653 | CEP19 | ENSG00000174007.7 | 1.777E-8 | 0 | 5511 | gtex_brain_putamen_basal |
| rs7647102 | 3 | 196433984 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 5180 | gtex_brain_putamen_basal |
| rs9843349 | 3 | 196435138 | CEP19 | ENSG00000174007.7 | 2.38E-8 | 0 | 4026 | gtex_brain_putamen_basal |
| rs55901490 | 3 | 196435331 | CEP19 | ENSG00000174007.7 | 2.352E-8 | 0 | 3833 | gtex_brain_putamen_basal |
| rs6776064 | 3 | 196435534 | CEP19 | ENSG00000174007.7 | 2.354E-8 | 0 | 3630 | gtex_brain_putamen_basal |
| rs6785167 | 3 | 196435986 | CEP19 | ENSG00000174007.7 | 2.354E-8 | 0 | 3178 | gtex_brain_putamen_basal |
| rs6809954 | 3 | 196435994 | CEP19 | ENSG00000174007.7 | 1.585E-8 | 0 | 3170 | gtex_brain_putamen_basal |
| rs11919448 | 3 | 196436629 | CEP19 | ENSG00000174007.7 | 2.402E-8 | 0 | 2535 | gtex_brain_putamen_basal |
| rs9834389 | 3 | 196437004 | CEP19 | ENSG00000174007.7 | 4.469E-8 | 0 | 2160 | gtex_brain_putamen_basal |
| rs9858181 | 3 | 196437197 | CEP19 | ENSG00000174007.7 | 1.364E-7 | 0 | 1967 | gtex_brain_putamen_basal |
| rs9875088 | 3 | 196437309 | CEP19 | ENSG00000174007.7 | 4.202E-8 | 0 | 1855 | gtex_brain_putamen_basal |
| rs7628991 | 3 | 196437936 | CEP19 | ENSG00000174007.7 | 1.12E-7 | 0 | 1228 | gtex_brain_putamen_basal |
| rs6583170 | 3 | 196438428 | CEP19 | ENSG00000174007.7 | 8.557E-7 | 0 | 736 | gtex_brain_putamen_basal |
| rs9863311 | 3 | 196440527 | CEP19 | ENSG00000174007.7 | 1.76E-6 | 0 | -1363 | gtex_brain_putamen_basal |
| rs9846528 | 3 | 196440733 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -1569 | gtex_brain_putamen_basal |
| rs9850649 | 3 | 196440808 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -1644 | gtex_brain_putamen_basal |
| rs9863919 | 3 | 196440935 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -1771 | gtex_brain_putamen_basal |
| rs11185453 | 3 | 196441140 | CEP19 | ENSG00000174007.7 | 6.644E-7 | 0 | -1976 | gtex_brain_putamen_basal |
| rs11185454 | 3 | 196441170 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -2006 | gtex_brain_putamen_basal |
| rs73089240 | 3 | 196441583 | CEP19 | ENSG00000174007.7 | 1.853E-6 | 0 | -2419 | gtex_brain_putamen_basal |
| rs1580470 | 3 | 196442132 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -2968 | gtex_brain_putamen_basal |
| rs7627914 | 3 | 196442734 | CEP19 | ENSG00000174007.7 | 1.467E-6 | 0 | -3570 | gtex_brain_putamen_basal |
| rs1906045 | 3 | 196443826 | CEP19 | ENSG00000174007.7 | 1.523E-6 | 0 | -4662 | gtex_brain_putamen_basal |
| rs56196731 | 3 | 196443996 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -4832 | gtex_brain_putamen_basal |
| rs79777668 | 3 | 196444636 | CEP19 | ENSG00000174007.7 | 7.221E-7 | 0 | -5472 | gtex_brain_putamen_basal |
| rs7632005 | 3 | 196444970 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -5806 | gtex_brain_putamen_basal |
| rs7632017 | 3 | 196445009 | CEP19 | ENSG00000174007.7 | 1.535E-6 | 0 | -5845 | gtex_brain_putamen_basal |
| rs9789985 | 3 | 196445436 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -6272 | gtex_brain_putamen_basal |
| rs9790275 | 3 | 196445482 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -6318 | gtex_brain_putamen_basal |
| rs73203735 | 3 | 196446161 | CEP19 | ENSG00000174007.7 | 7.498E-7 | 0 | -6997 | gtex_brain_putamen_basal |
| rs55809933 | 3 | 196447340 | CEP19 | ENSG00000174007.7 | 7.843E-7 | 0 | -8176 | gtex_brain_putamen_basal |
| rs67887445 | 3 | 196447519 | CEP19 | ENSG00000174007.7 | 1.242E-6 | 0 | -8355 | gtex_brain_putamen_basal |
| rs77654748 | 3 | 196447619 | CEP19 | ENSG00000174007.7 | 7.892E-7 | 0 | -8455 | gtex_brain_putamen_basal |
| rs9864896 | 3 | 196448103 | CEP19 | ENSG00000174007.7 | 1.376E-6 | 0 | -8939 | gtex_brain_putamen_basal |
| rs9869881 | 3 | 196448911 | CEP19 | ENSG00000174007.7 | 8.287E-7 | 0 | -9747 | gtex_brain_putamen_basal |
| rs1567766 | 3 | 196450415 | CEP19 | ENSG00000174007.7 | 8.78E-7 | 0 | -11251 | gtex_brain_putamen_basal |
| rs28454528 | 3 | 196451134 | CEP19 | ENSG00000174007.7 | 9.923E-7 | 0 | -11970 | gtex_brain_putamen_basal |
| rs2049232 | 3 | 196452238 | CEP19 | ENSG00000174007.7 | 3.978E-7 | 0 | -13074 | gtex_brain_putamen_basal |
| rs1976847 | 3 | 196453427 | CEP19 | ENSG00000174007.7 | 1.274E-6 | 0 | -14263 | gtex_brain_putamen_basal |
| rs1568603 | 3 | 196453467 | CEP19 | ENSG00000174007.7 | 4.339E-7 | 0 | -14303 | gtex_brain_putamen_basal |
| rs12637375 | 3 | 196453654 | CEP19 | ENSG00000174007.7 | 7.185E-7 | 0 | -14490 | gtex_brain_putamen_basal |
| rs6772328 | 3 | 196457132 | CEP19 | ENSG00000174007.7 | 9.831E-7 | 0 | -17968 | gtex_brain_putamen_basal |
| rs56342540 | 3 | 196458538 | CEP19 | ENSG00000174007.7 | 7.068E-7 | 0 | -19374 | gtex_brain_putamen_basal |
| rs73072745 | 3 | 196459004 | CEP19 | ENSG00000174007.7 | 1.321E-6 | 0 | -19840 | gtex_brain_putamen_basal |
| rs9860612 | 3 | 196459300 | CEP19 | ENSG00000174007.7 | 1.653E-6 | 0 | -20136 | gtex_brain_putamen_basal |
| rs9847505 | 3 | 196459301 | CEP19 | ENSG00000174007.7 | 1.702E-6 | 0 | -20137 | gtex_brain_putamen_basal |
| rs3850647 | 3 | 196459709 | CEP19 | ENSG00000174007.7 | 7.299E-7 | 0 | -20545 | gtex_brain_putamen_basal |
| rs6805472 | 3 | 196461169 | CEP19 | ENSG00000174007.7 | 1.395E-6 | 0 | -22005 | gtex_brain_putamen_basal |
| rs1047113 | 3 | 196461474 | CEP19 | ENSG00000174007.7 | 1.026E-6 | 0 | -22310 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |